A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity

Drug-induced kidney injury is a major clinical problem and causes drug attrition in the pharmaceutical industry. To better predict drug-induced kidney injury, kidney in vitro cultures with enhanced physiologic relevance are developed. To mimic the proximal tubule, the main site of adverse drug react...

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Veröffentlicht in:	Drug metabolism and disposition 2020-12, Vol.48 (12), p.1303-1311
Hauptverfasser:	Nieskens, Tom T.G., Persson, Mikael, Kelly, Edward J., Sjögren, Anna-Karin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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