Validity of the patient health questionnaire-2 (PHQ-2) for the detection of depression in primary care in Colombia
•The Patient Health Questionnaire-2 (PHQ-2) was tested in a Colombian sample.•The gold standard was the MINI interview.•The PHQ-2 demonstrates acceptable psychometric performance.•We recommended to consider screening tests with better indicators. The PHQ-2 is a screening test for major depressive di...
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| Veröffentlicht in: | Journal of affective disorders 2021-01, Vol.278, p.576-582 |
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| container_title | Journal of affective disorders |
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| creator | Scoppetta, Orlando Cassiani-Miranda, Carlos Arturo Arocha-Díaz, Karen Nicolle Cabanzo-Arenas, Diego Fernando Campo-Arias, Adalberto |
| description | •The Patient Health Questionnaire-2 (PHQ-2) was tested in a Colombian sample.•The gold standard was the MINI interview.•The PHQ-2 demonstrates acceptable psychometric performance.•We recommended to consider screening tests with better indicators.
The PHQ-2 is a screening test for major depressive disorder (MDD) derived from PHQ-9, which has shown to be useful in the detection of cases of clinical significance in previous studies. The psychometric properties of PHQ-2 in the Colombian population are unknown.
PHQ-2 were assessed in 243 patients in general medical consultations using the Mini-International Neuropsychiatric Interview (MINI) as the gold standard. Internal consistency, convergent validity and criterion validity were calculated by analyzing the Receptor Operating Characteristics (ROC) and the area under the curve (AUC).
Cronbach's alpha and McDonald's omega coefficients were 0.71. Spearman's rho coefficients for correlations with PHQ-9 and HADS-D scores were 0.63 and 0.59 (p |
| doi_str_mv | 10.1016/j.jad.2020.09.096 |
| format | Article |
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The PHQ-2 is a screening test for major depressive disorder (MDD) derived from PHQ-9, which has shown to be useful in the detection of cases of clinical significance in previous studies. The psychometric properties of PHQ-2 in the Colombian population are unknown.
PHQ-2 were assessed in 243 patients in general medical consultations using the Mini-International Neuropsychiatric Interview (MINI) as the gold standard. Internal consistency, convergent validity and criterion validity were calculated by analyzing the Receptor Operating Characteristics (ROC) and the area under the curve (AUC).
Cronbach's alpha and McDonald's omega coefficients were 0.71. Spearman's rho coefficients for correlations with PHQ-9 and HADS-D scores were 0.63 and 0.59 (p<0.01). AUC was 0.89. The optimal cut point was ≥2 with the following indicators: sensitivity 0.87 specificity 0.74; Youden index 0.60; PPV 0.47; NPV 0.95; (LR+) 3.24; (LR-) 0.18 (95% CI 0.09-0.37). Kappa coefficient between PHQ-2 and MINI for depression was .458 and 0.46 for HADS-D.
Since this study was done with people attending hospital, which could has implications for the prevalence of depression, affecting the validity indicators of the instrument.
PHQ-2 show an acceptable test performance in the context of the study. However, the test could yield a considerable amount of false positives that would require specialized evaluation to establish a reliable diagnosis.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2020.09.096</identifier><identifier>PMID: 33032028</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Colombia ; Depression ; Depressive Disorder, Major - diagnosis ; Humans ; Mass Screening ; Patient Health Questionnaire ; PHQ-2 ; Primary Health Care ; Psychometrics ; Reproducibility of Results ; Screening ; Sensitivity and Specificity ; Surveys and Questionnaires</subject><ispartof>Journal of affective disorders, 2021-01, Vol.278, p.576-582</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-776eb028bab08dc9defeb9b9f09aaa6a267eae4dd4117fd033d19831b2f2e8bf3</citedby><cites>FETCH-LOGICAL-c353t-776eb028bab08dc9defeb9b9f09aaa6a267eae4dd4117fd033d19831b2f2e8bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2020.09.096$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33032028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scoppetta, Orlando</creatorcontrib><creatorcontrib>Cassiani-Miranda, Carlos Arturo</creatorcontrib><creatorcontrib>Arocha-Díaz, Karen Nicolle</creatorcontrib><creatorcontrib>Cabanzo-Arenas, Diego Fernando</creatorcontrib><creatorcontrib>Campo-Arias, Adalberto</creatorcontrib><title>Validity of the patient health questionnaire-2 (PHQ-2) for the detection of depression in primary care in Colombia</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>•The Patient Health Questionnaire-2 (PHQ-2) was tested in a Colombian sample.•The gold standard was the MINI interview.•The PHQ-2 demonstrates acceptable psychometric performance.•We recommended to consider screening tests with better indicators.
The PHQ-2 is a screening test for major depressive disorder (MDD) derived from PHQ-9, which has shown to be useful in the detection of cases of clinical significance in previous studies. The psychometric properties of PHQ-2 in the Colombian population are unknown.
PHQ-2 were assessed in 243 patients in general medical consultations using the Mini-International Neuropsychiatric Interview (MINI) as the gold standard. Internal consistency, convergent validity and criterion validity were calculated by analyzing the Receptor Operating Characteristics (ROC) and the area under the curve (AUC).
Cronbach's alpha and McDonald's omega coefficients were 0.71. Spearman's rho coefficients for correlations with PHQ-9 and HADS-D scores were 0.63 and 0.59 (p<0.01). AUC was 0.89. The optimal cut point was ≥2 with the following indicators: sensitivity 0.87 specificity 0.74; Youden index 0.60; PPV 0.47; NPV 0.95; (LR+) 3.24; (LR-) 0.18 (95% CI 0.09-0.37). Kappa coefficient between PHQ-2 and MINI for depression was .458 and 0.46 for HADS-D.
