Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition
Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyviny...
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| Veröffentlicht in: | Nanotechnology 2021-01, Vol.32 (1), p.015101-015101 |
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| container_title | Nanotechnology |
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| creator | Li, Baoe Xia, Xiaomei Chen, Jiatian Xia, Dan Xu, Ruodan Zou, Xianrui Wang, Hongshui Liang, Chunyong |
| description | Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has been fabricated into a composite nanofibrous membrane (PVA/PVP-PLNPs) for use as a drug carrier using the electrospinning technique. The fabricated PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability and biocompatibility. In vitro experiments showed that combining lignin nanoparticles by electrospinning not only improved the drug release profile, but also enhanced the hydrophilicity of nanofibrous membranes which was beneficial to cell adhesion and proliferation. Cellular experiments demonstrated that PVA/PVP-2%PLNPs membrane showed good cell inhibition ability, and the cell survival rate was only 21% at day 7. It indicates that the as-prepared PVA/PVP-PLNPs composite nanofibers are promising candidates for local anticancer therapy. |
| doi_str_mv | 10.1088/1361-6528/abb55a |
| format | Article |
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Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has been fabricated into a composite nanofibrous membrane (PVA/PVP-PLNPs) for use as a drug carrier using the electrospinning technique. The fabricated PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability and biocompatibility. In vitro experiments showed that combining lignin nanoparticles by electrospinning not only improved the drug release profile, but also enhanced the hydrophilicity of nanofibrous membranes which was beneficial to cell adhesion and proliferation. Cellular experiments demonstrated that PVA/PVP-2%PLNPs membrane showed good cell inhibition ability, and the cell survival rate was only 21% at day 7. It indicates that the as-prepared PVA/PVP-PLNPs composite nanofibers are promising candidates for local anticancer therapy.</description><identifier>ISSN: 0957-4484</identifier><identifier>EISSN: 1361-6528</identifier><identifier>DOI: 10.1088/1361-6528/abb55a</identifier><identifier>PMID: 33043894</identifier><identifier>CODEN: NNOTER</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; controlled drug release ; Drug Carriers - chemistry ; electrospinning ; Female ; HeLa Cells ; Humans ; Lignin - chemistry ; lignin nanoparticles ; Nanofibers - chemistry ; Paclitaxel - administration & dosage ; Paclitaxel - pharmacology ; Polyvinyl Alcohol - chemistry ; Povidone - chemistry ; targeted cervical cancer treatment ; Uterine Cervical Neoplasms - drug therapy</subject><ispartof>Nanotechnology, 2021-01, Vol.32 (1), p.015101-015101</ispartof><rights>2020 IOP Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-7aafeeb464cabdb64b1d6cf807331b3e2d420ae5fbfbf0521da2a27c88b163263</citedby><cites>FETCH-LOGICAL-c369t-7aafeeb464cabdb64b1d6cf807331b3e2d420ae5fbfbf0521da2a27c88b163263</cites><orcidid>0000-0001-7892-7381 ; 0000-0002-9542-3238</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1361-6528/abb55a/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,777,781,27905,27906,53827,53874</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33043894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Baoe</creatorcontrib><creatorcontrib>Xia, Xiaomei</creatorcontrib><creatorcontrib>Chen, Jiatian</creatorcontrib><creatorcontrib>Xia, Dan</creatorcontrib><creatorcontrib>Xu, Ruodan</creatorcontrib><creatorcontrib>Zou, Xianrui</creatorcontrib><creatorcontrib>Wang, Hongshui</creatorcontrib><creatorcontrib>Liang, Chunyong</creatorcontrib><title>Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition</title><title>Nanotechnology</title><addtitle>Nano</addtitle><addtitle>Nanotechnology</addtitle><description>Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has been fabricated into a composite nanofibrous membrane (PVA/PVP-PLNPs) for use as a drug carrier using the electrospinning technique. The fabricated PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability and biocompatibility. In vitro experiments showed that combining lignin nanoparticles by electrospinning not only improved the drug release profile, but also enhanced the hydrophilicity of nanofibrous membranes which was beneficial to cell adhesion and proliferation. Cellular experiments demonstrated that PVA/PVP-2%PLNPs membrane showed good cell inhibition ability, and the cell survival rate was only 21% at day 7. It indicates that the as-prepared PVA/PVP-PLNPs composite nanofibers are promising candidates for local anticancer therapy.