Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure
Background Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS). Methods All patients undergoing OHT from 2000 to 2018 at our center were reviewed. P...
Gespeichert in:
| Veröffentlicht in: | Journal of cardiac surgery 2020-12, Vol.35 (12), p.3381-3386 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3386 |
|---|---|
| container_issue | 12 |
| container_start_page | 3381 |
| container_title | Journal of cardiac surgery |
| container_volume | 35 |
| creator | D'Angelo, Alex M. Naka, Yoshifumi Sanchez, Joseph Kaku, Yuji Witer, Lucas Fried, Justin Masoumi, Amirali Farr, Maryjane A. Sayer, Gabriel Uriel, Nir Takeda, Koji |
| description | Background
Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS).
Methods
All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re‐admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated.
Results
Twenty‐six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%). |
| doi_str_mv | 10.1111/jocs.15089 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2450650556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2450650556</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3659-d0e40d41115f0f509fe2559cd9652495c0c81d7fc82ab7640643c8ebf983ba2c3</originalsourceid><addsrcrecordid>eNp9kE1PwzAMhiMEYmNw4QegHBFSwWmSrj2iiU9N2gE4V6mbbB3pUpJW0_49HR0c8cWW_PiR_BJyyeCW9XW3dhhumYQ0OyJjJgVEKcvYMRlDmiYRCAEjchbCGiCOBYdTMuIcxJRLPia46Fp0tQ7UGVprXKlNhcrS0DWN8y01zlNUvqzcUvcbGlYOP6kKwWGlWl3SbdWuqO3HAVNIlbVu6ZXpj1VlO6_PyYlRNuiLQ5-Qj8eH99lzNF88vczu5xHyRGZRCVpAKfqPpAEjITM6ljLDMktkLDKJgCkrpwbTWBXTREAiOKa6MFnKCxUjn5Drwdt499Xp0OZ1FVBbqzbadSGPhYREgpRJj94MKHoXgtcmb3xVK7_LGeT7UPN9qPlPqD18dfB2Ra3LP_Q3xR5gA7CtrN79o8pfF7O3QfoNMf-C8w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2450650556</pqid></control><display><type>article</type><title>Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>D'Angelo, Alex M. ; Naka, Yoshifumi ; Sanchez, Joseph ; Kaku, Yuji ; Witer, Lucas ; Fried, Justin ; Masoumi, Amirali ; Farr, Maryjane A. ; Sayer, Gabriel ; Uriel, Nir ; Takeda, Koji</creator><creatorcontrib>D'Angelo, Alex M. ; Naka, Yoshifumi ; Sanchez, Joseph ; Kaku, Yuji ; Witer, Lucas ; Fried, Justin ; Masoumi, Amirali ; Farr, Maryjane A. ; Sayer, Gabriel ; Uriel, Nir ; Takeda, Koji</creatorcontrib><description>Background
Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS).
Methods
All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re‐admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated.
Results
Twenty‐six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).</description><identifier>ISSN: 0886-0440</identifier><identifier>EISSN: 1540-8191</identifier><identifier>DOI: 10.1111/jocs.15089</identifier><identifier>PMID: 33047353</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Allografts ; Female ; Heart Failure - therapy ; Heart Transplantation ; Heart-Assist Devices ; Humans ; late allograft failure ; Male ; mechanical circulatory support ; Retrospective Studies ; Shock, Cardiogenic - etiology ; Shock, Cardiogenic - therapy</subject><ispartof>Journal of cardiac surgery, 2020-12, Vol.35 (12), p.3381-3386</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3659-d0e40d41115f0f509fe2559cd9652495c0c81d7fc82ab7640643c8ebf983ba2c3</citedby><cites>FETCH-LOGICAL-c3659-d0e40d41115f0f509fe2559cd9652495c0c81d7fc82ab7640643c8ebf983ba2c3</cites><orcidid>0000-0002-2309-1799</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocs.15089$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocs.15089$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33047353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'Angelo, Alex M.</creatorcontrib><creatorcontrib>Naka, Yoshifumi</creatorcontrib><creatorcontrib>Sanchez, Joseph</creatorcontrib><creatorcontrib>Kaku, Yuji</creatorcontrib><creatorcontrib>Witer, Lucas</creatorcontrib><creatorcontrib>Fried, Justin</creatorcontrib><creatorcontrib>Masoumi, Amirali</creatorcontrib><creatorcontrib>Farr, Maryjane A.</creatorcontrib><creatorcontrib>Sayer, Gabriel</creatorcontrib><creatorcontrib>Uriel, Nir</creatorcontrib><creatorcontrib>Takeda, Koji</creatorcontrib><title>Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure</title><title>Journal of cardiac surgery</title><addtitle>J Card Surg</addtitle><description>Background
Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS).
Methods
All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re‐admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated.
