Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples

Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples

Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some rel...

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Veröffentlicht in:Organic letters 2020-10, Vol.22 (20), p.7986-7990
Hauptverfasser: Luong, Huy X, Kim, Young-Woo
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creator Luong, Huy X
Kim, Young-Woo
description Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications.
doi_str_mv 10.1021/acs.orglett.0c02914
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title Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
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