</description><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>controlled drug release</subject><subject>Drug Carriers - chemistry</subject><subject>electrospinning</subject><subject>Female</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Lignin - chemistry</subject><subject>lignin nanoparticles</subject><subject>Nanofibers - chemistry</subject><subject>Paclitaxel - administration & dosage</subject><subject>Paclitaxel - pharmacology</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Povidone - chemistry</subject><subject>targeted cervical cancer treatment</subject><subject>Uterine Cervical Neoplasms - drug therapy</subject><issn>0957-4484</issn><issn>1361-6528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EokvLnRPysQfC-ivZ5FhV5UOq1D3QXq2xMwZXXjvYSQU_gX-Noy09ocqH8XieeeV5h5B3nH3krO-3XHa86VrRb8GYtoUXZPP09JJs2NDuGqV6dULelHLPGOe94K_JiZRMyX5QG_JnDzb4GX5haEKCEUca_PfoI50gz94GpBgtTGUJMNeij3OiGNDOOZVpiXR_d7Hd3-2pTYcpFT8jjRCT8wYzdSlTdK7C_gGpxfzgLQRqIdZ7zUOoej-88bNP8Yy8chAKvn2Mp-T209W3yy_N9c3nr5cX142V3TA3OwCHaFSnLJjRdMrwsbOuZzspuZEoRiUYYOtMPawVfAQBYmf73vBOik6ekvOj7pTTzwXLrA--rH-BiGkpWig1DIMaOlZRdkRtHbZkdHrK_gD5t-ZMrwvQq9t6dVsfF1Bb3j-qL-aA41PDP8cr8OEI-DTp-7TkWId9Tu_8P_hqsZZCc814yxnX0-jkXxcfoPg</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Li, Baoe</creator><creator>Xia, Xiaomei</creator><creator>Chen, Jiatian</creator><creator>Xia, Dan</creator><creator>Xu, Ruodan</creator><creator>Zou, Xianrui</creator><creator>Wang, Hongshui</creator><creator>Liang, Chunyong</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7892-7381</orcidid><orcidid>https://orcid.org/0000-0002-9542-3238</orcidid></search><sort><creationdate>20210101</creationdate><title>Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition</title><author>Li, Baoe ; Xia, Xiaomei ; Chen, Jiatian ; Xia, Dan ; Xu, Ruodan ; Zou, Xianrui ; Wang, Hongshui ; Liang, Chunyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-7aafeeb464cabdb64b1d6cf807331b3e2d420ae5fbfbf0521da2a27c88b163263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>controlled drug release</topic><topic>Drug Carriers - chemistry</topic><topic>electrospinning</topic><topic>Female</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Lignin - chemistry</topic><topic>lignin nanoparticles</topic><topic>Nanofibers - chemistry</topic><topic>Paclitaxel - administration & dosage</topic><topic>Paclitaxel - pharmacology</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Povidone - chemistry</topic><topic>targeted cervical cancer treatment</topic><topic>Uterine Cervical Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Baoe</creatorcontrib><creatorcontrib>Xia, Xiaomei</creatorcontrib><creatorcontrib>Chen, Jiatian</creatorcontrib><creatorcontrib>Xia, Dan</creatorcontrib><creatorcontrib>Xu, Ruodan</creatorcontrib><creatorcontrib>Zou, Xianrui</creatorcontrib><creatorcontrib>Wang, Hongshui</creatorcontrib><creatorcontrib>Liang, Chunyong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nanotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Baoe</au><au>Xia, Xiaomei</au><au>Chen, Jiatian</au><au>Xia, Dan</au><au>Xu, Ruodan</au><au>Zou, Xianrui</au><au>Wang, Hongshui</au><au>Liang, Chunyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition</atitle><jtitle>Nanotechnology</jtitle><stitle>Nano</stitle><addtitle>Nanotechnology</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>32</volume><issue>1</issue><spage>015101</spage><epage>015101</epage><pages>015101-015101</pages><issn>0957-4484</issn><eissn>1361-6528</eissn><coden>NNOTER</coden><abstract>Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has been fabricated into a composite nanofibrous membrane (PVA/PVP-PLNPs) for use as a drug carrier using the electrospinning technique. The fabricated PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability and biocompatibility. In vitro experiments showed that combining lignin nanoparticles by electrospinning not only improved the drug release profile, but also enhanced the hydrophilicity of nanofibrous membranes which was beneficial to cell adhesion and proliferation. Cellular experiments demonstrated that PVA/PVP-2%PLNPs membrane showed good cell inhibition ability, and the cell survival rate was only 21% at day 7. It indicates that the as-prepared PVA/PVP-PLNPs composite nanofibers are promising candidates for local anticancer therapy.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>33043894</pmid><doi>10.1088/1361-6528/abb55a</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7892-7381</orcidid><orcidid>https://orcid.org/0000-0002-9542-3238</orcidid></addata></record> |
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| subjects | Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology controlled drug release Drug Carriers - chemistry electrospinning Female HeLa Cells Humans Lignin - chemistry lignin nanoparticles Nanofibers - chemistry Paclitaxel - administration & dosage Paclitaxel - pharmacology Polyvinyl Alcohol - chemistry Povidone - chemistry targeted cervical cancer treatment Uterine Cervical Neoplasms - drug therapy |
| title | Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition |
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