Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group
BACKGROUND AND PURPOSE:Enlarged perivascular spaces (EPVS) are considered subclinical markers of small vessel disease, associated with increased risk of stroke and dementia. Increasing evidence links chronic kidney disease (CKD) to small vessel disease. We explored the relationship between CKD and E...
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| Veröffentlicht in: | Stroke (1970) 2020-11, Vol.51 (11), p.3348-3351 |
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| container_title | Stroke (1970) |
| container_volume | 51 |
| creator | Penton, Ashley A. Lau, Helena Babikian, Viken L. Shulman, Julie Cervantes-Arslanian, Anna Gangadhara, Suhas Greer, David Aparicio, Hugo J. Romero, Jose R. |
| description | BACKGROUND AND PURPOSE:Enlarged perivascular spaces (EPVS) are considered subclinical markers of small vessel disease, associated with increased risk of stroke and dementia. Increasing evidence links chronic kidney disease (CKD) to small vessel disease. We explored the relationship between CKD and EPVS burden and the influence of racial group in this relation.
METHODS:Consecutive patients with stroke who underwent brain magnetic resonance imaging were included (n=894). Racial group was categorized as White, Black, or other (other racial groups). CKD was defined by glomerular filtration rate 3 months. EPVS were rated following a standardized method, dichotomized for analyses (mild [ |
| doi_str_mv | 10.1161/STROKEAHA.119.028688 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2448842973</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2448842973</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4478-4e29ac6ee8162719b2878373fa88db1d81acf52a10c1fa995d567e59735a92e53</originalsourceid><addsrcrecordid>eNqFUU1vEzEUtBCIhsI_QMhHLlv8tbv2MQppi1qpVVLEcfXifUtMnHWwvVQVfx5XKT3C4elp9GbmSTOEvOfsjPOGf1rfrW6ulvPLeYHmjAndaP2CzHgtVKUaoV-SGWPSVEIZc0LepPSDMSakrl-TEykZN9rUM_J7sY1hdJZeuX7EB_rZJYSEFBJdubSj52BziHQosxw9xO_Y01uM7hckOxVM1wewmKgb6S1kh2NO9JvLW7rOMeyKz9jTFfpyCiPNga7AOvD0Iobp8Ja8GsAnfPe0T8nX8-Xd4rK6vrn4sphfV1apVlcKhQHbIGreiJabjdCtlq0cQOt-w3vNwQ61AM4sH8CYuq-bFmvTyhqMwFqeko9H30MMPydMudu7ZNF7GDFMqRNKaa1EERSqOlJtDClFHLpDdHuIDx1n3WPs3XPsBZruGHuRfXj6MG322D-L_uZcCPpIuA8-Y0w7P91j7LYIPm__563-IS2dsrZpWSWYYJwXVD3W3Mg_12Ggcg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2448842973</pqid></control><display><type>article</type><title>Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Penton, Ashley A. ; Lau, Helena ; Babikian, Viken L. ; Shulman, Julie ; Cervantes-Arslanian, Anna ; Gangadhara, Suhas ; Greer, David ; Aparicio, Hugo J. ; Romero, Jose R.</creator><creatorcontrib>Penton, Ashley A. ; Lau, Helena ; Babikian, Viken L. ; Shulman, Julie ; Cervantes-Arslanian, Anna ; Gangadhara, Suhas ; Greer, David ; Aparicio, Hugo J. ; Romero, Jose R.</creatorcontrib><description>BACKGROUND AND PURPOSE:Enlarged perivascular spaces (EPVS) are considered subclinical markers of small vessel disease, associated with increased risk of stroke and dementia. Increasing evidence links chronic kidney disease (CKD) to small vessel disease. We explored the relationship between CKD and EPVS burden and the influence of racial group in this relation.
METHODS:Consecutive patients with stroke who underwent brain magnetic resonance imaging were included (n=894). Racial group was categorized as White, Black, or other (other racial groups). CKD was defined by glomerular filtration rate <60 mL/minute per 1.73 m for >3 months. EPVS were rated following a standardized method, dichotomized for analyses (mild [<20] versus severe [≥20]), and stratified by brain region (basal ganglia and centrum semiovale).
