Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent
Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on‐demand antibacterial effects. In this study, a Staphylococcus aureus (S. aureus) se...
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| Veröffentlicht in: | Macromolecular bioscience 2021-01, Vol.21 (1), p.e2000194-n/a |
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| container_title | Macromolecular bioscience |
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| creator | Zhang, Yunfei Hu, Kuan Xing, Xuan Zhang, Jingshuang Zhang, Ming‐Rong Ma, Xiaohui Shi, Rui Zhang, Liqun |
| description | Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on‐demand antibacterial effects. In this study, a Staphylococcus aureus (S. aureus) sensitive peptide sequence is designed, and an antibiotic is then conjugated with this tailor‐made peptide. The antibiotic‐peptide conjugate is then linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by S. aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.
Tailor‐made peptide–vancomycin conjugate is linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by Staphylococcus aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs. |
| doi_str_mv | 10.1002/mabi.202000194 |
| format | Article |
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Tailor‐made peptide–vancomycin conjugate is linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by Staphylococcus aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.202000194</identifier><identifier>PMID: 33052007</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Antibacterial activity ; antibacterial coating ; Antibacterial materials ; antibiotic conjugated peptide ; Antibiotics ; Coating ; Coatings ; Infections ; Penicillin ; Peptides ; stimuli‐driven drug release ; Titanium</subject><ispartof>Macromolecular bioscience, 2021-01, Vol.21 (1), p.e2000194-n/a</ispartof><rights>2020 Wiley‐VCH GmbH</rights><rights>2020 Wiley-VCH GmbH.</rights><rights>2021 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4764-5bed47c48dbec015bf9bf61efde59941ce271f4f4553117280572f293a059093</citedby><cites>FETCH-LOGICAL-c4764-5bed47c48dbec015bf9bf61efde59941ce271f4f4553117280572f293a059093</cites><orcidid>0000-0002-2103-6294</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmabi.202000194$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.202000194$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33052007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yunfei</creatorcontrib><creatorcontrib>Hu, Kuan</creatorcontrib><creatorcontrib>Xing, Xuan</creatorcontrib><creatorcontrib>Zhang, Jingshuang</creatorcontrib><creatorcontrib>Zhang, Ming‐Rong</creatorcontrib><creatorcontrib>Ma, Xiaohui</creatorcontrib><creatorcontrib>Shi, Rui</creatorcontrib><creatorcontrib>Zhang, Liqun</creatorcontrib><title>Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent</title><title>Macromolecular bioscience</title><addtitle>Macromol Biosci</addtitle><description>Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on‐demand antibacterial effects. In this study, a Staphylococcus aureus (S. aureus) sensitive peptide sequence is designed, and an antibiotic is then conjugated with this tailor‐made peptide. The antibiotic‐peptide conjugate is then linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by S. aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.
Tailor‐made peptide–vancomycin conjugate is linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by Staphylococcus aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.</description><subject>Antibacterial activity</subject><subject>antibacterial coating</subject><subject>Antibacterial materials</subject><subject>antibiotic conjugated peptide</subject><subject>Antibiotics</subject><subject>Coating</subject><subject>Coatings</subject><subject>Infections</subject><subject>Penicillin</subject><subject>Peptides</subject><subject>stimuli‐driven drug release</subject><subject>Titanium</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkcFqGzEURUVpqN0k2yzDQDbd2JE0kjVaOiZpDC4JrfeDRvNkZGakyUiTkF0_Id_YL6mMHQe6KQiekM69PO5F6ILgKcGYXreqslOKKcaYSPYJjcmMzCacSP75eC_ECH0NYZsQUUj6BY3yHPMkEWPU_2pVH7O1jcrZoc0WXkXrNmm2nQ9QZ95kcxdtZX20Oj277bBRMX08QhdtDSFT6bhs6QzoaL378_vtJ4TOu2CfYa9VOkJvVZPNN-DiGToxqglwfpinaH13u17cT1YP35eL-WqimZixCa-gZkKzoq5AY8IrIyszI2Bq4FIyooEKYphhnOeECFpgLqihMleYSyzzU_Rtb9v1_mmAEMvWBg1Noxz4IZSUcUJyWkiS0Kt_0K0fepeWS5QQcpdtnqjpntK9D6EHU3a9Tem9lgSXuzLKXRnlsYwkuDzYDlUL9RF_Tz8Bcg-82AZe_2NX_pjfLD_M_wLWQpbn</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Zhang, Yunfei</creator><creator>Hu, Kuan</creator><creator>Xing, Xuan</creator><creator>Zhang, Jingshuang</creator><creator>Zhang, Ming‐Rong</creator><creator>Ma, Xiaohui</creator><creator>Shi, Rui</creator><creator>Zhang, Liqun</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2103-6294</orcidid></search><sort><creationdate>202101</creationdate><title>Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent</title><author>Zhang, Yunfei ; Hu, Kuan ; Xing, Xuan ; Zhang, Jingshuang ; Zhang, Ming‐Rong ; Ma, Xiaohui ; Shi, Rui ; Zhang, Liqun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4764-5bed47c48dbec015bf9bf61efde59941ce271f4f4553117280572f293a059093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibacterial activity</topic><topic>antibacterial coating</topic><topic>Antibacterial materials</topic><topic>antibiotic conjugated peptide</topic><topic>Antibiotics</topic><topic>Coating</topic><topic>Coatings</topic><topic>Infections</topic><topic>Penicillin</topic><topic>Peptides</topic><topic>stimuli‐driven drug release</topic><topic>Titanium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yunfei</creatorcontrib><creatorcontrib>Hu, Kuan</creatorcontrib><creatorcontrib>Xing, Xuan</creatorcontrib><creatorcontrib>Zhang, Jingshuang</creatorcontrib><creatorcontrib>Zhang, Ming‐Rong</creatorcontrib><creatorcontrib>Ma, Xiaohui</creatorcontrib><creatorcontrib>Shi, Rui</creatorcontrib><creatorcontrib>Zhang, Liqun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yunfei</au><au>Hu, Kuan</au><au>Xing, Xuan</au><au>Zhang, Jingshuang</au><au>Zhang, Ming‐Rong</au><au>Ma, Xiaohui</au><au>Shi, Rui</au><au>Zhang, Liqun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol Biosci</addtitle><date>2021-01</date><risdate>2021</risdate><volume>21</volume><issue>1</issue><spage>e2000194</spage><epage>n/a</epage><pages>e2000194-n/a</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on‐demand antibacterial effects. In this study, a Staphylococcus aureus (S. aureus) sensitive peptide sequence is designed, and an antibiotic is then conjugated with this tailor‐made peptide. The antibiotic‐peptide conjugate is then linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by S. aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.
Tailor‐made peptide–vancomycin conjugate is linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by Staphylococcus aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33052007</pmid><doi>10.1002/mabi.202000194</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2103-6294</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | Antibacterial activity antibacterial coating Antibacterial materials antibiotic conjugated peptide Antibiotics Coating Coatings Infections Penicillin Peptides stimuli‐driven drug release Titanium |
| title | Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent |
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