A Randomized Trial Comparing Brief Advice and Motivational Interviewing for Persons with HIV–HCV Co-infection Who Drink Alcohol
Alcohol use contributes to the progression of liver disease in HIV–HCV co-infected persons, but alcohol interventions have never addressed low levels of alcohol use in this population. We enrolled 110 persons consuming at least 4 alcoholic drinks weekly in a clinical trial comparing two active 18-mo...
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| Veröffentlicht in: | AIDS and behavior 2021-04, Vol.25 (4), p.1013-1025 |
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| creator | Stein, Michael D. Herman, Debra S. Kim, H. Nina Howell, Abigail Lambert, Audrey Madden, Stephanie Moitra, Ethan Blevins, Claire E. Anderson, Bradley J. Taylor, Lynn E. Pinkston, Megan M. |
| description | Alcohol use contributes to the progression of liver disease in HIV–HCV co-infected persons, but alcohol interventions have never addressed low levels of alcohol use in this population. We enrolled 110 persons consuming at least 4 alcoholic drinks weekly in a clinical trial comparing two active 18-month long interventions, delivered every 3 months by phone, brief advice about drinking versus a motivational intervention. Final assessment was at 24 months. MI had larger reductions in alcohol use days than the BA arm at all follow-up assessments. The treatment by time effect was not significant for days of drinking (p = 0.470), mean drinks per day (p = 0.155), or for the continuous FIB-4 index (p = 0.175). Drinking declined in both conditions from baseline, but given the small sample, we do not have sufficient data to make any conclusion that one treatment is superior to the other.
Trial Registry
Trial registered at clinicaltrials.gov; Clinical Trial NCT02316184. |
| doi_str_mv | 10.1007/s10461-020-03062-2 |
| format | Article |
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Trial Registry
Trial registered at clinicaltrials.gov; Clinical Trial NCT02316184.</description><identifier>ISSN: 1090-7165</identifier><identifier>EISSN: 1573-3254</identifier><identifier>DOI: 10.1007/s10461-020-03062-2</identifier><identifier>PMID: 33047258</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alcohol Drinking ; Alcohol use ; Alcoholic beverages ; Clinical trials ; Coinfection ; Crisis Intervention ; Drinking ; Drinking behavior ; Health Psychology ; Health services ; Hepatitis C - complications ; Hepatitis C - prevention & control ; HIV ; HIV Infections - complications ; HIV Infections - prevention & control ; Human immunodeficiency virus ; Humans ; Infectious Diseases ; Interviews ; Liver diseases ; Medicine ; Medicine & Public Health ; Motivation ; Motivational Interviewing ; NCT ; NCT02316184 ; Original Paper ; Public Health</subject><ispartof>AIDS and behavior, 2021-04, Vol.25 (4), p.1013-1025</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-d7c9fbc0cd7efe51f539867224ac87247527e80f69ad9612c690f31f34714b653</citedby><cites>FETCH-LOGICAL-c375t-d7c9fbc0cd7efe51f539867224ac87247527e80f69ad9612c690f31f34714b653</cites><orcidid>0000-0002-2466-5192</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10461-020-03062-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10461-020-03062-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27344,27924,27925,33774,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33047258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stein, Michael D.</creatorcontrib><creatorcontrib>Herman, Debra S.</creatorcontrib><creatorcontrib>Kim, H. Nina</creatorcontrib><creatorcontrib>Howell, Abigail</creatorcontrib><creatorcontrib>Lambert, Audrey</creatorcontrib><creatorcontrib>Madden, Stephanie</creatorcontrib><creatorcontrib>Moitra, Ethan</creatorcontrib><creatorcontrib>Blevins, Claire E.</creatorcontrib><creatorcontrib>Anderson, Bradley J.</creatorcontrib><creatorcontrib>Taylor, Lynn E.</creatorcontrib><creatorcontrib>Pinkston, Megan M.</creatorcontrib><title>A Randomized Trial Comparing Brief Advice and Motivational Interviewing for Persons with HIV–HCV Co-infection Who Drink Alcohol</title><title>AIDS and behavior</title><addtitle>AIDS Behav</addtitle><addtitle>AIDS Behav</addtitle><description>Alcohol use contributes to the progression of liver disease in HIV–HCV co-infected persons, but alcohol interventions have never addressed low levels of alcohol use in this population. We enrolled 110 persons consuming at least 4 alcoholic drinks weekly in a clinical trial comparing two active 18-month long interventions, delivered every 3 months by phone, brief advice about drinking versus a motivational intervention. Final assessment was at 24 months. MI had larger reductions in alcohol use days than the BA arm at all follow-up assessments. The treatment by time effect was not significant for days of drinking (p = 0.470), mean drinks per day (p = 0.155), or for the continuous FIB-4 index (p = 0.175). Drinking declined in both conditions from baseline, but given the small sample, we do not have sufficient data to make any conclusion that one treatment is superior to the other.
