Optimal levofloxacin dosing regimens in critically ill patients with acute kidney injury receiving continuous renal replacement therapy

To determine appropriate dosing of levofloxacin in critically ill patients receiving continuous renal replacement therapy (CRRT). All necessary pharmacokinetic and pharmacodynamic parameters from critically ill patients were obtained to develop mathematical models with first order elimination. Levof...

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Veröffentlicht in:	Journal of critical care 2021-06, Vol.63, p.154-160
Hauptverfasser:	Rungkitwattanakul, Dhakrit, Chaijamorn, Weerachai, Charoensareerat, Taniya, Charntrakarn, Pratarn, Khamkampud, Orapan, Rattanaponpasert, Nakumporn, Srisawat, Nattachai, Pattharachayakul, Sutthiporn
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Continuous renal replacement therapy Critically ill patients Dialysate Drug dosages Drug dosing Effluents Hemodialysis Intensive care Kidneys Levofloxacin Monte Carlo simulation Monte Carlo simulations Mortality Pharmacodynamics Pharmacokinetics Pneumonia Renal replacement therapy Streptococcus infections
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