Polyphyllin I attenuates cognitive impairments and reduces AD‐like pathology through CIP2A‐PP2A signaling pathway in 3XTg‐AD mice

Polyphyllin I (PPI) is a natural phytochemical drug isolated from plants which can inhibit the proliferation of cancer cells. One of the PPI tumor‐inhibitory effects is through downregulating the expression of Cancerous Inhibitor of PP2A (CIP2A), the latter, is found upregulated in Alzheimer's...

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Veröffentlicht in:	The FASEB journal 2020-12, Vol.34 (12), p.16414-16431
Hauptverfasser:	Zhou, Ying, Yang, Dichen, Chen, Hao, Zheng, Chenfei, Jiang, Huanchang, Liu, Xiaoyuan, Huang, Xingzhou, Ye, Simin, Song, Shuangshuang, Jiang, Nan, Zhao, Zhongyuan, Ma, Shuqing, Ma, Jun, Huang, Kate, Chen, Chaosheng, Fan, Xiaofang, Gong, Yongsheng, Wang, Xiaochuan, Fan, Junming, Liu, Rong, Shentu, Yangping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Animals Autoantigens - metabolism cancerous inhibitor of PP2A (CIP2A) Cell Line Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism cognitive impairments Diosgenin - analogs & derivatives Diosgenin - pharmacology Enzyme Inhibitors - pharmacology HEK293 Cells Humans Male Membrane Proteins - metabolism Mice Mice, Transgenic Neurons - drug effects Neurons - metabolism polyphyllin I (PPI) Protein Phosphatase 2 - metabolism Signal Transduction - drug effects
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