RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3

DEAD-box (DDX) helicases are critical for recognizing viral nucleic acids to regulate antiviral innate immunity. Although DDX5 has been reported to participate in various virus infection, whether DDX5 regulates innate immune responses and its underlying mechanisms are still unknown. Here, we report...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental cell research 2020-11, Vol.396 (2), p.112332-112332, Article 112332
Hauptverfasser:	Zan, Jie, Xu, Ruixian, Tang, Xialin, Lu, Minyi, Xie, Shanshan, Cai, Jun, Huang, Zhi, Zhang, Jinyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DEAD-Box RNA helicase DEAD-box RNA Helicases - metabolism Female Gene Knockdown Techniques Immunity, Innate Innate immune responses Interferon regulatory factor 3 Interferon Regulatory Factor-3 - metabolism Interferon Type I - metabolism Mice, Inbred C57BL Phosphorylation Protein Binding Protein Phosphatase 2 - metabolism Serine/threonine-protein phosphatase 2A catalytic Subunit beta Type I IFN Up-Regulation - genetics Virus Diseases - metabolism Virus Diseases - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!