Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults
Purpose The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population. Methods We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospe...
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| Veröffentlicht in: | Journal of neuro-oncology 2020-09, Vol.149 (3), p.523-532 |
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| creator | Wong, Jordan Goddard, Karen Laperriere, Normand Dang, Jennifer Bouffet, Eric Bartels, Ute Hodgson, David Tyldesley, Scott Hukin, Juliette Cheng, Sylvia Bedard, Philippe L. Lo, Andrea C. |
| description | Purpose
The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population.
Methods
We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospectively reviewed for hormone deficiency, ototoxicity, seizure disorder, visual deterioration, cerebrovascular events, second neoplasm, psychiatric illness, and neurocognitive impairment. Statistical analysis was performed for late toxicities to evaluate the influence of select factors.
Results
Our patient cohort included 112 patients with IGCTs; 84% of patients had a germinoma as opposed to a non-germinomatous germ cell tumor (NGGCT), median age at radiotherapy (RT) was 19 years, and median follow-up was 8.3 years. Of the 94 patients with germinoma, 32 (34%) received both chemotherapy and RT as part of their upfront treatment, while 62 (66%) received RT alone. All 18 patients with NGGCT received chemotherapy and RT. The most common late toxicity following IGCT treatments was physician-reported neurocognitive impairment, with a 10-year cumulative incidence (CI) of 38.5%. Ten-year CI of treatment-induced ototoxicity was 39.2% for patients who received cisplatin, compared to 3.6% for those who received carboplatin but no cisplatin (p |
| doi_str_mv | 10.1007/s11060-020-03642-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2449959401</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449959401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-955aa6603161c6a8d6d5a6e3411680925e533c6c9040ab2ce5262112329c84603</originalsourceid><addsrcrecordid>eNp9kE1rGzEQhkVIiZ2PP9BDEeTSy7Yz-tw9hpA2BUMvCeQQELJWNmt2V46khfrfR47dBHroYRDDPPNqeAj5jPANAfT3hAgKKmCluBKswhMyR6l5pbnmp2QOqHQlG_E0I-cpbQBAaI5nZMY5cFELmJPnRRjXNPs40Bz-dK7LOxpWtBtztC7asbM9Xe-nzvc9zdMQIs3R2zz4MReM2jb0PrnSJWrHlu7CVAJtO_U5XZJPK9snf3V8L8jjj7uH2_tq8fvnr9ubReW4lrlqpLRWKeCo0Clbt6qVVnkuEFUNDZNecu6Ua0CAXTLnJVMMkXHWuFqUvQvy9ZC7jeFl8imboUv7g-3ow5QME6JpigfAgl7_g27CFMdyXaE0as1ELQvFDpSLIaXoV2Ybu8HGnUEwe_fm4N4U9-bNvdlHfzlGT8vBt-8rf2UXgB-AVEZjsfrx939iXwEYTI13</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471772485</pqid></control><display><type>article</type><title>Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults</title><source>SpringerLink Journals</source><creator>Wong, Jordan ; Goddard, Karen ; Laperriere, Normand ; Dang, Jennifer ; Bouffet, Eric ; Bartels, Ute ; Hodgson, David ; Tyldesley, Scott ; Hukin, Juliette ; Cheng, Sylvia ; Bedard, Philippe L. ; Lo, Andrea C.</creator><creatorcontrib>Wong, Jordan ; Goddard, Karen ; Laperriere, Normand ; Dang, Jennifer ; Bouffet, Eric ; Bartels, Ute ; Hodgson, David ; Tyldesley, Scott ; Hukin, Juliette ; Cheng, Sylvia ; Bedard, Philippe L. ; Lo, Andrea C.</creatorcontrib><description>Purpose
The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population.
Methods
We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospectively reviewed for hormone deficiency, ototoxicity, seizure disorder, visual deterioration, cerebrovascular events, second neoplasm, psychiatric illness, and neurocognitive impairment. Statistical analysis was performed for late toxicities to evaluate the influence of select factors.
Results
Our patient cohort included 112 patients with IGCTs; 84% of patients had a germinoma as opposed to a non-germinomatous germ cell tumor (NGGCT), median age at radiotherapy (RT) was 19 years, and median follow-up was 8.3 years. Of the 94 patients with germinoma, 32 (34%) received both chemotherapy and RT as part of their upfront treatment, while 62 (66%) received RT alone. All 18 patients with NGGCT received chemotherapy and RT. The most common late toxicity following IGCT treatments was physician-reported neurocognitive impairment, with a 10-year cumulative incidence (CI) of 38.5%. Ten-year CI of treatment-induced ototoxicity was 39.2% for patients who received cisplatin, compared to 3.6% for those who received carboplatin but no cisplatin (p < 0.005). Suprasellar/hypothalamic tumor location was associated with 10-year CI of treatment-induced hormone deficiency (36.1 vs 6.2%, p < 0.005).
