Combination of metformin and RG7388 enhances inhibition of growth and induction of apoptosis of ovarian cancer cells through the PI3K/AKT/mTOR pathway

Ovarian cancer is a gynecological cancer that has the highest mortality rate and is often resistant to conventional treatments. Therefore, development of new therapies is essential. Metformin (MET), which is the priority drug for treatment of type 2 diabetes, has received increasing attention becaus...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-12, Vol.533 (4), p.665-671
Hauptverfasser:	Cui, Yingying, Zhou, Jing, Rong, Fengnian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics Female Humans MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics metformin Metformin - pharmacology Mice, Nude Ovarian cancer therapy Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology para-Aminobenzoates - pharmacology Phosphatidylinositol 3-Kinase - metabolism Proto-Oncogene Proteins c-akt - metabolism Pyrrolidines - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism RG7388 TOR Serine-Threonine Kinases - metabolism Xenograft Model Antitumor Assays
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