Sensitive detection of Cre-mediated recombination using droplet digital PCR reveals Tg(BGLAP-Cre) and Tg(DMP1-Cre) are active in multiple non-skeletal tissues

In humans, somatic activating mutations in PIK3CA are associated with skeletal overgrowth. In order to determine if activated PI3K signaling in bone cells causes overgrowth, we used Tg(BGLAP-Cre) and Tg(DMP1-Cre) mouse strains to somatically activate a disease-causing conditional Pik3ca allele (Pik3...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2021-01, Vol.142, p.115674-115674, Article 115674
Hauptverfasser:	Dasgupta, Krishnakali, Lessard, Samantha, Hann, Steven, Fowler, Megan E., Robling, Alexander G., Warman, Matthew L.
Format:	Artikel
Sprache:	eng
Schlagworte:	BGLAP Cre-recombination Mouse Osteoblasts Osteocalcin Osteocytes PIK3CA
Online-Zugang:	Volltext
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