RESULTS:In multivariable-adjusted analysis, the association of CKD with severe EPVS varied across racial groups. Comparing patients with and without CKD within racial groups, we found that Whites with CKD had higher odds of severe centrum semiovale EPVS (odds ratio [OR], 2.41 [95% CI, 0.98–5.88]). Among patients with CKD, Black patients had higher odds of severe EPVS in the basal ganglia and centrum semiovale compared with Whites (OR, 1.93 [95% CI, 1.18–3.16] and OR, 1.90 [95% CI, 1.16–3.11], respectively) and other racial groups (OR, 2.03 [95% CI, 1.23–3.36] and OR, 2.02 [95% CI, 1.22–3.34], respectively).
CONCLUSIONS:CKD was more prevalent in our sample of patients with stroke with severe EPVS in the centrum semiovale. The relation differed when stratified by racial group and brain topography. Further studies are needed to confirm that CKD may relate differently to subclinical measures of small vessel disease according to race.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.119.028688</identifier><identifier>PMID: 33019895</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>African Americans - statistics & numerical data ; Aged ; Aged, 80 and over ; Basal Ganglia - diagnostic imaging ; Cerebral Small Vessel Diseases - diagnostic imaging ; Cerebral Small Vessel Diseases - epidemiology ; Cerebral Small Vessel Diseases - ethnology ; European Continental Ancestry Group - statistics & numerical data ; Female ; Glymphatic System - diagnostic imaging ; Hemorrhagic Stroke - epidemiology ; Humans ; Ischemic Attack, Transient - epidemiology ; Ischemic Stroke - epidemiology ; Lymphatic Diseases - diagnostic imaging ; Lymphatic Diseases - epidemiology ; Male ; Middle Aged ; Odds Ratio ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - ethnology ; Severity of Illness Index ; Stroke - epidemiology ; United States ; White Matter - diagnostic imaging</subject><ispartof>Stroke (1970), 2020-11, Vol.51 (11), p.3348-3351</ispartof><rights>American Heart Association, Inc.</rights><rights>2020 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4478-4e29ac6ee8162719b2878373fa88db1d81acf52a10c1fa995d567e59735a92e53</citedby><cites>FETCH-LOGICAL-c4478-4e29ac6ee8162719b2878373fa88db1d81acf52a10c1fa995d567e59735a92e53</cites><orcidid>0000-0002-2026-8333 ; 0000-0002-1101-2950</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33019895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penton, Ashley A.</creatorcontrib><creatorcontrib>Lau, Helena</creatorcontrib><creatorcontrib>Babikian, Viken L.</creatorcontrib><creatorcontrib>Shulman, Julie</creatorcontrib><creatorcontrib>Cervantes-Arslanian, Anna</creatorcontrib><creatorcontrib>Gangadhara, Suhas</creatorcontrib><creatorcontrib>Greer, David</creatorcontrib><creatorcontrib>Aparicio, Hugo J.</creatorcontrib><creatorcontrib>Romero, Jose R.</creatorcontrib><title>Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE:Enlarged perivascular spaces (EPVS) are considered subclinical markers of small vessel disease, associated with increased risk of stroke and dementia. Increasing evidence links chronic kidney disease (CKD) to small vessel disease. We explored the relationship between CKD and EPVS burden and the influence of racial group in this relation.
METHODS:Consecutive patients with stroke who underwent brain magnetic resonance imaging were included (n=894). Racial group was categorized as White, Black, or other (other racial groups). CKD was defined by glomerular filtration rate <60 mL/minute per 1.73 m for >3 months. EPVS were rated following a standardized method, dichotomized for analyses (mild [<20] versus severe [≥20]), and stratified by brain region (basal ganglia and centrum semiovale).
