Hand-held dynamometry for assessment of muscle strength in patients with inflammatory myopathies
Abstract Objectives Muscle weakness in idiopathic inflammatory myopathies (IIMs) is conventionally assessed using manual muscle testing (MMT). However, more objective tools must be developed to accurately and reliably quantify muscle strength in myositis patients. Hand-held dynamometry (HHD) is a qu...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2021-05, Vol.60 (5), p.2146-2156 |
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| creator | Saygin, Didem Oddis, Chester V Moghadam-Kia, Siamak Rockette-Wagner, Bonny Neiman, Nicole Koontz, Diane Aggarwal, Rohit |
| description | Abstract
Objectives
Muscle weakness in idiopathic inflammatory myopathies (IIMs) is conventionally assessed using manual muscle testing (MMT). However, more objective tools must be developed to accurately and reliably quantify muscle strength in myositis patients. Hand-held dynamometry (HHD) is a quantitative, portable device with reported reliability in neuromuscular disorders. Our aim was to assess the reliability, validity and responsiveness of HHD in myositis.
Methods
Myositis patients [DM, necrotizing myopathy (NM), PM and anti-synthetase syndrome] evaluated at the University of Pittsburgh myositis centre were prospectively enrolled. Each patient was assessed at 0, 3 and 6 months for validated outcome measures of myositis disease activity and physical function. At each visit, muscle strength was assessed using both MMT and HHD (Micro FET2, Hoggan Health Industries, Draper, UT, USA). The reliability, validity and responsiveness of the HHD was assessed using standard statistical methods.
Results
Fifty IIM patients (60% female; mean age 51.6 years; 6 PM, 9 NM, 24 DM and 11 anti-synthetase syndrome) were enrolled. HHD showed strong test–retest intrarater reliability (r = 0.96) and interrater reliability (r = 0.98). HHD correlated significantly with the MMT score (r = 0.48, P = 0.0006) and myositis disease activity and functional measures. Longitudinal analysis showed a significant and strong association between the HHD and MMT as well as 2016 ACR/EULAR myositis response criteria (r = 0.8, P |
| doi_str_mv | 10.1093/rheumatology/keaa419 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2449181614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/rheumatology/keaa419</oup_id><sourcerecordid>2449181614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2980-badfb0d72ef17106fa4e2f303396a3fdfe992268c426f5eafe20ceb107759b023</originalsourceid><addsrcrecordid>eNqNUEtPwzAMjhCIweAfIJQjl7K81jZHNAFDmsQFziVtnbXQNCNuhfrv6diYOHKy5e9h-yPkirNbzrSchQp6Zzrf-PUw-wBjFNdH5IyrWERMSnF86IWakHPEd8bYnMv0lEykZCJmKT8jb0vTllEFTUnLoTXOO-jCQK0P1CACooO2o95S12PRAMUuQLvuKlq3dGO6ekSRftU_A9sYt71o1LvBj2hVA16QE2sahMt9nZLXh_uXxTJaPT8-Le5WUSF0yqLclDZnZSLA8oSz2BoFwsrxER0baUsLWgsRp4USsZ2DsSBYATlnSTLXORNySm52vpvgP3vALnM1FtA0pgXfYyaU0jzlMVcjVe2oRfCIAWy2CbUzYcg4y7bZZn-zzfbZjrLr_YY-d1AeRL9hjoTZjuD7zf8svwG1v42d</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449181614</pqid></control><display><type>article</type><title>Hand-held dynamometry for assessment of muscle strength in patients with inflammatory myopathies</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Saygin, Didem ; Oddis, Chester V ; Moghadam-Kia, Siamak ; Rockette-Wagner, Bonny ; Neiman, Nicole ; Koontz, Diane ; Aggarwal, Rohit</creator><creatorcontrib>Saygin, Didem ; Oddis, Chester V ; Moghadam-Kia, Siamak ; Rockette-Wagner, Bonny ; Neiman, Nicole ; Koontz, Diane ; Aggarwal, Rohit</creatorcontrib><description>Abstract
Objectives
Muscle weakness in idiopathic inflammatory myopathies (IIMs) is conventionally assessed using manual muscle testing (MMT). However, more objective tools must be developed to accurately and reliably quantify muscle strength in myositis patients. Hand-held dynamometry (HHD) is a quantitative, portable device with reported reliability in neuromuscular disorders. Our aim was to assess the reliability, validity and responsiveness of HHD in myositis.
Methods
Myositis patients [DM, necrotizing myopathy (NM), PM and anti-synthetase syndrome] evaluated at the University of Pittsburgh myositis centre were prospectively enrolled. Each patient was assessed at 0, 3 and 6 months for validated outcome measures of myositis disease activity and physical function. At each visit, muscle strength was assessed using both MMT and HHD (Micro FET2, Hoggan Health Industries, Draper, UT, USA). The reliability, validity and responsiveness of the HHD was assessed using standard statistical methods.