Conclusions
A significant proportion of AYAs treated for IGCTs experience late effects from treatment, including neurocognitive impairment, ototoxicity, and hormone deficiency. Suprasellar/hypothalamic tumor location and cisplatin were associated with a higher risk of treatment-induced hormone deficiency and ototoxicity, respectively.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-020-03642-1</identifier><identifier>PMID: 33034840</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Carboplatin ; Chemotherapy ; Cisplatin ; Clinical Study ; Cognition ; Hypothalamus ; Medicine ; Medicine & Public Health ; Neurology ; Oncology ; Ototoxicity ; Radiation therapy ; Seizures ; Statistical analysis ; Young adults</subject><ispartof>Journal of neuro-oncology, 2020-09, Vol.149 (3), p.523-532</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-955aa6603161c6a8d6d5a6e3411680925e533c6c9040ab2ce5262112329c84603</citedby><cites>FETCH-LOGICAL-c375t-955aa6603161c6a8d6d5a6e3411680925e533c6c9040ab2ce5262112329c84603</cites><orcidid>0000-0002-3253-1071</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-020-03642-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-020-03642-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33034840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Jordan</creatorcontrib><creatorcontrib>Goddard, Karen</creatorcontrib><creatorcontrib>Laperriere, Normand</creatorcontrib><creatorcontrib>Dang, Jennifer</creatorcontrib><creatorcontrib>Bouffet, Eric</creatorcontrib><creatorcontrib>Bartels, Ute</creatorcontrib><creatorcontrib>Hodgson, David</creatorcontrib><creatorcontrib>Tyldesley, Scott</creatorcontrib><creatorcontrib>Hukin, Juliette</creatorcontrib><creatorcontrib>Cheng, Sylvia</creatorcontrib><creatorcontrib>Bedard, Philippe L.</creatorcontrib><creatorcontrib>Lo, Andrea C.</creatorcontrib><title>Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Purpose
The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population.
Methods
We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospectively reviewed for hormone deficiency, ototoxicity, seizure disorder, visual deterioration, cerebrovascular events, second neoplasm, psychiatric illness, and neurocognitive impairment. Statistical analysis was performed for late toxicities to evaluate the influence of select factors.
Results
Our patient cohort included 112 patients with IGCTs; 84% of patients had a germinoma as opposed to a non-germinomatous germ cell tumor (NGGCT), median age at radiotherapy (RT) was 19 years, and median follow-up was 8.3 years. Of the 94 patients with germinoma, 32 (34%) received both chemotherapy and RT as part of their upfront treatment, while 62 (66%) received RT alone. All 18 patients with NGGCT received chemotherapy and RT. The most common late toxicity following IGCT treatments was physician-reported neurocognitive impairment, with a 10-year cumulative incidence (CI) of 38.5%. Ten-year CI of treatment-induced ototoxicity was 39.2% for patients who received cisplatin, compared to 3.6% for those who received carboplatin but no cisplatin (p < 0.005). Suprasellar/hypothalamic tumor location was associated with 10-year CI of treatment-induced hormone deficiency (36.1 vs 6.2%, p < 0.005).