Results
Twenty‐six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).</description><subject>Adult</subject><subject>Allografts</subject><subject>Female</subject><subject>Heart Failure - therapy</subject><subject>Heart Transplantation</subject><subject>Heart-Assist Devices</subject><subject>Humans</subject><subject>late allograft failure</subject><subject>Male</subject><subject>mechanical circulatory support</subject><subject>Retrospective Studies</subject><subject>Shock, Cardiogenic - etiology</subject><subject>Shock, Cardiogenic - therapy</subject><issn>0886-0440</issn><issn>1540-8191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEYmNw4QegHBFSwWmSrj2iiU9N2gE4V6mbbB3pUpJW0_49HR0c8cWW_PiR_BJyyeCW9XW3dhhumYQ0OyJjJgVEKcvYMRlDmiYRCAEjchbCGiCOBYdTMuIcxJRLPia46Fp0tQ7UGVprXKlNhcrS0DWN8y01zlNUvqzcUvcbGlYOP6kKwWGlWl3SbdWuqO3HAVNIlbVu6ZXpj1VlO6_PyYlRNuiLQ5-Qj8eH99lzNF88vczu5xHyRGZRCVpAKfqPpAEjITM6ljLDMktkLDKJgCkrpwbTWBXTREAiOKa6MFnKCxUjn5Drwdt499Xp0OZ1FVBbqzbadSGPhYREgpRJj94MKHoXgtcmb3xVK7_LGeT7UPN9qPlPqD18dfB2Ra3LP_Q3xR5gA7CtrN79o8pfF7O3QfoNMf-C8w</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>D'Angelo, Alex M.</creator><creator>Naka, Yoshifumi</creator><creator>Sanchez, Joseph</creator><creator>Kaku, Yuji</creator><creator>Witer, Lucas</creator><creator>Fried, Justin</creator><creator>Masoumi, Amirali</creator><creator>Farr, Maryjane A.</creator><creator>Sayer, Gabriel</creator><creator>Uriel, Nir</creator><creator>Takeda, Koji</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2309-1799</orcidid></search><sort><creationdate>202012</creationdate><title>Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure</title><author>D'Angelo, Alex M. ; Naka, Yoshifumi ; Sanchez, Joseph ; Kaku, Yuji ; Witer, Lucas ; Fried, Justin ; Masoumi, Amirali ; Farr, Maryjane A. ; Sayer, Gabriel ; Uriel, Nir ; Takeda, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3659-d0e40d41115f0f509fe2559cd9652495c0c81d7fc82ab7640643c8ebf983ba2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Allografts</topic><topic>Female</topic><topic>Heart Failure - therapy</topic><topic>Heart Transplantation</topic><topic>Heart-Assist Devices</topic><topic>Humans</topic><topic>late allograft failure</topic><topic>Male</topic><topic>mechanical circulatory support</topic><topic>Retrospective Studies</topic><topic>Shock, Cardiogenic - etiology</topic><topic>Shock, Cardiogenic - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'Angelo, Alex M.</creatorcontrib><creatorcontrib>Naka, Yoshifumi</creatorcontrib><creatorcontrib>Sanchez, Joseph</creatorcontrib><creatorcontrib>Kaku, Yuji</creatorcontrib><creatorcontrib>Witer, Lucas</creatorcontrib><creatorcontrib>Fried, Justin</creatorcontrib><creatorcontrib>Masoumi, Amirali</creatorcontrib><creatorcontrib>Farr, Maryjane A.</creatorcontrib><creatorcontrib>Sayer, Gabriel</creatorcontrib><creatorcontrib>Uriel, Nir</creatorcontrib><creatorcontrib>Takeda, Koji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiac surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'Angelo, Alex M.</au><au>Naka, Yoshifumi</au><au>Sanchez, Joseph</au><au>Kaku, Yuji</au><au>Witer, Lucas</au><au>Fried, Justin</au><au>Masoumi, Amirali</au><au>Farr, Maryjane A.</au><au>Sayer, Gabriel</au><au>Uriel, Nir</au><au>Takeda, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure</atitle><jtitle>Journal of cardiac surgery</jtitle><addtitle>J Card Surg</addtitle><date>2020-12</date><risdate>2020</risdate><volume>35</volume><issue>12</issue><spage>3381</spage><epage>3386</epage><pages>3381-3386</pages><issn>0886-0440</issn><eissn>1540-8191</eissn><abstract>Background
Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS).
Methods
All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re‐admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated.
Results
Twenty‐six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).</abstract><cop>United States</cop><pmid>33047353</pmid><doi>10.1111/jocs.15089</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2309-1799</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0886-0440 |
| ispartof | Journal of cardiac surgery, 2020-12, Vol.35 (12), p.3381-3386 |
| issn | 0886-0440 1540-8191 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2450650556 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Allografts Female Heart Failure - therapy Heart Transplantation Heart-Assist Devices Humans late allograft failure Male mechanical circulatory support Retrospective Studies Shock, Cardiogenic - etiology Shock, Cardiogenic - therapy |
| title | Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T16%3A51%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Outcomes%20of%20mechanical%20support%20for%20cardiogenic%20shock%20associated%20with%20late%20cardiac%20allograft%20failure&rft.jtitle=Journal%20of%20cardiac%20surgery&rft.au=D'Angelo,%20Alex%20M.&rft.date=2020-12&rft.volume=35&rft.issue=12&rft.spage=3381&rft.epage=3386&rft.pages=3381-3386&rft.issn=0886-0440&rft.eissn=1540-8191&rft_id=info:doi/10.1111/jocs.15089&rft_dat=%3Cproquest_cross%3E2450650556%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2450650556&rft_id=info:pmid/33047353&rfr_iscdi=true |