High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis
Introduction Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, the role of PNI in non‐small cell lung cancer patients (NSCLC) with bone metastasis remains unclear. Objective To explore...
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| Veröffentlicht in: | The clinical respiratory journal 2021-02, Vol.15 (2), p.225-231 |
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| creator | Xu, Shanqi Cao, Shoubo Geng, Jianxiong Wang, Chunyan Meng, Qingwei Yu, Yan |
| description | Introduction
Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, the role of PNI in non‐small cell lung cancer patients (NSCLC) with bone metastasis remains unclear.
Objective
To explore the prognostic role of PNI in NSCLC patients with bone metastasis.
Methods
A retrospective analysis of 259 initially diagnosed NSCLC with bone metastasis was conducted. Univariate and multivariate analysis were used to assess the potential prognostic roles of parameters.
Results
The most common symptoms initially presented were cough and chest pain. Two hundred patients (77.2%) received the treatment of bisphosphonates. Patients with low PNI were found in 154 (59.5%) patients. Median survival time for all cases was 286 days. The median OS for patients with low and high PNI was 227 and 389 days, respectively. The 6‐month, 1‐year and 2‐year survival rates for patients with low PNI were 66.2%, 29.9% and 10.4% compared to 79.0%, 52.4% and 26.7% in patients with high PNI level. On univariate analysis, female patients, non‐smokers, high PNI and systematic chemotherapy (P |
| doi_str_mv | 10.1111/crj.13288 |
| format | Article |
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Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, the role of PNI in non‐small cell lung cancer patients (NSCLC) with bone metastasis remains unclear.
Objective
To explore the prognostic role of PNI in NSCLC patients with bone metastasis.
Methods
A retrospective analysis of 259 initially diagnosed NSCLC with bone metastasis was conducted. Univariate and multivariate analysis were used to assess the potential prognostic roles of parameters.
Results
The most common symptoms initially presented were cough and chest pain. Two hundred patients (77.2%) received the treatment of bisphosphonates. Patients with low PNI were found in 154 (59.5%) patients. Median survival time for all cases was 286 days. The median OS for patients with low and high PNI was 227 and 389 days, respectively. The 6‐month, 1‐year and 2‐year survival rates for patients with low PNI were 66.2%, 29.9% and 10.4% compared to 79.0%, 52.4% and 26.7% in patients with high PNI level. On univariate analysis, female patients, non‐smokers, high PNI and systematic chemotherapy (P < 0.05) were shown to be closely correlated with a better prognosis of NSCLC patients with bone metastasis. Only PNI (P = 0.002), systematic chemotherapy (P = 0.026) and distant metastasis number (P = 0.044) held statistical significance on multivariate analysis.
Conclusions
PNI represents a non‐invasive, efficiency and convenient biomarker of NSCLC patients with bone metastasis. High PNI, systematic chemotherapy and distant metastasis number <2 are independent positive prognostic factors of NSCLC patients with bone metastasis.</description><identifier>ISSN: 1752-6981</identifier><identifier>EISSN: 1752-699X</identifier><identifier>DOI: 10.1111/crj.13288</identifier><identifier>PMID: 33037791</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>bone metastasis ; Chemotherapy ; Lung cancer ; Medical prognosis ; Metastasis ; Multivariate analysis ; NSCLC ; prognosis ; prognostic nutritional index</subject><ispartof>The clinical respiratory journal, 2021-02, Vol.15 (2), p.225-231</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3538-fcb802864316606c9407f516eb6c57477b8cf802f6b739aaaa9448e887dd3e63</citedby><cites>FETCH-LOGICAL-c3538-fcb802864316606c9407f516eb6c57477b8cf802f6b739aaaa9448e887dd3e63</cites><orcidid>0000-0001-8018-090X ; 0000-0002-8840-9497</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcrj.13288$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcrj.13288$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcrj.13288$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33037791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Shanqi</creatorcontrib><creatorcontrib>Cao, Shoubo</creatorcontrib><creatorcontrib>Geng, Jianxiong</creatorcontrib><creatorcontrib>Wang, Chunyan</creatorcontrib><creatorcontrib>Meng, Qingwei</creatorcontrib><creatorcontrib>Yu, Yan</creatorcontrib><title>High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis</title><title>The clinical respiratory journal</title><addtitle>Clin Respir J</addtitle><description>Introduction
Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, the role of PNI in non‐small cell lung cancer patients (NSCLC) with bone metastasis remains unclear.
Objective
To explore the prognostic role of PNI in NSCLC patients with bone metastasis.
Methods
A retrospective analysis of 259 initially diagnosed NSCLC with bone metastasis was conducted. Univariate and multivariate analysis were used to assess the potential prognostic roles of parameters.
Results
The most common symptoms initially presented were cough and chest pain. Two hundred patients (77.2%) received the treatment of bisphosphonates. Patients with low PNI were found in 154 (59.5%) patients. Median survival time for all cases was 286 days. The median OS for patients with low and high PNI was 227 and 389 days, respectively. The 6‐month, 1‐year and 2‐year survival rates for patients with low PNI were 66.2%, 29.9% and 10.4% compared to 79.0%, 52.4% and 26.7% in patients with high PNI level. On univariate analysis, female patients, non‐smokers, high PNI and systematic chemotherapy (P < 0.05) were shown to be closely correlated with a better prognosis of NSCLC patients with bone metastasis. Only PNI (P = 0.002), systematic chemotherapy (P = 0.026) and distant metastasis number (P = 0.044) held statistical significance on multivariate analysis.