Conclusions
A significant proportion of AYAs treated for IGCTs experience late effects from treatment, including neurocognitive impairment, ototoxicity, and hormone deficiency. Suprasellar/hypothalamic tumor location and cisplatin were associated with a higher risk of treatment-induced hormone deficiency and ototoxicity, respectively.</description><subject>Carboplatin</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Clinical Study</subject><subject>Cognition</subject><subject>Hypothalamus</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Ototoxicity</subject><subject>Radiation therapy</subject><subject>Seizures</subject><subject>Statistical analysis</subject><subject>Young adults</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1rGzEQhkVIiZ2PP9BDEeTSy7Yz-tw9hpA2BUMvCeQQELJWNmt2V46khfrfR47dBHroYRDDPPNqeAj5jPANAfT3hAgKKmCluBKswhMyR6l5pbnmp2QOqHQlG_E0I-cpbQBAaI5nZMY5cFELmJPnRRjXNPs40Bz-dK7LOxpWtBtztC7asbM9Xe-nzvc9zdMQIs3R2zz4MReM2jb0PrnSJWrHlu7CVAJtO_U5XZJPK9snf3V8L8jjj7uH2_tq8fvnr9ubReW4lrlqpLRWKeCo0Clbt6qVVnkuEFUNDZNecu6Ua0CAXTLnJVMMkXHWuFqUvQvy9ZC7jeFl8imboUv7g-3ow5QME6JpigfAgl7_g27CFMdyXaE0as1ELQvFDpSLIaXoV2Ybu8HGnUEwe_fm4N4U9-bNvdlHfzlGT8vBt-8rf2UXgB-AVEZjsfrx939iXwEYTI13</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Wong, Jordan</creator><creator>Goddard, Karen</creator><creator>Laperriere, Normand</creator><creator>Dang, Jennifer</creator><creator>Bouffet, Eric</creator><creator>Bartels, Ute</creator><creator>Hodgson, David</creator><creator>Tyldesley, Scott</creator><creator>Hukin, Juliette</creator><creator>Cheng, Sylvia</creator><creator>Bedard, Philippe L.</creator><creator>Lo, Andrea C.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3253-1071</orcidid></search><sort><creationdate>20200901</creationdate><title>Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults</title><author>Wong, Jordan ; Goddard, Karen ; Laperriere, Normand ; Dang, Jennifer ; Bouffet, Eric ; Bartels, Ute ; Hodgson, David ; Tyldesley, Scott ; Hukin, Juliette ; Cheng, Sylvia ; Bedard, Philippe L. ; Lo, Andrea C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-955aa6603161c6a8d6d5a6e3411680925e533c6c9040ab2ce5262112329c84603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Carboplatin</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Clinical Study</topic><topic>Cognition</topic><topic>Hypothalamus</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Ototoxicity</topic><topic>Radiation therapy</topic><topic>Seizures</topic><topic>Statistical analysis</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Jordan</creatorcontrib><creatorcontrib>Goddard, Karen</creatorcontrib><creatorcontrib>Laperriere, Normand</creatorcontrib><creatorcontrib>Dang, Jennifer</creatorcontrib><creatorcontrib>Bouffet, Eric</creatorcontrib><creatorcontrib>Bartels, Ute</creatorcontrib><creatorcontrib>Hodgson, David</creatorcontrib><creatorcontrib>Tyldesley, Scott</creatorcontrib><creatorcontrib>Hukin, Juliette</creatorcontrib><creatorcontrib>Cheng, Sylvia</creatorcontrib><creatorcontrib>Bedard, Philippe L.</creatorcontrib><creatorcontrib>Lo, Andrea C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Jordan</au><au>Goddard, Karen</au><au>Laperriere, Normand</au><au>Dang, Jennifer</au><au>Bouffet, Eric</au><au>Bartels, Ute</au><au>Hodgson, David</au><au>Tyldesley, Scott</au><au>Hukin, Juliette</au><au>Cheng, Sylvia</au><au>Bedard, Philippe L.</au><au>Lo, Andrea C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>149</volume><issue>3</issue><spage>523</spage><epage>532</epage><pages>523-532</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>Purpose
The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population.
Methods
We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospectively reviewed for hormone deficiency, ototoxicity, seizure disorder, visual deterioration, cerebrovascular events, second neoplasm, psychiatric illness, and neurocognitive impairment. Statistical analysis was performed for late toxicities to evaluate the influence of select factors.
Results
Our patient cohort included 112 patients with IGCTs; 84% of patients had a germinoma as opposed to a non-germinomatous germ cell tumor (NGGCT), median age at radiotherapy (RT) was 19 years, and median follow-up was 8.3 years. Of the 94 patients with germinoma, 32 (34%) received both chemotherapy and RT as part of their upfront treatment, while 62 (66%) received RT alone. All 18 patients with NGGCT received chemotherapy and RT. The most common late toxicity following IGCT treatments was physician-reported neurocognitive impairment, with a 10-year cumulative incidence (CI) of 38.5%. Ten-year CI of treatment-induced ototoxicity was 39.2% for patients who received cisplatin, compared to 3.6% for those who received carboplatin but no cisplatin (p < 0.005). Suprasellar/hypothalamic tumor location was associated with 10-year CI of treatment-induced hormone deficiency (36.1 vs 6.2%, p < 0.005).
Conclusions
A significant proportion of AYAs treated for IGCTs experience late effects from treatment, including neurocognitive impairment, ototoxicity, and hormone deficiency. Suprasellar/hypothalamic tumor location and cisplatin were associated with a higher risk of treatment-induced hormone deficiency and ototoxicity, respectively.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33034840</pmid><doi>10.1007/s11060-020-03642-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3253-1071</orcidid></addata></record> |
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| source | SpringerLink Journals |
| subjects | Carboplatin Chemotherapy Cisplatin Clinical Study Cognition Hypothalamus Medicine Medicine & Public Health Neurology Oncology Ototoxicity Radiation therapy Seizures Statistical analysis Young adults |
| title | Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults |
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