Results
Fifty IIM patients (60% female; mean age 51.6 years; 6 PM, 9 NM, 24 DM and 11 anti-synthetase syndrome) were enrolled. HHD showed strong test–retest intrarater reliability (r = 0.96) and interrater reliability (r = 0.98). HHD correlated significantly with the MMT score (r = 0.48, P = 0.0006) and myositis disease activity and functional measures. Longitudinal analysis showed a significant and strong association between the HHD and MMT as well as 2016 ACR/EULAR myositis response criteria (r = 0.8, P < 0.0001) demonstrating responsiveness. The mean effect size and standardized response mean of HHD was large: 0.95 and 1.03, respectively. MMT had a high ceiling effect compared with HHD.
Conclusion
HHD demonstrated strong reliability, construct validity and responsiveness in myositis patients. External validation studies are required to confirm these findings.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keaa419</identifier><identifier>PMID: 33026081</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Humans ; Longitudinal Studies ; Muscle Strength - physiology ; Muscle Strength Dynamometer ; Muscle Weakness - physiopathology ; Myositis - physiopathology ; Prospective Studies</subject><ispartof>Rheumatology (Oxford, England), 2021-05, Vol.60 (5), p.2146-2156</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2980-badfb0d72ef17106fa4e2f303396a3fdfe992268c426f5eafe20ceb107759b023</citedby><cites>FETCH-LOGICAL-c2980-badfb0d72ef17106fa4e2f303396a3fdfe992268c426f5eafe20ceb107759b023</cites><orcidid>0000-0003-1675-597X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33026081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saygin, Didem</creatorcontrib><creatorcontrib>Oddis, Chester V</creatorcontrib><creatorcontrib>Moghadam-Kia, Siamak</creatorcontrib><creatorcontrib>Rockette-Wagner, Bonny</creatorcontrib><creatorcontrib>Neiman, Nicole</creatorcontrib><creatorcontrib>Koontz, Diane</creatorcontrib><creatorcontrib>Aggarwal, Rohit</creatorcontrib><title>Hand-held dynamometry for assessment of muscle strength in patients with inflammatory myopathies</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Abstract
Objectives
Muscle weakness in idiopathic inflammatory myopathies (IIMs) is conventionally assessed using manual muscle testing (MMT). However, more objective tools must be developed to accurately and reliably quantify muscle strength in myositis patients. Hand-held dynamometry (HHD) is a quantitative, portable device with reported reliability in neuromuscular disorders. Our aim was to assess the reliability, validity and responsiveness of HHD in myositis.
Methods
Myositis patients [DM, necrotizing myopathy (NM), PM and anti-synthetase syndrome] evaluated at the University of Pittsburgh myositis centre were prospectively enrolled. Each patient was assessed at 0, 3 and 6 months for validated outcome measures of myositis disease activity and physical function. At each visit, muscle strength was assessed using both MMT and HHD (Micro FET2, Hoggan Health Industries, Draper, UT, USA). The reliability, validity and responsiveness of the HHD was assessed using standard statistical methods.
Results
Fifty IIM patients (60% female; mean age 51.6 years; 6 PM, 9 NM, 24 DM and 11 anti-synthetase syndrome) were enrolled. HHD showed strong test–retest intrarater reliability (r = 0.96) and interrater reliability (r = 0.98). HHD correlated significantly with the MMT score (r = 0.48, P = 0.0006) and myositis disease activity and functional measures. Longitudinal analysis showed a significant and strong association between the HHD and MMT as well as 2016 ACR/EULAR myositis response criteria (r = 0.8, P < 0.0001) demonstrating responsiveness. The mean effect size and standardized response mean of HHD was large: 0.95 and 1.03, respectively. MMT had a high ceiling effect compared with HHD.
