The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells

[Display omitted] Alternative splicing of the androgen receptor (AR) is frequently observed in castration resistant prostate cancer (CRPC). One AR isoform, the AR-V7 splice variant, is a constitutively active transcription factor which lacks a ligand binding domain and is therefore undruggable. AR-V...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2020-10, Vol.28 (20), p.115712-115712, Article 115712
Hauptverfasser:	Melnyk, James E., Steri, Veronica, Nguyen, Hao G., Hann, Byron, Feng, Felix Y., Shokat, Kevan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Androgen receptor AR-V7 Indisulam Prostate cancer RBM39
Online-Zugang:	Volltext
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