Conclusions
PNI represents a non‐invasive, efficiency and convenient biomarker of NSCLC patients with bone metastasis. High PNI, systematic chemotherapy and distant metastasis number <2 are independent positive prognostic factors of NSCLC patients with bone metastasis.</description><subject>bone metastasis</subject><subject>Chemotherapy</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>NSCLC</subject><subject>prognosis</subject><subject>prognostic nutritional index</subject><issn>1752-6981</issn><issn>1752-699X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kctKAzEUhoMoXqoLX0ACbuqimkxmcllK8VIRFXHhbsikmZoyk9Qk42Xn1p3P6JOYWhURPOQkB86Xn-T8AGxjtI9THCg_3cck43wJrGNWZAMqxO3yT83xGtgIYYpQwRkpVsEaIYgwJvA6eD01kzs4825iXYhGQdtFb6JxVjbQ2LF-gv2ri9EelAFKOHMh9R707wsJMkpG52Gd0jr7_vIWWtk0UOm0NZ2dQCWt0h7OZDTaxgAfTbyDlbMatjrKkJYJm2Cllk3QW19nD9wcH90MTwfnlyej4eH5QJGC8EGtKo4yTnOCKUVUiRyxusBUV1QVLGes4qpORE0rRoRMIfKca87ZeEw0JT3QX8imL9x3OsSyNWH-Umm160KZ5bkQNGMUJ3T3Dzp1nU-DmVMC55wijBK1t6CUdyF4XZczb1rpn0uMyrk9ZbKn_LQnsTtfil3V6vEP-e1HAg4WwKNp9PP_SuXw-mwh-QFcHpua</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Xu, Shanqi</creator><creator>Cao, Shoubo</creator><creator>Geng, Jianxiong</creator><creator>Wang, Chunyan</creator><creator>Meng, Qingwei</creator><creator>Yu, Yan</creator><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8018-090X</orcidid><orcidid>https://orcid.org/0000-0002-8840-9497</orcidid></search><sort><creationdate>202102</creationdate><title>High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis</title><author>Xu, Shanqi ; Cao, Shoubo ; Geng, Jianxiong ; Wang, Chunyan ; Meng, Qingwei ; Yu, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3538-fcb802864316606c9407f516eb6c57477b8cf802f6b739aaaa9448e887dd3e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>bone metastasis</topic><topic>Chemotherapy</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>NSCLC</topic><topic>prognosis</topic><topic>prognostic nutritional index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Shanqi</creatorcontrib><creatorcontrib>Cao, Shoubo</creatorcontrib><creatorcontrib>Geng, Jianxiong</creatorcontrib><creatorcontrib>Wang, Chunyan</creatorcontrib><creatorcontrib>Meng, Qingwei</creatorcontrib><creatorcontrib>Yu, Yan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The clinical respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Xu, Shanqi</au><au>Cao, Shoubo</au><au>Geng, Jianxiong</au><au>Wang, Chunyan</au><au>Meng, Qingwei</au><au>Yu, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis</atitle><jtitle>The clinical respiratory journal</jtitle><addtitle>Clin Respir J</addtitle><date>2021-02</date><risdate>2021</risdate><volume>15</volume><issue>2</issue><spage>225</spage><epage>231</epage><pages>225-231</pages><issn>1752-6981</issn><eissn>1752-699X</eissn><abstract>Introduction
Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, the role of PNI in non‐small cell lung cancer patients (NSCLC) with bone metastasis remains unclear.
Objective
To explore the prognostic role of PNI in NSCLC patients with bone metastasis.
Methods
A retrospective analysis of 259 initially diagnosed NSCLC with bone metastasis was conducted. Univariate and multivariate analysis were used to assess the potential prognostic roles of parameters.
Results
The most common symptoms initially presented were cough and chest pain. Two hundred patients (77.2%) received the treatment of bisphosphonates. Patients with low PNI were found in 154 (59.5%) patients. Median survival time for all cases was 286 days. The median OS for patients with low and high PNI was 227 and 389 days, respectively. The 6‐month, 1‐year and 2‐year survival rates for patients with low PNI were 66.2%, 29.9% and 10.4% compared to 79.0%, 52.4% and 26.7% in patients with high PNI level. On univariate analysis, female patients, non‐smokers, high PNI and systematic chemotherapy (P < 0.05) were shown to be closely correlated with a better prognosis of NSCLC patients with bone metastasis. Only PNI (P = 0.002), systematic chemotherapy (P = 0.026) and distant metastasis number (P = 0.044) held statistical significance on multivariate analysis.
Conclusions
PNI represents a non‐invasive, efficiency and convenient biomarker of NSCLC patients with bone metastasis. High PNI, systematic chemotherapy and distant metastasis number <2 are independent positive prognostic factors of NSCLC patients with bone metastasis.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>33037791</pmid><doi>10.1111/crj.13288</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8018-090X</orcidid><orcidid>https://orcid.org/0000-0002-8840-9497</orcidid></addata></record> |
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| subjects | bone metastasis Chemotherapy Lung cancer Medical prognosis Metastasis Multivariate analysis NSCLC prognosis prognostic nutritional index |
| title | High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis |
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