Cerebral microinfarcts disruption of remote cortical thickness
Cerebral microinfarcts (CMI) are common lesions, carrying an important contribution to small-vessel–related cognitive impairment. CMIs were previously found to cause local microstructural damage and disruption of white matter integrity. This study examines CMIs influence on cortical thickness in rem...
Gespeichert in:
| Veröffentlicht in: | Journal of the neurological sciences 2021-01, Vol.420, p.117170-117170, Article 117170 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 117170 |
|---|---|
| container_issue | |
| container_start_page | 117170 |
| container_title | Journal of the neurological sciences |
| container_volume | 420 |
| creator | Kraushar, D. Molad, J. Hallevi, H. Bornstein, N.M. Ben-Assayag, E. Auriel, E. |
| description | Cerebral microinfarcts (CMI) are common lesions, carrying an important contribution to small-vessel–related cognitive impairment. CMIs were previously found to cause local microstructural damage and disruption of white matter integrity. This study examines CMIs influence on cortical thickness in remote brain areas.
Six small silent diffuse weighted imaging (DWI) lesions corresponding to subacute CMI were identified among five patients who underwent baseline and follow-up MRI scans from the Tel-Aviv Acute Brain Stroke Cohort (TABASCO). Regions of interest (ROIs) corresponding to the site of the DWI lesions and of the non-lesioned contralateral hemisphere (control ROI) were co-registered. DTI tractography was additionally performed to reconstruct the white matter tracts containing the ROIs. The normalized cortical thickness was calculated for the DWI lesional tract as well as for the contralateral non-lesional tract, and the lesion-to-control cortical thickness ratio (CTR) was calculated.
Post-lesional scans, performed 25.1 ± 1.2 months after CMI detection, demonstrated reduced mean CTR within the ROI from 1.8 to 1.1 (p = 0.032). There was no difference between the CTR of the right hemisphere relative to those on the left hemisphere, or between the CTR change of the cortical and non-cortical CMI.
This study demonstrated the prolonged influence of CMI on cortical thickness in remote ROI. The total number of CMIs is difficult to determine, however it has been shown that detecting even a single CMI suggests the existence of hundreds to thousands lesions. Therefore, the cumulative impact of these widely distributed lesions on cerebral cortex may have a significant contribution to the development of vascular cognitive impairment.
•Cerebral microinfarcts (CMI) are very common small silent brain infarctions.•We examined CMIs influence on cortical thickness in remote areas.•Follow-up MRI demonstrated reduced cortical thickness in the region of interest.•This finding may imply that CMIs have a role in the mechanism of vascular dementia. |
| doi_str_mv | 10.1016/j.jns.2020.117170 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2449954360</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022510X20305062</els_id><sourcerecordid>2449954360</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-92bc87432f5f6b2e6c90a92265edcebfeed873ee7217e31672814a9e1915f6df3</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMozjj6A9xIl2465tGmCYIggy8YcKPgLrTpDaZOmzFJBf-9GTq6dHW58J0D50PonOAlwYRfdctuCEuKafpJRSp8gOZEVCIvhWCHaI4xpXlJ8NsMnYTQYYy5EPIYzRjDjApG5uhmBR4aX2-y3mrv7GBqr2PIWhv8uI3WDZkzmYfeRci089HqxMZ3qz8GCOEUHZl6E-Bsfxfo9f7uZfWYr58fnla361wzyWMuaaNFVTBqSsMbClxLXEtKeQmthsYAtKJiABUlFTDCKypIUUsgkqRAa9gCXU69W-8-RwhR9TZo2GzqAdwYFC0KKcuCcZxQMqFpTggejNp629f-WxGsdtpUp5I2tdOmJm0pc7GvH5se2r_Er6cEXE8ApJFfFrwK2sKgobUedFSts__U_wCoZH28</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449954360</pqid></control><display><type>article</type><title>Cerebral microinfarcts disruption of remote cortical thickness</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kraushar, D. ; Molad, J. ; Hallevi, H. ; Bornstein, N.M. ; Ben-Assayag, E. ; Auriel, E.</creator><creatorcontrib>Kraushar, D. ; Molad, J. ; Hallevi, H. ; Bornstein, N.M. ; Ben-Assayag, E. ; Auriel, E.</creatorcontrib><description>Cerebral microinfarcts (CMI) are common lesions, carrying an important contribution to small-vessel–related cognitive impairment. CMIs were previously found to cause local microstructural damage and disruption of white matter integrity. This study examines CMIs influence on cortical thickness in remote brain areas.
Six small silent diffuse weighted imaging (DWI) lesions corresponding to subacute CMI were identified among five patients who underwent baseline and follow-up MRI scans from the Tel-Aviv Acute Brain Stroke Cohort (TABASCO). Regions of interest (ROIs) corresponding to the site of the DWI lesions and of the non-lesioned contralateral hemisphere (control ROI) were co-registered. DTI tractography was additionally performed to reconstruct the white matter tracts containing the ROIs. The normalized cortical thickness was calculated for the DWI lesional tract as well as for the contralateral non-lesional tract, and the lesion-to-control cortical thickness ratio (CTR) was calculated.
