Bakuchiol from Psoralea corylifolia L. Ameliorates acute kidney injury and improves survival in experimental polymicrobial sepsis

•Bakuchiol (BAK) improved survival and relieves clinical signs in polymicrobial sepsis.•BAK ameliorated acute kidney injury in polymicrobial sepsis.•BAK reduced bacterial load and inflammation during polymicrobial sepsis.•BAK attenuated renal oxidative stress in polymicrobial sepsis.•BAK inhibited s...

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Veröffentlicht in:	International immunopharmacology 2020-12, Vol.89, p.107000-107000, Article 107000
Hauptverfasser:	Wang, Jiazheng, Luo, Min, Shen, Jiafan, Liu, Zhiwen, Chen, Ying, Luo, Jie, Zeng, Zhiying, Deng, Dinling, Xiao, Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney injury Bakuchiol Inflammation Kidneys MAP kinase NF-κB protein Organs Oxidative stress Phenolic compounds Phenols Psoralea corylifolia Sepsis Signaling
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