Progress in the Development of Small Molecular Inhibitors of Focal Adhesion Kinase (FAK)

Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an essential role in cancer cell adhesion, survival, proliferation, and migration through both its enzymatic activities and scaffolding functions. Overexpression of FAK has been found in many human cancer cells fro...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-12, Vol.63 (23), p.14382-14403
Hauptverfasser:	Lu, Yang, Sun, Haiying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - drug effects Enzyme Activation Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - chemistry Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Phosphorylation Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship
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