Post-lesional scans, performed 25.1 ± 1.2 months after CMI detection, demonstrated reduced mean CTR within the ROI from 1.8 to 1.1 (p = 0.032). There was no difference between the CTR of the right hemisphere relative to those on the left hemisphere, or between the CTR change of the cortical and non-cortical CMI.
This study demonstrated the prolonged influence of CMI on cortical thickness in remote ROI. The total number of CMIs is difficult to determine, however it has been shown that detecting even a single CMI suggests the existence of hundreds to thousands lesions. Therefore, the cumulative impact of these widely distributed lesions on cerebral cortex may have a significant contribution to the development of vascular cognitive impairment.
•Cerebral microinfarcts (CMI) are very common small silent brain infarctions.•We examined CMIs influence on cortical thickness in remote areas.•Follow-up MRI demonstrated reduced cortical thickness in the region of interest.•This finding may imply that CMIs have a role in the mechanism of vascular dementia.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2020.117170</identifier><identifier>PMID: 33032831</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Brain ; Cerebral Cortex - diagnostic imaging ; CMI ; Cohort Studies ; DTI ; Humans ; Magnetic Resonance Imaging ; Microinfarct ; Stroke ; TABASCO ; Vascular cognitive impairment ; Vascular dementia</subject><ispartof>Journal of the neurological sciences, 2021-01, Vol.420, p.117170-117170, Article 117170</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-92bc87432f5f6b2e6c90a92265edcebfeed873ee7217e31672814a9e1915f6df3</citedby><cites>FETCH-LOGICAL-c396t-92bc87432f5f6b2e6c90a92265edcebfeed873ee7217e31672814a9e1915f6df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2020.117170$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33032831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraushar, D.</creatorcontrib><creatorcontrib>Molad, J.</creatorcontrib><creatorcontrib>Hallevi, H.</creatorcontrib><creatorcontrib>Bornstein, N.M.</creatorcontrib><creatorcontrib>Ben-Assayag, E.</creatorcontrib><creatorcontrib>Auriel, E.</creatorcontrib><title>Cerebral microinfarcts disruption of remote cortical thickness</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Cerebral microinfarcts (CMI) are common lesions, carrying an important contribution to small-vessel–related cognitive impairment. CMIs were previously found to cause local microstructural damage and disruption of white matter integrity. This study examines CMIs influence on cortical thickness in remote brain areas.
Six small silent diffuse weighted imaging (DWI) lesions corresponding to subacute CMI were identified among five patients who underwent baseline and follow-up MRI scans from the Tel-Aviv Acute Brain Stroke Cohort (TABASCO). Regions of interest (ROIs) corresponding to the site of the DWI lesions and of the non-lesioned contralateral hemisphere (control ROI) were co-registered. DTI tractography was additionally performed to reconstruct the white matter tracts containing the ROIs. The normalized cortical thickness was calculated for the DWI lesional tract as well as for the contralateral non-lesional tract, and the lesion-to-control cortical thickness ratio (CTR) was calculated.
Post-lesional scans, performed 25.1 ± 1.2 months after CMI detection, demonstrated reduced mean CTR within the ROI from 1.8 to 1.1 (p = 0.032). There was no difference between the CTR of the right hemisphere relative to those on the left hemisphere, or between the CTR change of the cortical and non-cortical CMI.
This study demonstrated the prolonged influence of CMI on cortical thickness in remote ROI. The total number of CMIs is difficult to determine, however it has been shown that detecting even a single CMI suggests the existence of hundreds to thousands lesions. Therefore, the cumulative impact of these widely distributed lesions on cerebral cortex may have a significant contribution to the development of vascular cognitive impairment.
