Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation

Midkine (MDK) might mediate the proangiogenic effect of intermittent hypoxia (IH) in patients with obstructive sleep apnea (OSA) and cutaneous melanoma (CM). We compare circulating MDK in CM patients with and without OSA, and their relationship with tumor aggressiveness, while exploring in vitro eff...

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Veröffentlicht in:	The FASEB journal 2020-12, Vol.34 (12), p.16179-16190
Hauptverfasser:	Cubillos‐Zapata, Carolina, Martínez‐García, Miguel Ángel, Díaz‐García, Elena, Toledano, Victor, Campos‐Rodríguez, Francisco, Sánchez‐de‐la‐Torre, Manuel, Nagore, Eduardo, Martorell‐Calatayud, Antonio, Hernández Blasco, Luis, Pastor, Esther, Abad‐Capa, Jorge, Montserrat, Josep María, Cabriada‐Nuño, Valentín, Cano‐Pumarega, Irene, Corral‐Peñafiel, Jaime, Arias, Eva, Mediano, Olga, Somoza‐González, María, Dalmau‐Arias, Joan, Almendros, Isaac, Farré, Ramón, López‐Collazo, Eduardo, Gozal, David, García‐Río, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged aggressiveness Cell Line, Tumor Cell Proliferation - physiology Cells, Cultured Cross-Sectional Studies Female Humans Hypoxia - metabolism Hypoxia - pathology intermittent hypoxia lymphangiogenesis Male melanoma Melanoma - metabolism Melanoma - pathology Melanoma, Cutaneous Malignant Middle Aged Midkine - metabolism Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Skin Neoplasms - metabolism Skin Neoplasms - pathology sleep apnea Sleep Apnea, Obstructive - metabolism Sleep Apnea, Obstructive - pathology Vascular Endothelial Growth Factor A - metabolism
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