RESULTS:In multivariable-adjusted analysis, the association of CKD with severe EPVS varied across racial groups. Comparing patients with and without CKD within racial groups, we found that Whites with CKD had higher odds of severe centrum semiovale EPVS (odds ratio [OR], 2.41 [95% CI, 0.98–5.88]). Among patients with CKD, Black patients had higher odds of severe EPVS in the basal ganglia and centrum semiovale compared with Whites (OR, 1.93 [95% CI, 1.18–3.16] and OR, 1.90 [95% CI, 1.16–3.11], respectively) and other racial groups (OR, 2.03 [95% CI, 1.23–3.36] and OR, 2.02 [95% CI, 1.22–3.34], respectively).
CONCLUSIONS:CKD was more prevalent in our sample of patients with stroke with severe EPVS in the centrum semiovale. The relation differed when stratified by racial group and brain topography. Further studies are needed to confirm that CKD may relate differently to subclinical measures of small vessel disease according to race.</description><subject>African Americans - statistics & numerical data</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Basal Ganglia - diagnostic imaging</subject><subject>Cerebral Small Vessel Diseases - diagnostic imaging</subject><subject>Cerebral Small Vessel Diseases - epidemiology</subject><subject>Cerebral Small Vessel Diseases - ethnology</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Female</subject><subject>Glymphatic System - diagnostic imaging</subject><subject>Hemorrhagic Stroke - epidemiology</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - epidemiology</subject><subject>Ischemic Stroke - epidemiology</subject><subject>Lymphatic Diseases - diagnostic imaging</subject><subject>Lymphatic Diseases - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - ethnology</subject><subject>Severity of Illness Index</subject><subject>Stroke - epidemiology</subject><subject>United States</subject><subject>White Matter - diagnostic imaging</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1vEzEUtBCIhsI_QMhHLlv8tbv2MQppi1qpVVLEcfXifUtMnHWwvVQVfx5XKT3C4elp9GbmSTOEvOfsjPOGf1rfrW6ulvPLeYHmjAndaP2CzHgtVKUaoV-SGWPSVEIZc0LepPSDMSakrl-TEykZN9rUM_J7sY1hdJZeuX7EB_rZJYSEFBJdubSj52BziHQosxw9xO_Y01uM7hckOxVM1wewmKgb6S1kh2NO9JvLW7rOMeyKz9jTFfpyCiPNga7AOvD0Iobp8Ja8GsAnfPe0T8nX8-Xd4rK6vrn4sphfV1apVlcKhQHbIGreiJabjdCtlq0cQOt-w3vNwQ61AM4sH8CYuq-bFmvTyhqMwFqeko9H30MMPydMudu7ZNF7GDFMqRNKaa1EERSqOlJtDClFHLpDdHuIDx1n3WPs3XPsBZruGHuRfXj6MG322D-L_uZcCPpIuA8-Y0w7P91j7LYIPm__563-IS2dsrZpWSWYYJwXVD3W3Mg_12Ggcg</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Penton, Ashley A.</creator><creator>Lau, Helena</creator><creator>Babikian, Viken L.</creator><creator>Shulman, Julie</creator><creator>Cervantes-Arslanian, Anna</creator><creator>Gangadhara, Suhas</creator><creator>Greer, David</creator><creator>Aparicio, Hugo J.</creator><creator>Romero, Jose R.</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2026-8333</orcidid><orcidid>https://orcid.org/0000-0002-1101-2950</orcidid></search><sort><creationdate>20201101</creationdate><title>Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group</title><author>Penton, Ashley A. ; Lau, Helena ; Babikian, Viken L. ; Shulman, Julie ; Cervantes-Arslanian, Anna ; Gangadhara, Suhas ; Greer, David ; Aparicio, Hugo J. ; Romero, Jose R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4478-4e29ac6ee8162719b2878373fa88db1d81acf52a10c1fa995d567e59735a92e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>African Americans - statistics & numerical data</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Basal Ganglia - diagnostic imaging</topic><topic>Cerebral Small Vessel Diseases - diagnostic imaging</topic><topic>Cerebral Small Vessel Diseases - epidemiology</topic><topic>Cerebral Small Vessel Diseases - ethnology</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>Female</topic><topic>Glymphatic System - diagnostic imaging</topic><topic>Hemorrhagic Stroke - epidemiology</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - epidemiology</topic><topic>Ischemic Stroke - epidemiology</topic><topic>Lymphatic Diseases - diagnostic imaging</topic><topic>Lymphatic Diseases - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - ethnology</topic><topic>Severity of Illness Index</topic><topic>Stroke - epidemiology</topic><topic>United States</topic><topic>White Matter - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penton, Ashley A.