Effects of Wnt signaling on epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyp

BackgroundEpithelial to mesenchymal transition (EMT) is associated with the pathophysiology of chronic rhinosinusitis with nasal polyp (CRSwNP). Wnt signaling is causative for EMT, whereas the mechanism in CRSwNP is not fully understood.ObjectiveWe sought to evaluate the role of Wnt signaling in EMT...

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Veröffentlicht in:	Thorax 2020-11, Vol.75 (11), p.982-993
Hauptverfasser:	Bae, Jun-Sang, Ryu, Gwanghui, Kim, Ji Hye, Kim, Eun Hee, Rhee, Yun Hee, Chung, Young-Jun, Kim, Dae Woo, Lim, Suha, Chung, Phil-Sang, Shin, Hyun-Woo, Mo, Ji-Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adenomatous Polyposis Coli Protein airway epithelium Animals Asthma beta Catenin - metabolism Biomarkers - metabolism Cadherins - metabolism Cell adhesion & migration Chronic obstructive pulmonary disease Cyclin D1 - metabolism cytokine biology Cytokines Disease Models, Animal Epithelial-Mesenchymal Transition - physiology Gene expression histology/cytology Humans Indocyanine Green - pharmacology Inflammation innate immunity Mice Nasal Polyps - drug therapy Nasal Polyps - physiopathology Neutrophils Polyps Respiratory research Rhinitis Rhinitis - physiopathology Sinusitis Sinusitis - physiopathology Twist-Related Protein 1 - metabolism Up-Regulation Wnt Signaling Pathway - physiology
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