TIM2 modulates retinal iron levels and is involved in blood-retinal barrier breakdown

Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has also been proposed as an iron-tran...

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Veröffentlicht in:	Experimental eye research 2021-01, Vol.202, p.108292-108292, Article 108292
Hauptverfasser:	Valença, Andreia, Mendes-Jorge, Luísa, Bonet, Aina, Catita, Joana, Ramos, David, Jose-Cunilleras, Eduard, Garcia, Miguel, Carretero, Ana, Nacher, Victor, Navarro, Marc, Ruberte, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Blood-Retinal Barrier - physiology Blotting, Western BRB breakdown Ependymoglial Cells - metabolism Ferritins - metabolism Homeostasis - physiology Immunohistochemistry Iron overload Membrane Proteins - physiology Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron, Transmission Ophthalmoscopy Oxidative Stress Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Retinal edema Scara5 Scavenger Receptors, Class A - metabolism Spectrometry, X-Ray Emission Tandem Mass Spectrometry TIM2 Vascular Endothelial Growth Factor A - metabolism VEGF overexpression
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