Conclusion
HHD demonstrated strong reliability, construct validity and responsiveness in myositis patients. External validation studies are required to confirm these findings.</description><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Muscle Strength - physiology</subject><subject>Muscle Strength Dynamometer</subject><subject>Muscle Weakness - physiopathology</subject><subject>Myositis - physiopathology</subject><subject>Prospective Studies</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUEtPwzAMjhCIweAfIJQjl7K81jZHNAFDmsQFziVtnbXQNCNuhfrv6diYOHKy5e9h-yPkirNbzrSchQp6Zzrf-PUw-wBjFNdH5IyrWERMSnF86IWakHPEd8bYnMv0lEykZCJmKT8jb0vTllEFTUnLoTXOO-jCQK0P1CACooO2o95S12PRAMUuQLvuKlq3dGO6ekSRftU_A9sYt71o1LvBj2hVA16QE2sahMt9nZLXh_uXxTJaPT8-Le5WUSF0yqLclDZnZSLA8oSz2BoFwsrxER0baUsLWgsRp4USsZ2DsSBYATlnSTLXORNySm52vpvgP3vALnM1FtA0pgXfYyaU0jzlMVcjVe2oRfCIAWy2CbUzYcg4y7bZZn-zzfbZjrLr_YY-d1AeRL9hjoTZjuD7zf8svwG1v42d</recordid><startdate>20210514</startdate><enddate>20210514</enddate><creator>Saygin, Didem</creator><creator>Oddis, Chester V</creator><creator>Moghadam-Kia, Siamak</creator><creator>Rockette-Wagner, Bonny</creator><creator>Neiman, Nicole</creator><creator>Koontz, Diane</creator><creator>Aggarwal, Rohit</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1675-597X</orcidid></search><sort><creationdate>20210514</creationdate><title>Hand-held dynamometry for assessment of muscle strength in patients with inflammatory myopathies</title><author>Saygin, Didem ; Oddis, Chester V ; Moghadam-Kia, Siamak ; Rockette-Wagner, Bonny ; Neiman, Nicole ; Koontz, Diane ; Aggarwal, Rohit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2980-badfb0d72ef17106fa4e2f303396a3fdfe992268c426f5eafe20ceb107759b023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Muscle Strength - physiology</topic><topic>Muscle Strength Dynamometer</topic><topic>Muscle Weakness - physiopathology</topic><topic>Myositis - physiopathology</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saygin, Didem</creatorcontrib><creatorcontrib>Oddis, Chester V</creatorcontrib><creatorcontrib>Moghadam-Kia, Siamak</creatorcontrib><creatorcontrib>Rockette-Wagner, Bonny</creatorcontrib><creatorcontrib>Neiman, Nicole</creatorcontrib><creatorcontrib>Koontz, Diane</creatorcontrib><creatorcontrib>Aggarwal, Rohit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saygin, Didem</au><au>Oddis, Chester V</au><au>Moghadam-Kia, Siamak</au><au>Rockette-Wagner, Bonny</au><au>Neiman, Nicole</au><au>Koontz, Diane</au><au>Aggarwal, Rohit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hand-held dynamometry for assessment of muscle strength in patients with inflammatory myopathies</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2021-05-14</date><risdate>2021</risdate><volume>60</volume><issue>5</issue><spage>2146</spage><epage>2156</epage><pages>2146-2156</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Abstract
Objectives
Muscle weakness in idiopathic inflammatory myopathies (IIMs) is conventionally assessed using manual muscle testing (MMT). However, more objective tools must be developed to accurately and reliably quantify muscle strength in myositis patients. Hand-held dynamometry (HHD) is a quantitative, portable device with reported reliability in neuromuscular disorders. Our aim was to assess the reliability, validity and responsiveness of HHD in myositis.
Methods
Myositis patients [DM, necrotizing myopathy (NM), PM and anti-synthetase syndrome] evaluated at the University of Pittsburgh myositis centre were prospectively enrolled. Each patient was assessed at 0, 3 and 6 months for validated outcome measures of myositis disease activity and physical function. At each visit, muscle strength was assessed using both MMT and HHD (Micro FET2, Hoggan Health Industries, Draper, UT, USA). The reliability, validity and responsiveness of the HHD was assessed using standard statistical methods.
Results
Fifty IIM patients (60% female; mean age 51.6 years; 6 PM, 9 NM, 24 DM and 11 anti-synthetase syndrome) were enrolled. HHD showed strong test–retest intrarater reliability (r = 0.96) and interrater reliability (r = 0.98). HHD correlated significantly with the MMT score (r = 0.48, P = 0.0006) and myositis disease activity and functional measures. Longitudinal analysis showed a significant and strong association between the HHD and MMT as well as 2016 ACR/EULAR myositis response criteria (r = 0.8, P < 0.0001) demonstrating responsiveness. The mean effect size and standardized response mean of HHD was large: 0.95 and 1.03, respectively. MMT had a high ceiling effect compared with HHD.
Conclusion
HHD demonstrated strong reliability, construct validity and responsiveness in myositis patients. External validation studies are required to confirm these findings.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>33026081</pmid><doi>10.1093/rheumatology/keaa419</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1675-597X</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Humans Longitudinal Studies Muscle Strength - physiology Muscle Strength Dynamometer Muscle Weakness - physiopathology Myositis - physiopathology Prospective Studies |
| title | Hand-held dynamometry for assessment of muscle strength in patients with inflammatory myopathies |
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