Delayed notochordal cell disappearance through integrin α5β1 mechanotransduction during ex‐vivo dynamic loading‐induced intervertebral disc degeneration

The loss of nucleus pulposus (NP) notochordal cells is one of the key initial hallmarks of age‐related intervertebral disc degeneration. Although the transmembrane mechanoreceptor integrin α5β1 is important in the process of disc degeneration, the relationship between integrin α5β1 and notochordal c...

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Veröffentlicht in:	Journal of orthopaedic research 2021-09, Vol.39 (9), p.1933-1944
Hauptverfasser:	Kanda, Yutaro, Yurube, Takashi, Morita, Yusuke, Takeoka, Yoshiki, Kurakawa, Takuto, Tsujimoto, Ryu, Miyazaki, Kunihiko, Kakiuchi, Yuji, Miyazaki, Shingo, Zhang, Zhongying, Takada, Toru, Hoshino, Yuichi, Masuda, Koichi, Kuroda, Ryosuke, Kakutani, Kenichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptotic cell death Biomarkers - metabolism dynamic loading Integrin alpha5beta1 - metabolism integrin mechanotransduction Intervertebral Disc - pathology intervertebral disc degeneration Intervertebral Disc Degeneration - pathology Mechanotransduction, Cellular Notochord notochordal cell phenotype Rats Reproducibility of Results
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