Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group
Background In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. D...
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| Veröffentlicht in: | Clinical and experimental nephrology 2021-02, Vol.25 (2), p.173-183 |
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| creator | Aydin, Zeki Turkmen, Kultigin Dede, Fatih Yasar, Emre Ozturk, Savas Aydin, Mehmet Tatar, Erhan Sahin, Garip Manga, Gulizar Oto, Ozgur Sumnu, Abdullah Eroglu, Eray Dincer, Tamer Dursun, Belda Eren, Necmi Sevinc, Mustafa Guzel, Fatma Betul Yalin, Serkan Kutlay, Sim Apaydin, Suheyla Berktas, Haci Bayram Kazan, Sinan Dheir, Hamad Bora, Feyza Basturk, Taner Sahin, Idris |
| description | Background
In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated.
Methods
Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune).
Results
Of 3875 patients, 200 patients with RPGN (mean age 47.9 ± 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9–5.7) mg/dl, glomerular filtration rate was 18 (10–37) ml/min/1.73m
2
and proteinuria 2100 (1229–3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio.
Conclusions
Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed. |
| doi_str_mv | 10.1007/s10157-020-01978-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2449993001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449993001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-6d8e5f4a671c389db853865337c7c83a773d5a884cdd9290e7e9a3eabdd219633</originalsourceid><addsrcrecordid>eNp9kcFu1DAURSMEoqXwAyyQJTZFqsGOndhmhzowVBq1iw5iGXnsNxkXJw52gpT_4gPxdKYgsejqWfI518-6RfGakveUEPEhUUIrgUlJMKFKSFw_KU4pZwILodTTfGa8xFRU9KR4kdIdIUSqSj0vThgjnJS8Pi1-L6ALbdTDzpkLZLzrndEe6d4irzch6jHEGZmdjtqMEF0anUkobFFWnPUzGmLWISX3C1DrQwdx8qGHYRfd6BJyPVpP8QfMH--nSzt0G4yDcd6HXO-54EM74-XR1REtXAKdIKHz9e01Xt6sFu_Q95DlvkXLGKbhZfFsq32CV8d5Vnz78nl9-RWvbpZXl59W2PCKj7i2Eqot17WghkllN7Jisq4YE0YYybQQzFZaSm6sVaUiIEBpBnpjbUlVzdhZcX7IzZ_8OUEam84lA97rHsKUmpJzpRQjhGb07X_oXZhin7fLlJRCSC73geWBMjGkFGHbDNF1Os4NJc2-0-bQaZM7be47beosvTlGT5sO7F_locQMsAOQ8lXfQvz39iOxfwAWKa_i</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2488778483</pqid></control><display><type>article</type><title>Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group</title><source>SpringerNature Journals</source><creator>Aydin, Zeki ; Turkmen, Kultigin ; Dede, Fatih ; Yasar, Emre ; Ozturk, Savas ; Aydin, Mehmet ; Tatar, Erhan ; Sahin, Garip ; Manga, Gulizar ; Oto, Ozgur ; Sumnu, Abdullah ; Eroglu, Eray ; Dincer, Tamer ; Dursun, Belda ; Eren, Necmi ; Sevinc, Mustafa ; Guzel, Fatma Betul ; Yalin, Serkan ; Kutlay, Sim ; Apaydin, Suheyla ; Berktas, Haci Bayram ; Kazan, Sinan ; Dheir, Hamad ; Bora, Feyza ; Basturk, Taner ; Sahin, Idris</creator><creatorcontrib>Aydin, Zeki ; Turkmen, Kultigin ; Dede, Fatih ; Yasar, Emre ; Ozturk, Savas ; Aydin, Mehmet ; Tatar, Erhan ; Sahin, Garip ; Manga, Gulizar ; Oto, Ozgur ; Sumnu, Abdullah ; Eroglu, Eray ; Dincer, Tamer ; Dursun, Belda ; Eren, Necmi ; Sevinc, Mustafa ; Guzel, Fatma Betul ; Yalin, Serkan ; Kutlay, Sim ; Apaydin, Suheyla ; Berktas, Haci Bayram ; Kazan, Sinan ; Dheir, Hamad ; Bora, Feyza ; Basturk, Taner ; Sahin, Idris</creatorcontrib><description>Background
In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated.
Methods
Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune).
Results
Of 3875 patients, 200 patients with RPGN (mean age 47.9 ± 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9–5.7) mg/dl, glomerular filtration rate was 18 (10–37) ml/min/1.73m
2
and proteinuria 2100 (1229–3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio.
