Growth hormone deficiency and replacement in children
Growth hormone deficiency (GHD) is a rare but treatable cause of short stature. The diagnosis requires a careful evaluation of clinical history, physical examination and appropriate interpretation of longitudinal growth, with specific features for each period of life. Other clinical findings, in add...
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| Veröffentlicht in: | Reviews in endocrine & metabolic disorders 2021-03, Vol.22 (1), p.101-108 |
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| creator | Boguszewski, Margaret C. S. |
| description | Growth hormone deficiency (GHD) is a rare but treatable cause of short stature. The diagnosis requires a careful evaluation of clinical history, physical examination and appropriate interpretation of longitudinal growth, with specific features for each period of life. Other clinical findings, in addition to growth failure, may be present and can be related to the etiology and to associated hormone deficiencies. Despite more than 50 years since the first reports of provocative tests of growth hormone (GH) secretion for the diagnosis of GHD, the interpretation of the results remains a matter of debate. When GHD is confirmed, GH treatment is recommended. Treatment is effective and safe, but requires daily injections during many years, which can affect adherence. At the end of longitudinal growth, during the transition phase, it might be necessary to re-evaluate GH secretion. This review summarizes and updates the recent information related to GHD in children, as well the recommendations for treatment. |
| doi_str_mv | 10.1007/s11154-020-09604-2 |
| format | Article |
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Treatment is effective and safe, but requires daily injections during many years, which can affect adherence. At the end of longitudinal growth, during the transition phase, it might be necessary to re-evaluate GH secretion. This review summarizes and updates the recent information related to GHD in children, as well the recommendations for treatment.</description><subject>Children</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Endocrinology</subject><subject>Etiology</subject><subject>Growth hormones</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Physical growth</subject><subject>Secretion</subject><issn>1389-9155</issn><issn>1573-2606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE9LwzAYh4Mobk6_gAcpePESzf82Rxk6hYEXPYc0fes62nQmHbJvb7RTwYOHkECe3-99eRA6p-SaEpLfREqpFJgwgolWRGB2gKZU5hwzRdRhevNCY02lnKCTGNeEMKq0PEYTzgnTOaVTJBehfx9W2aoPXe8hq6BuXAPe7TLrqyzAprUOOvBD1vjMrZq2CuBP0VFt2whn-3uGXu7vnucPePm0eJzfLrHjuRywUJbzirIcqHOSaeEEVUwT4VxluYayFArS4VCDc4rlupRK1qKSNhdaWD5DV2PvJvRvW4iD6ZrooG2th34bDRNCM6mEKhJ6-Qdd99vg03aGScKJKHiRJ4qNlAt9jAFqswlNZ8POUGI-pZpRqklSzZdUw1LoYl-9LTuofiLfFhPARyCmL_8K4Xf2P7UfbSeAVg</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Boguszewski, Margaret C. 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| issn | 1389-9155 1573-2606 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Children Diabetes Diagnosis Endocrinology Etiology Growth hormones Internal Medicine Medicine Medicine & Public Health Physical growth Secretion |
| title | Growth hormone deficiency and replacement in children |
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