A Key Glycine in Bacterial Steroid-Degrading Acyl-CoA Dehydrogenases Allows Flavin-Ring Repositioning and Modulates Substrate Side Chain Specificity

A wide variety of steroid metabolites synthesized by eukaryotes are all ultimately catabolized by bacteria; while generally saprophytic, pathogenic Mycobacteria have repurposed these pathways to utilize host intracellular cholesterol pools. Steroid degradation is complex, but a recurring theme is th...

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Veröffentlicht in:	Biochemistry (Easton) 2020-10, Vol.59 (42), p.4081-4092
Hauptverfasser:	Stirling, Alexander J, Gilbert, Stephanie E, Conner, Megan, Mallette, Evan, Kimber, Matthew S, Seah, Stephen Y. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenase - chemistry Acyl-CoA Dehydrogenase - metabolism Catalytic Domain Glycine - metabolism Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - metabolism Steroids - metabolism Substrate Specificity
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