MCU-dependent negative sorting of miR-4488 to extracellular vesicles enhances angiogenesis and promotes breast cancer metastatic colonization

Based on Stephen Paget’s well-established theory, both cell-autonomous and non-cell-autonomous mechanisms are crucial for metastasis. Although the mitochondrial calcium uniporter (MCU) has been suggested to be involved in breast cancer (BC) progression via cell-autonomous mechanisms, whether it assi...

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Veröffentlicht in:	Oncogene 2020-11, Vol.39 (46), p.6975-6989
Hauptverfasser:	Zheng, Xianchong, Lu, Sitong, He, Zhanxin, Huang, Hehai, Yao, Zhuocheng, Miao, Yutian, Cai, Chunqing, Zou, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/2328 631/67/322 82/80 Angiogenesis Animals Apoptosis Breast cancer Calcium (mitochondrial) Calcium Channels - metabolism Care and treatment Cell Biology Cell Line, Tumor Cell Movement Chemokine CX3CL1 - genetics Chemokine CX3CL1 - metabolism Circulating MicroRNA - metabolism Colonization Complications and side effects Disease-Free Survival Endothelial cells Extracellular vesicles Extracellular Vesicles - metabolism Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Human Genetics Human Umbilical Vein Endothelial Cells Humans Internal Medicine Kaplan-Meier Estimate Medicine Medicine & Public Health Metastases Metastasis Mice MicroRNA MicroRNAs - metabolism Mitochondria Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neovascularization Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Oncology Prognosis Risk factors Triple Negative Breast Neoplasms - blood Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology
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