Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways

Pancreatic ductal adenocarcinoma (PDA) is an aggressive type of malignant tumor with a poor prognosis and high mortality. Aberrant activation of hedgehog signaling plays a crucial role in the maintenance and progression of PDA. Here, we report that the dietary bioflavonoid quercetin has therapeutic...

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Veröffentlicht in:	Cell biology and toxicology 2021-06, Vol.37 (3), p.479-496
Hauptverfasser:	Guo, Yangyang, Tong, Yu, Zhu, Hengyue, Xiao, Yanyi, Guo, Hangcheng, Shang, Lumeng, Zheng, Wenjing, Ma, Shumei, Liu, Xiaodong, Bai, Yongheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - pathology Animal models Animals Apoptosis Biochemistry Biomedical and Life Sciences c-Myc protein Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell Biology Cell Line, Tumor Cell proliferation Gene Expression Regulation, Neoplastic - drug effects Hedgehog protein Hedgehog Proteins - genetics Heterografts Humans Inactivation Kinases Life Sciences Mesenchyme Metastases Metastasis Mice Mitochondria Myc protein Nuclear Proteins - genetics Pancreatic cancer Pharmacology/Toxicology Quercetin Quercetin - pharmacology Signal transduction Signal Transduction - drug effects Signaling Smad protein Smad2 protein Smad2 Protein - genetics Smad3 Protein - genetics Transforming Growth Factor beta1 - genetics Transforming growth factor-b1 Tumors Xenografts Xenotransplantation Zinc Finger Protein Gli2 - genetics
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