•Cerebral microinfarcts (CMI) are very common small silent brain infarctions.•We examined CMIs influence on cortical thickness in remote areas.•Follow-up MRI demonstrated reduced cortical thickness in the region of interest.•This finding may imply that CMIs have a role in the mechanism of vascular dementia.</description><subject>Brain</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>CMI</subject><subject>Cohort Studies</subject><subject>DTI</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Microinfarct</subject><subject>Stroke</subject><subject>TABASCO</subject><subject>Vascular cognitive impairment</subject><subject>Vascular dementia</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMozjj6A9xIl2465tGmCYIggy8YcKPgLrTpDaZOmzFJBf-9GTq6dHW58J0D50PonOAlwYRfdctuCEuKafpJRSp8gOZEVCIvhWCHaI4xpXlJ8NsMnYTQYYy5EPIYzRjDjApG5uhmBR4aX2-y3mrv7GBqr2PIWhv8uI3WDZkzmYfeRci089HqxMZ3qz8GCOEUHZl6E-Bsfxfo9f7uZfWYr58fnla361wzyWMuaaNFVTBqSsMbClxLXEtKeQmthsYAtKJiABUlFTDCKypIUUsgkqRAa9gCXU69W-8-RwhR9TZo2GzqAdwYFC0KKcuCcZxQMqFpTggejNp629f-WxGsdtpUp5I2tdOmJm0pc7GvH5se2r_Er6cEXE8ApJFfFrwK2sKgobUedFSts__U_wCoZH28</recordid><startdate>20210115</startdate><enddate>20210115</enddate><creator>Kraushar, D.</creator><creator>Molad, J.</creator><creator>Hallevi, H.</creator><creator>Bornstein, N.M.</creator><creator>Ben-Assayag, E.</creator><creator>Auriel, E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210115</creationdate><title>Cerebral microinfarcts disruption of remote cortical thickness</title><author>Kraushar, D. ; Molad, J. ; Hallevi, H. ; Bornstein, N.M. ; Ben-Assayag, E. ; Auriel, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-92bc87432f5f6b2e6c90a92265edcebfeed873ee7217e31672814a9e1915f6df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brain</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>CMI</topic><topic>Cohort Studies</topic><topic>DTI</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Microinfarct</topic><topic>Stroke</topic><topic>TABASCO</topic><topic>Vascular cognitive impairment</topic><topic>Vascular dementia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraushar, D.</creatorcontrib><creatorcontrib>Molad, J.</creatorcontrib><creatorcontrib>Hallevi, H.</creatorcontrib><creatorcontrib>Bornstein, N.M.</creatorcontrib><creatorcontrib>Ben-Assayag, E.</creatorcontrib><creatorcontrib>Auriel, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraushar, D.</au><au>Molad, J.</au><au>Hallevi, H.</au><au>Bornstein, N.M.</au><au>Ben-Assayag, E.</au><au>Auriel, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral microinfarcts disruption of remote cortical thickness</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2021-01-15</date><risdate>2021</risdate><volume>420</volume><spage>117170</spage><epage>117170</epage><pages>117170-117170</pages><artnum>117170</artnum><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Cerebral microinfarcts (CMI) are common lesions, carrying an important contribution to small-vessel–related cognitive impairment. CMIs were previously found to cause local microstructural damage and disruption of white matter integrity. This study examines CMIs influence on cortical thickness in remote brain areas.
Six small silent diffuse weighted imaging (DWI) lesions corresponding to subacute CMI were identified among five patients who underwent baseline and follow-up MRI scans from the Tel-Aviv Acute Brain Stroke Cohort (TABASCO). Regions of interest (ROIs) corresponding to the site of the DWI lesions and of the non-lesioned contralateral hemisphere (control ROI) were co-registered. DTI tractography was additionally performed to reconstruct the white matter tracts containing the ROIs. The normalized cortical thickness was calculated for the DWI lesional tract as well as for the contralateral non-lesional tract, and the lesion-to-control cortical thickness ratio (CTR) was calculated.
Post-lesional scans, performed 25.1 ± 1.2 months after CMI detection, demonstrated reduced mean CTR within the ROI from 1.8 to 1.1 (p = 0.032). There was no difference between the CTR of the right hemisphere relative to those on the left hemisphere, or between the CTR change of the cortical and non-cortical CMI.
This study demonstrated the prolonged influence of CMI on cortical thickness in remote ROI. The total number of CMIs is difficult to determine, however it has been shown that detecting even a single CMI suggests the existence of hundreds to thousands lesions. Therefore, the cumulative impact of these widely distributed lesions on cerebral cortex may have a significant contribution to the development of vascular cognitive impairment.
•Cerebral microinfarcts (CMI) are very common small silent brain infarctions.•We examined CMIs influence on cortical thickness in remote areas.•Follow-up MRI demonstrated reduced cortical thickness in the region of interest.•This finding may imply that CMIs have a role in the mechanism of vascular dementia.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33032831</pmid><doi>10.1016/j.jns.2020.117170</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 2021-01, Vol.420, p.117170-117170, Article 117170 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2449954360 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Brain Cerebral Cortex - diagnostic imaging CMI Cohort Studies DTI Humans Magnetic Resonance Imaging Microinfarct Stroke TABASCO Vascular cognitive impairment Vascular dementia |
| title | Cerebral microinfarcts disruption of remote cortical thickness |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T21%3A43%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerebral%20microinfarcts%20disruption%20of%20remote%20cortical%20thickness&rft.jtitle=Journal%20of%20the%20neurological%20sciences&rft.au=Kraushar,%20D.&rft.date=2021-01-15&rft.volume=420&rft.spage=117170&rft.epage=117170&rft.pages=117170-117170&rft.artnum=117170&rft.issn=0022-510X&rft.eissn=1878-5883&rft_id=info:doi/10.1016/j.jns.2020.117170&rft_dat=%3Cproquest_cross%3E2449954360%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2449954360&rft_id=info:pmid/33032831&rft_els_id=S0022510X20305062&rfr_iscdi=true |