Conclusions
Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.</description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-020-01978-6</identifier><identifier>PMID: 33040246</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Antineutrophil cytoplasmic antibodies ; Biopsy ; Calcium ; Creatinine ; Diagnosis ; Glomerular filtration rate ; Glomerulonephritis ; Hemoglobin ; Immunosuppressive agents ; Laboratories ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Proteinuria ; Urea ; Urology ; Working groups</subject><ispartof>Clinical and experimental nephrology, 2021-02, Vol.25 (2), p.173-183</ispartof><rights>Japanese Society of Nephrology 2020</rights><rights>Japanese Society of Nephrology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-6d8e5f4a671c389db853865337c7c83a773d5a884cdd9290e7e9a3eabdd219633</citedby><cites>FETCH-LOGICAL-c454t-6d8e5f4a671c389db853865337c7c83a773d5a884cdd9290e7e9a3eabdd219633</cites><orcidid>0000-0001-8389-8271</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-020-01978-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-020-01978-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33040246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aydin, Zeki</creatorcontrib><creatorcontrib>Turkmen, Kultigin</creatorcontrib><creatorcontrib>Dede, Fatih</creatorcontrib><creatorcontrib>Yasar, Emre</creatorcontrib><creatorcontrib>Ozturk, Savas</creatorcontrib><creatorcontrib>Aydin, Mehmet</creatorcontrib><creatorcontrib>Tatar, Erhan</creatorcontrib><creatorcontrib>Sahin, Garip</creatorcontrib><creatorcontrib>Manga, Gulizar</creatorcontrib><creatorcontrib>Oto, Ozgur</creatorcontrib><creatorcontrib>Sumnu, Abdullah</creatorcontrib><creatorcontrib>Eroglu, Eray</creatorcontrib><creatorcontrib>Dincer, Tamer</creatorcontrib><creatorcontrib>Dursun, Belda</creatorcontrib><creatorcontrib>Eren, Necmi</creatorcontrib><creatorcontrib>Sevinc, Mustafa</creatorcontrib><creatorcontrib>Guzel, Fatma Betul</creatorcontrib><creatorcontrib>Yalin, Serkan</creatorcontrib><creatorcontrib>Kutlay, Sim</creatorcontrib><creatorcontrib>Apaydin, Suheyla</creatorcontrib><creatorcontrib>Berktas, Haci Bayram</creatorcontrib><creatorcontrib>Kazan, Sinan</creatorcontrib><creatorcontrib>Dheir, Hamad</creatorcontrib><creatorcontrib>Bora, Feyza</creatorcontrib><creatorcontrib>Basturk, Taner</creatorcontrib><creatorcontrib>Sahin, Idris</creatorcontrib><title>Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description>Background
In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated.
Methods
Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune).
Results
Of 3875 patients, 200 patients with RPGN (mean age 47.9 ± 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9–5.7) mg/dl, glomerular filtration rate was 18 (10–37) ml/min/1.73m
2
and proteinuria 2100 (1229–3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio.
Conclusions
Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.</description><subject>Antineutrophil cytoplasmic antibodies</subject><subject>Biopsy</subject><subject>Calcium</subject><subject>Creatinine</subject><subject>Diagnosis</subject><subject>Glomerular filtration rate</subject><subject>Glomerulonephritis</subject><subject>Hemoglobin</subject><subject>Immunosuppressive agents</subject><subject>Laboratories</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Proteinuria</subject><subject>Urea</subject><subject>Urology</subject><subject>Working groups</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcFu1DAURSMEoqXwAyyQJTZFqsGOndhmhzowVBq1iw5iGXnsNxkXJw52gpT_4gPxdKYgsejqWfI518-6RfGakveUEPEhUUIrgUlJMKFKSFw_KU4pZwILodTTfGa8xFRU9KR4kdIdIUSqSj0vThgjnJS8Pi1-L6ALbdTDzpkLZLzrndEe6d4irzch6jHEGZmdjtqMEF0anUkobFFWnPUzGmLWISX3C1DrQwdx8qGHYRfd6BJyPVpP8QfMH--nSzt0G4yDcd6HXO-54EM74-XR1REtXAKdIKHz9e01Xt6sFu_Q95DlvkXLGKbhZfFsq32CV8d5Vnz78nl9-RWvbpZXl59W2PCKj7i2Eqot17WghkllN7Jisq4YE0YYybQQzFZaSm6sVaUiIEBpBnpjbUlVzdhZcX7IzZ_8OUEam84lA97rHsKUmpJzpRQjhGb07X_oXZhin7fLlJRCSC73geWBMjGkFGHbDNF1Os4NJc2-0-bQaZM7be47beosvTlGT5sO7F_locQMsAOQ8lXfQvz39iOxfwAWKa_i</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Aydin, Zeki</creator><creator>Turkmen, Kultigin</creator><creator>Dede, Fatih</creator><creator>Yasar, Emre</creator><creator>Ozturk, Savas</creator><creator>Aydin, Mehmet</creator><creator>Tatar, Erhan</creator><creator>Sahin, Garip</creator><creator>Manga, Gulizar</creator><creator>Oto, Ozgur</creator><creator>Sumnu, Abdullah</creator><creator>Eroglu, Eray</creator><creator>Dincer, Tamer</creator><creator>Dursun, Belda</creator><creator>Eren, Necmi</creator><creator>Sevinc, Mustafa</creator><creator>Guzel, Fatma