Pathogen‐associated molecular patterns and extracellular Hsp70 interplay in NLRP3 inflammasome activation in monocytic and bronchial epithelial cellular models of COPD exacerbations

During chronic obstructive pulmonary disease (COPD) exacerbations, interplay between pathogen‐associated molecular patterns (PAMPs; e.g. lipopolysaccharide (LPS) and lipoteichoic acid (LTA)) and damage‐associated molecular patterns (DAMPs; e.g. extracellular heat shock protein 70 (eHsp70) and adenos...

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Veröffentlicht in:	APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2021-02, Vol.129 (2), p.80-90
Hauptverfasser:	Rumora, Lada, Hlapčić, Iva, Hulina‐Tomašković, Andrea, Somborac‐Bačura, Anita, Bosnar, Martina, Rajković, Marija Grdić
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - metabolism Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology ATP Bacteria Bacterial diseases Cell Line Cell lines Chronic obstructive pulmonary disease COPD exacerbations Damage patterns Domains Epithelial cells extracellular Hsp70 Gene expression Heat shock proteins HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Immune response Immune system Inflammasomes Interleukin-1beta - metabolism Interleukins lipopolysaccharide Lipopolysaccharides Lipopolysaccharides - metabolism Lipoteichoic acid Lung diseases Macrophages Macrophages - metabolism Monocytes NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Nucleotides Obstructive lung disease Oligomerization Pathogen-Associated Molecular Pattern Molecules - metabolism Pathogens Pulmonary Disease, Chronic Obstructive - pathology Pyrin protein Teichoic Acids - metabolism THP-1 Cells
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