Sigma‐1 receptor antagonist (BD‐1063) potentiates the antinociceptive effect of quercetin in neuropathic pain induced by chronic constriction injury

Neuropathic pain is characterized by the presence of hyperalgesia and allodynia. Pharmacological treatments include the use of antiepileptics such as pregabalin or gabapentin, as well as antidepressants; however, given the role of the sigma‐1 receptor in the generation and maintenance of pain, it ha...

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Veröffentlicht in:	Drug development research 2021-04, Vol.82 (2), p.267-277
Hauptverfasser:	Espinosa‐Juárez, Josué Vidal, Jaramillo‐Morales, Osmar Antonio, Déciga‐Campos, Myrna, Moreno‐Rocha, Luis Alfonso, López‐Muñoz, Francisco Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - administration & dosage Animals Antidepressants Antioxidants - administration & dosage BD‐1063 Constriction Constrictions Dose-Response Relationship, Drug Drug Synergism Drug therapy Flavonoids Gabapentin Male Neuralgia Neuralgia - drug therapy Neuralgia - metabolism neuropathic pain Pain Pain Measurement - drug effects Pain Measurement - methods Pain perception Piperazines - administration & dosage Quercetin Quercetin - administration & dosage Rats Rats, Wistar Receptors Receptors, sigma - antagonists & inhibitors Receptors, sigma - metabolism Sciatic nerve Sigma-1 Receptor synergism Synergistic effect
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