Since this study was done with people attending hospital, which could has implications for the prevalence of depression, affecting the validity indicators of the instrument.
PHQ-2 show an acceptable test performance in the context of the study. However, the test could yield a considerable amount of false positives that would require specialized evaluation to establish a reliable diagnosis.</description><subject>Colombia</subject><subject>Depression</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Humans</subject><subject>Mass Screening</subject><subject>Patient Health Questionnaire</subject><subject>PHQ-2</subject><subject>Primary Health Care</subject><subject>Psychometrics</subject><subject>Reproducibility of Results</subject><subject>Screening</subject><subject>Sensitivity and Specificity</subject><subject>Surveys and Questionnaires</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LYzEQhoO4aK3-AG8kl-7FqfloTxq8krK7CgV3Qb0N-ZjQlNOTmqSC_35zbPVSGAgTnneYeRC6pGRCCW1v1pO1dhNGGJkQWas9QiM6E7xhMyqO0agys4ZwJk7RWc5rQkgrBTlBp5zXX8LmI5RedBdcKO84elxWgLe6BOgLXoHuygq_7iCXEPtehwQNw9d_7_817Cf2MX3gDgrYARjyDrYJch660ONtChud3rHVCYZ-Ebu4MUGfox9edxkuDu8YPf_-9bS4b5aPfx4Wd8vG8hkvjRAtmLqj0YbMnZUOPBhppCdSa91q1grQMHVuSqnwjnDuqJxzaphnMDeej9H1fu42xY8z1CZkC12ne4i7rNh0KmVLBZcVpXvUpphzAq8OyytK1KBarVVVrQbVishabc1cHcbvzAbcV-LTbQVu9wDUI98CJJVtVWvBVZW2KBfDN-P_AwS3j8Y</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Scoppetta, Orlando</creator><creator>Cassiani-Miranda, Carlos Arturo</creator><creator>Arocha-Díaz, Karen Nicolle</creator><creator>Cabanzo-Arenas, Diego Fernando</creator><creator>Campo-Arias, Adalberto</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210101</creationdate><title>Validity of the patient health questionnaire-2 (PHQ-2) for the detection of depression in primary care in Colombia</title><author>Scoppetta, Orlando ; Cassiani-Miranda, Carlos Arturo ; Arocha-Díaz, Karen Nicolle ; Cabanzo-Arenas, Diego Fernando ; Campo-Arias, Adalberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-776eb028bab08dc9defeb9b9f09aaa6a267eae4dd4117fd033d19831b2f2e8bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Colombia</topic><topic>Depression</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Humans</topic><topic>Mass Screening</topic><topic>Patient Health Questionnaire</topic><topic>PHQ-2</topic><topic>Primary Health Care</topic><topic>Psychometrics</topic><topic>Reproducibility of Results</topic><topic>Screening</topic><topic>Sensitivity and Specificity</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scoppetta, Orlando</creatorcontrib><creatorcontrib>Cassiani-Miranda, Carlos Arturo</creatorcontrib><creatorcontrib>Arocha-Díaz, Karen Nicolle</creatorcontrib><creatorcontrib>Cabanzo-Arenas, Diego Fernando</creatorcontrib><creatorcontrib>Campo-Arias, Adalberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scoppetta, Orlando</au><au>Cassiani-Miranda, Carlos Arturo</au><au>Arocha-Díaz, Karen Nicolle</au><au>Cabanzo-Arenas, Diego Fernando</au><au>Campo-Arias, Adalberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validity of the patient health questionnaire-2 (PHQ-2) for the detection of depression in primary care in Colombia</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>278</volume><spage>576</spage><epage>582</epage><pages>576-582</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•The Patient Health Questionnaire-2 (PHQ-2) was tested in a Colombian sample.•The gold standard was the MINI interview.•The PHQ-2 demonstrates acceptable psychometric performance.•We recommended to consider screening tests with better indicators.
The PHQ-2 is a screening test for major depressive disorder (MDD) derived from PHQ-9, which has shown to be useful in the detection of cases of clinical significance in previous studies. The psychometric properties of PHQ-2 in the Colombian population are unknown.
PHQ-2 were assessed in 243 patients in general medical consultations using the Mini-International Neuropsychiatric Interview (MINI) as the gold standard. Internal consistency, convergent validity and criterion validity were calculated by analyzing the Receptor Operating Characteristics (ROC) and the area under the curve (AUC).
Cronbach's alpha and McDonald's omega coefficients were 0.71. Spearman's rho coefficients for correlations with PHQ-9 and HADS-D scores were 0.63 and 0.59 (p<0.01). AUC was 0.89. The optimal cut point was ≥2 with the following indicators: sensitivity 0.87 specificity 0.74; Youden index 0.60; PPV 0.47; NPV 0.95; (LR+) 3.24; (LR-) 0.18 (95% CI 0.09-0.37). Kappa coefficient between PHQ-2 and MINI for depression was .458 and 0.46 for HADS-D.
Since this study was done with people attending hospital, which could has implications for the prevalence of depression, affecting the validity indicators of the instrument.
PHQ-2 show an acceptable test performance in the context of the study. However, the test could yield a considerable amount of false positives that would require specialized evaluation to establish a reliable diagnosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33032028</pmid><doi>10.1016/j.jad.2020.09.096</doi><tpages>7</tpages></addata></record> |
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| subjects | Colombia Depression Depressive Disorder, Major - diagnosis Humans Mass Screening Patient Health Questionnaire PHQ-2 Primary Health Care Psychometrics Reproducibility of Results Screening Sensitivity and Specificity Surveys and Questionnaires |
| title | Validity of the patient health questionnaire-2 (PHQ-2) for the detection of depression in primary care in Colombia |
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