</creatorcontrib><creatorcontrib>Lau, Helena</creatorcontrib><creatorcontrib>Babikian, Viken L.</creatorcontrib><creatorcontrib>Shulman, Julie</creatorcontrib><creatorcontrib>Cervantes-Arslanian, Anna</creatorcontrib><creatorcontrib>Gangadhara, Suhas</creatorcontrib><creatorcontrib>Greer, David</creatorcontrib><creatorcontrib>Aparicio, Hugo J.</creatorcontrib><creatorcontrib>Romero, Jose R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penton, Ashley A.</au><au>Lau, Helena</au><au>Babikian, Viken L.</au><au>Shulman, Julie</au><au>Cervantes-Arslanian, Anna</au><au>Gangadhara, Suhas</au><au>Greer, David</au><au>Aparicio, Hugo J.</au><au>Romero, Jose R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>51</volume><issue>11</issue><spage>3348</spage><epage>3351</epage><pages>3348-3351</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>BACKGROUND AND PURPOSE:Enlarged perivascular spaces (EPVS) are considered subclinical markers of small vessel disease, associated with increased risk of stroke and dementia. Increasing evidence links chronic kidney disease (CKD) to small vessel disease. We explored the relationship between CKD and EPVS burden and the influence of racial group in this relation.
METHODS:Consecutive patients with stroke who underwent brain magnetic resonance imaging were included (n=894). Racial group was categorized as White, Black, or other (other racial groups). CKD was defined by glomerular filtration rate <60 mL/minute per 1.73 m for >3 months. EPVS were rated following a standardized method, dichotomized for analyses (mild [<20] versus severe [≥20]), and stratified by brain region (basal ganglia and centrum semiovale).
RESULTS:In multivariable-adjusted analysis, the association of CKD with severe EPVS varied across racial groups. Comparing patients with and without CKD within racial groups, we found that Whites with CKD had higher odds of severe centrum semiovale EPVS (odds ratio [OR], 2.41 [95% CI, 0.98–5.88]). Among patients with CKD, Black patients had higher odds of severe EPVS in the basal ganglia and centrum semiovale compared with Whites (OR, 1.93 [95% CI, 1.18–3.16] and OR, 1.90 [95% CI, 1.16–3.11], respectively) and other racial groups (OR, 2.03 [95% CI, 1.23–3.36] and OR, 2.02 [95% CI, 1.22–3.34], respectively).
CONCLUSIONS:CKD was more prevalent in our sample of patients with stroke with severe EPVS in the centrum semiovale. The relation differed when stratified by racial group and brain topography. Further studies are needed to confirm that CKD may relate differently to subclinical measures of small vessel disease according to race.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>33019895</pmid><doi>10.1161/STROKEAHA.119.028688</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-2026-8333</orcidid><orcidid>https://orcid.org/0000-0002-1101-2950</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | African Americans - statistics & numerical data Aged Aged, 80 and over Basal Ganglia - diagnostic imaging Cerebral Small Vessel Diseases - diagnostic imaging Cerebral Small Vessel Diseases - epidemiology Cerebral Small Vessel Diseases - ethnology European Continental Ancestry Group - statistics & numerical data Female Glymphatic System - diagnostic imaging Hemorrhagic Stroke - epidemiology Humans Ischemic Attack, Transient - epidemiology Ischemic Stroke - epidemiology Lymphatic Diseases - diagnostic imaging Lymphatic Diseases - epidemiology Male Middle Aged Odds Ratio Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - ethnology Severity of Illness Index Stroke - epidemiology United States White Matter - diagnostic imaging |
| title | Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group |
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