Trial Registry
Trial registered at clinicaltrials.gov; Clinical Trial NCT02316184.</description><subject>Alcohol Drinking</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Clinical trials</subject><subject>Coinfection</subject><subject>Crisis Intervention</subject><subject>Drinking</subject><subject>Drinking behavior</subject><subject>Health Psychology</subject><subject>Health services</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - prevention & control</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - prevention & control</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Interviews</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Motivation</subject><subject>Motivational Interviewing</subject><subject>NCT</subject><subject>NCT02316184</subject><subject>Original Paper</subject><subject>Public Health</subject><issn>1090-7165</issn><issn>1573-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>BHHNA</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc-OUyEYR4kZ44yjL-DCkMzGDfoBFyjLWv-0yRiNGccloVywjPdeKty2mVnpM_iGPonUjpq4cAWL8zuEHIQeUXhKAdSzQqGRlAADAhwkI-wOOqFCccKZaI7qHTQQRaU4RvdLuQIALZW-h445h0YxMTlB36b4vR3a1Mcb3-KLHG2HZ6lf2xyHT_h5jj7gabuNzuOK4TdpjFs7xjRUbjGMPm-j3-3RkDJ-53NJQ8G7OK7wfHH54-v3-eyy-kgcgnf7Gf64SvhFlX_G086lVeoeoLvBdsU_vD1P0YdXLy9mc3L-9vViNj0njisxklY5HZYOXKt88IIGwfVEKsYa6yaKNUow5ScQpLatlpQ5qSFwGnijaLOUgp-iJwfvOqcvG19G08fifNfZwadNMawRIAUozit69g96lTa5frlSApiQSmhZKXagXE6lZB_MOsfe5mtDwewDmUMgUwOZX4EMq6PHt-rNsvftn8nvIhXgB6Cs9wl8_vv2f7Q_AffGmzA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Stein, Michael D.</creator><creator>Herman, Debra S.</creator><creator>Kim, H. 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Nina</au><au>Howell, Abigail</au><au>Lambert, Audrey</au><au>Madden, Stephanie</au><au>Moitra, Ethan</au><au>Blevins, Claire E.</au><au>Anderson, Bradley J.</au><au>Taylor, Lynn E.</au><au>Pinkston, Megan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized Trial Comparing Brief Advice and Motivational Interviewing for Persons with HIV–HCV Co-infection Who Drink Alcohol</atitle><jtitle>AIDS and behavior</jtitle><stitle>AIDS Behav</stitle><addtitle>AIDS Behav</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>25</volume><issue>4</issue><spage>1013</spage><epage>1025</epage><pages>1013-1025</pages><issn>1090-7165</issn><eissn>1573-3254</eissn><abstract>Alcohol use contributes to the progression of liver disease in HIV–HCV co-infected persons, but alcohol interventions have never addressed low levels of alcohol use in this population. We enrolled 110 persons consuming at least 4 alcoholic drinks weekly in a clinical trial comparing two active 18-month long interventions, delivered every 3 months by phone, brief advice about drinking versus a motivational intervention. Final assessment was at 24 months. MI had larger reductions in alcohol use days than the BA arm at all follow-up assessments. The treatment by time effect was not significant for days of drinking (p = 0.470), mean drinks per day (p = 0.155), or for the continuous FIB-4 index (p = 0.175). Drinking declined in both conditions from baseline, but given the small sample, we do not have sufficient data to make any conclusion that one treatment is superior to the other.
Trial Registry
Trial registered at clinicaltrials.gov; Clinical Trial NCT02316184.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33047258</pmid><doi>10.1007/s10461-020-03062-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2466-5192</orcidid></addata></record> |
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| subjects | Alcohol Drinking Alcohol use Alcoholic beverages Clinical trials Coinfection Crisis Intervention Drinking Drinking behavior Health Psychology Health services Hepatitis C - complications Hepatitis C - prevention & control HIV HIV Infections - complications HIV Infections - prevention & control Human immunodeficiency virus Humans Infectious Diseases Interviews Liver diseases Medicine Medicine & Public Health Motivation Motivational Interviewing NCT NCT02316184 Original Paper Public Health |
| title | A Randomized Trial Comparing Brief Advice and Motivational Interviewing for Persons with HIV–HCV Co-infection Who Drink Alcohol |
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