Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors
In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Jap...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2021-03, Vol.56 (3), p.646-654 |
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| creator | Morishima, Satoko Fukuda, Takahiro Doki, Noriko Mori, Takehiko Onizuka, Makoto Kawakita, Toshihiro Kato, Chiaki Ozawa, Yukiyasu Tanaka, Masatsugu Kurokawa, Mineo Kamimura, Tomohiko Inoue, Masami Tanaka, Junji Ichinohe, Tatsuo Atsuta, Yoshiko Morishima, Yasuo |
| description | In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II–IV acute GVHD (HR, 1.34; 95% CI, 1.13–1.59;
P
= 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II–IV (HR, 0.73; 95% CI, 0.62–0.87;
P
|
| doi_str_mv | 10.1038/s41409-020-01070-3 |
| format | Article |
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P
= 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II–IV (HR, 0.73; 95% CI, 0.62–0.87;
P
< 0.001) and III–IV acute GVHD (HR, 0.63; 95% CI, 0.46–0.87;
P
= 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05–1.43;
P
= 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/s41409-020-01070-3</identifier><identifier>PMID: 33037403</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/2056 ; 692/308/2171 ; Antigens ; Brothers and sisters ; Care and treatment ; Cell Biology ; Donors ; Genetic aspects ; Graft versus host reaction ; Health aspects ; Hematology ; Hematopoietic stem cells ; Histocompatibility antigen HLA ; Histocompatibility antigens ; HLA histocompatibility antigens ; Homografts ; Immunology ; Internal Medicine ; Leukemia ; Leukocytes ; Medicine ; Medicine & Public Health ; Myelodysplastic syndrome ; Myelodysplastic syndromes ; Patient outcomes ; Public Health ; Risk ; Risk factors ; Stem cell transplantation ; Stem Cells ; Transplantation ; Transplants ; Transplants & implants</subject><ispartof>Bone marrow transplantation (Basingstoke), 2021-03, Vol.56 (3), p.646-654</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-6f85a9d9355292a1e8abd28f4acfa626ed824dd7dac227e3f876a5332852be03</citedby><cites>FETCH-LOGICAL-c473t-6f85a9d9355292a1e8abd28f4acfa626ed824dd7dac227e3f876a5332852be03</cites><orcidid>0000-0002-7391-4271 ; 0000-0002-8176-4760 ; 0000-0003-4404-2870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41409-020-01070-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41409-020-01070-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33037403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morishima, Satoko</creatorcontrib><creatorcontrib>Fukuda, Takahiro</creatorcontrib><creatorcontrib>Doki, Noriko</creatorcontrib><creatorcontrib>Mori, Takehiko</creatorcontrib><creatorcontrib>Onizuka, Makoto</creatorcontrib><creatorcontrib>Kawakita, Toshihiro</creatorcontrib><creatorcontrib>Kato, Chiaki</creatorcontrib><creatorcontrib>Ozawa, Yukiyasu</creatorcontrib><creatorcontrib>Tanaka, Masatsugu</creatorcontrib><creatorcontrib>Kurokawa, Mineo</creatorcontrib><creatorcontrib>Kamimura, Tomohiko</creatorcontrib><creatorcontrib>Inoue, Masami</creatorcontrib><creatorcontrib>Tanaka, Junji</creatorcontrib><creatorcontrib>Ichinohe, Tatsuo</creatorcontrib><creatorcontrib>Atsuta, Yoshiko</creatorcontrib><creatorcontrib>Morishima, Yasuo</creatorcontrib><creatorcontrib>HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation</creatorcontrib><creatorcontrib>on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation</creatorcontrib><title>Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II–IV acute GVHD (HR, 1.34; 95% CI, 1.13–1.59;
P
= 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II–IV (HR, 0.73; 95% CI, 0.62–0.87;
P
< 0.001) and III–IV acute GVHD (HR, 0.63; 95% CI, 0.46–0.87;
P
= 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05–1.43;
P
= 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes.</description><subject>692/308/2056</subject><subject>692/308/2171</subject><subject>Antigens</subject><subject>Brothers and sisters</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Donors</subject><subject>Genetic aspects</subject><subject>Graft versus host reaction</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility antigens</subject><subject>HLA histocompatibility antigens</subject><subject>Homografts</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukocytes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myelodysplastic syndrome</subject><subject>Myelodysplastic syndromes</subject><subject>Patient outcomes</subject><subject>Public Health</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Transplantation</subject><subject>Transplants</subject><subject>Transplants & 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HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors</title><author>Morishima, Satoko ; Fukuda, Takahiro ; Doki, Noriko ; Mori, Takehiko ; Onizuka, Makoto ; Kawakita, Toshihiro ; Kato, Chiaki ; Ozawa, Yukiyasu ; Tanaka, Masatsugu ; Kurokawa, Mineo ; Kamimura, Tomohiko ; Inoue, Masami ; Tanaka, Junji ; Ichinohe, Tatsuo ; Atsuta, Yoshiko ; Morishima, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-6f85a9d9355292a1e8abd28f4acfa626ed824dd7dac227e3f876a5332852be03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/308/2056</topic><topic>692/308/2171</topic><topic>Antigens</topic><topic>Brothers and sisters</topic><topic>Care and treatment</topic><topic>Cell Biology</topic><topic>Donors</topic><topic>Genetic aspects</topic><topic>Graft versus host reaction</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hematopoietic stem cells</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility antigens</topic><topic>HLA histocompatibility antigens</topic><topic>Homografts</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Leukocytes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myelodysplastic syndrome</topic><topic>Myelodysplastic syndromes</topic><topic>Patient outcomes</topic><topic>Public Health</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Transplantation</topic><topic>Transplants</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morishima, Satoko</creatorcontrib><creatorcontrib>Fukuda, Takahiro</creatorcontrib><creatorcontrib>Doki, Noriko</creatorcontrib><creatorcontrib>Mori, 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Japan Society for Hematopoietic Cell Transplantation</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>56</volume><issue>3</issue><spage>646</spage><epage>654</epage><pages>646-654</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><abstract>In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II–IV acute GVHD (HR, 1.34; 95% CI, 1.13–1.59;
P
= 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II–IV (HR, 0.73; 95% CI, 0.62–0.87;
P
< 0.001) and III–IV acute GVHD (HR, 0.63; 95% CI, 0.46–0.87;
P
= 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05–1.43;
P
= 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33037403</pmid><doi>10.1038/s41409-020-01070-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7391-4271</orcidid><orcidid>https://orcid.org/0000-0002-8176-4760</orcidid><orcidid>https://orcid.org/0000-0003-4404-2870</orcidid></addata></record> |
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| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2021-03, Vol.56 (3), p.646-654 |
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| source | SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 692/308/2056 692/308/2171 Antigens Brothers and sisters Care and treatment Cell Biology Donors Genetic aspects Graft versus host reaction Health aspects Hematology Hematopoietic stem cells Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens Homografts Immunology Internal Medicine Leukemia Leukocytes Medicine Medicine & Public Health Myelodysplastic syndrome Myelodysplastic syndromes Patient outcomes Public Health Risk Risk factors Stem cell transplantation Stem Cells Transplantation Transplants Transplants & implants |
| title | Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors |
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