Novel idebenone analogs block Shc’s access to insulin receptor to improve insulin sensitivity

[Display omitted] •Idebenone drug engagement of p52Shc protein regulates insulin sensitivity.•Analogs of idebenone engage p52Shc and insulin-sensitizer differentially.•One analog is a more potent insulin sensitizer than idebenone itself.•Idebenone metabolites engage p52Shc and insulin sensitize. The...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2020-12, Vol.132, p.110823-110823, Article 110823
Hauptverfasser:	Hui, ChunKiu, Tomilov, Alexey, Garcia, Chase, Jiang, XiaoSong, Fash, David M., Khdour, Omar M., Rosso, Cristian, Filippini, Giacomo, Prato, Maurizio, Graham, James, Hecht, Sidney, Havel, Peter, Cortopassi, Gino
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Drug discovery Insulin - metabolism Insulin Resistance Mice Mice, Inbred C57BL Novel insulin sensitizing agents Rats Rats, Sprague-Dawley Receptor, Insulin - metabolism Shc blockers Small molecule therapeutics Src Homology 2 Domain-Containing, Transforming Protein 1 - genetics Structure-Activity Relationship Type 2 Diabetes Ubiquinone - analogs & derivatives Ubiquinone - chemistry Ubiquinone - pharmacology
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