Betul</creator><creator>Yalin, Serkan</creator><creator>Kutlay, Sim</creator><creator>Apaydin, Suheyla</creator><creator>Berktas, Haci Bayram</creator><creator>Kazan, Sinan</creator><creator>Dheir, Hamad</creator><creator>Bora, Feyza</creator><creator>Basturk, Taner</creator><creator>Sahin, Idris</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8389-8271</orcidid></search><sort><creationdate>20210201</creationdate><title>Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group</title><author>Aydin, Zeki ; Turkmen, Kultigin ; Dede, Fatih ; Yasar, Emre ; Ozturk, Savas ; Aydin, Mehmet ; Tatar, Erhan ; Sahin, Garip ; Manga, Gulizar ; Oto, Ozgur ; Sumnu, Abdullah ; Eroglu, Eray ; Dincer, Tamer ; Dursun, Belda ; Eren, Necmi ; Sevinc, Mustafa ; Guzel, Fatma Betul ; Yalin, Serkan ; Kutlay, Sim ; Apaydin, Suheyla ; Berktas, Haci Bayram ; Kazan, Sinan ; Dheir, Hamad ; Bora, Feyza ; Basturk, Taner ; Sahin, Idris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-6d8e5f4a671c389db853865337c7c83a773d5a884cdd9290e7e9a3eabdd219633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antineutrophil cytoplasmic antibodies</topic><topic>Biopsy</topic><topic>Calcium</topic><topic>Creatinine</topic><topic>Diagnosis</topic><topic>Glomerular filtration rate</topic><topic>Glomerulonephritis</topic><topic>Hemoglobin</topic><topic>Immunosuppressive agents</topic><topic>Laboratories</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Proteinuria</topic><topic>Urea</topic><topic>Urology</topic><topic>Working groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aydin, Zeki</creatorcontrib><creatorcontrib>Turkmen, Kultigin</creatorcontrib><creatorcontrib>Dede, Fatih</creatorcontrib><creatorcontrib>Yasar, Emre</creatorcontrib><creatorcontrib>Ozturk, Savas</creatorcontrib><creatorcontrib>Aydin, Mehmet</creatorcontrib><creatorcontrib>Tatar, Erhan</creatorcontrib><creatorcontrib>Sahin, Garip</creatorcontrib><creatorcontrib>Manga, Gulizar</creatorcontrib><creatorcontrib>Oto, Ozgur</creatorcontrib><creatorcontrib>Sumnu, Abdullah</creatorcontrib><creatorcontrib>Eroglu, Eray</creatorcontrib><creatorcontrib>Dincer, Tamer</creatorcontrib><creatorcontrib>Dursun, Belda</creatorcontrib><creatorcontrib>Eren, Necmi</creatorcontrib><creatorcontrib>Sevinc, Mustafa</creatorcontrib><creatorcontrib>Guzel, Fatma Betul</creatorcontrib><creatorcontrib>Yalin, Serkan</creatorcontrib><creatorcontrib>Kutlay, Sim</creatorcontrib><creatorcontrib>Apaydin, Suheyla</creatorcontrib><creatorcontrib>Berktas, Haci Bayram</creatorcontrib><creatorcontrib>Kazan, Sinan</creatorcontrib><creatorcontrib>Dheir, Hamad</creatorcontrib><creatorcontrib>Bora, Feyza</creatorcontrib><creatorcontrib>Basturk, Taner</creatorcontrib><creatorcontrib>Sahin, Idris</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 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Kultigin</au><au>Dede, Fatih</au><au>Yasar, Emre</au><au>Ozturk, Savas</au><au>Aydin, Mehmet</au><au>Tatar, Erhan</au><au>Sahin, Garip</au><au>Manga, Gulizar</au><au>Oto, Ozgur</au><au>Sumnu, Abdullah</au><au>Eroglu, Eray</au><au>Dincer, Tamer</au><au>Dursun, Belda</au><au>Eren, Necmi</au><au>Sevinc, Mustafa</au><au>Guzel, Fatma Betul</au><au>Yalin, Serkan</au><au>Kutlay, Sim</au><au>Apaydin, Suheyla</au><au>Berktas, Haci Bayram</au><au>Kazan, Sinan</au><au>Dheir, Hamad</au><au>Bora, Feyza</au><au>Basturk, Taner</au><au>Sahin, Idris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>25</volume><issue>2</issue><spage>173</spage><epage>183</epage><pages>173-183</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><abstract>Background
In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated.
Methods
Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune).
Results
Of 3875 patients, 200 patients with RPGN (mean age 47.9 ± 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9–5.7) mg/dl, glomerular filtration rate was 18 (10–37) ml/min/1.73m
2
and proteinuria 2100 (1229–3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio.
Conclusions
Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>33040246</pmid><doi>10.1007/s10157-020-01978-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8389-8271</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical and experimental nephrology, 2021-02, Vol.25 (2), p.173-183 |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Antineutrophil cytoplasmic antibodies Biopsy Calcium Creatinine Diagnosis Glomerular filtration rate Glomerulonephritis Hemoglobin Immunosuppressive agents Laboratories Medicine Medicine & Public Health Nephrology Original Article Proteinuria Urea Urology Working groups |
| title | Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group |
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