Immune response to Leishmania mexicana: the host–parasite relationship
ABSTRACT Leishmaniosis is currently considered a serious public health problem and it is listed as a neglected tropical disease by World Health Organization (WHO). Despite the efforts of the scientific community, it has not been possible to develop an effective vaccine. Current treatment consists of...
Gespeichert in:
| Veröffentlicht in: | Pathogens and Disease 2020-11, Vol.78 (8), p.1, Article 060 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 1 |
| container_title | Pathogens and Disease |
| container_volume | 78 |
| creator | Rodríguez-Serrato, Mayra A Salinas-Carmona, Mario C Limón-Flores, Alberto Yairh |
| description | ABSTRACT
Leishmaniosis is currently considered a serious public health problem and it is listed as a neglected tropical disease by World Health Organization (WHO). Despite the efforts of the scientific community, it has not been possible to develop an effective vaccine. Current treatment consists of antimonials that is expensive and can cause adverse effects. It is essential to fully understand the immunopathogenesis of the disease to develop new strategies to prevent, treat and eradicate the disease. Studies on animal models have shown a new paradigm in the resolution or establishment of infection by Leishmania mexicana where a wide range of cytokines, antibodies and cells are involved. In recent years, the possibility of a new therapy with monoclonal antibodies has been considered, where isotype, specificity and concentration are critical for effective therapy. Would be better to create/generate a vaccine to induce host protection or produce passive immunization with engineering monoclonal antibodies to a defined antigen? This review provides an overview that includes the current known information on the immune response that are involved in the complex host–parasite relationship infection caused by L. mexicana.
This review describes the latest studies on the immunological knowledge of infection caused by Leishmania mexicana and, addresses the role of antibodies as a possible therapeutic strategy. |
| doi_str_mv | 10.1093/femspd/ftaa060 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_TOX</sourceid><recordid>TN_cdi_proquest_miscellaneous_2448642804</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A691104294</galeid><oup_id>10.1093/femspd/ftaa060</oup_id><sourcerecordid>A691104294</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-4a296e1b497376fd8b41dadd547e553d5217494b9f35dfb6dde1c3614cfb0a4e3</originalsourceid><addsrcrecordid>eNqNkcFqFTEUhgex2NJ261IG3Chy22RyJjNxVy7VFi50o-BuyCQn3pRJMk4yVHe-Q9_QJzHXuVZxYxNIQvj-ww9fUTyn5IwSwc4Nujjqc5OkJJw8KY4qAmLFWfXp6V_vw-I0xluSV1vTtuHPikPGCOWMVkfF1bVzs8dywjgGH7FModygjVsnvZWlw69WSS_flmmL5TbE9OP7_SgnGW3ahQaZbI5t7XhSHBg5RDzd38fFx3eXH9ZXq83N--v1xWaloIK0AlkJjrQH0bCGG932QLXUuoYG65rpuqINCOiFYbU2PdcaqWKcgjI9kYDsuHi1zB2n8GXGmDpno8JhkB7DHLsKoOVQtQQy-vIf9DbMk8_tMtVQkg_gmTpbqM9ywM56E9IkVd4anVXBo7H5_4ILSglUAv4E1BRinNB042SdnL51lHQ7L93ipdt7yYEX-x5z71A_4L8tZODNAtxhH0xUFr3CByyLqwVjAsTOYZ3p9vH02qZfitZh9ilHXy_RMI__a_0TObK6QA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471024746</pqid></control><display><type>article</type><title>Immune response to Leishmania mexicana: the host–parasite relationship</title><source>Access via Oxford University Press (Open Access Collection)</source><creator>Rodríguez-Serrato, Mayra A ; Salinas-Carmona, Mario C ; Limón-Flores, Alberto Yairh</creator><creatorcontrib>Rodríguez-Serrato, Mayra A ; Salinas-Carmona, Mario C ; Limón-Flores, Alberto Yairh</creatorcontrib><description>ABSTRACT
Leishmaniosis is currently considered a serious public health problem and it is listed as a neglected tropical disease by World Health Organization (WHO). Despite the efforts of the scientific community, it has not been possible to develop an effective vaccine. Current treatment consists of antimonials that is expensive and can cause adverse effects. It is essential to fully understand the immunopathogenesis of the disease to develop new strategies to prevent, treat and eradicate the disease. Studies on animal models have shown a new paradigm in the resolution or establishment of infection by Leishmania mexicana where a wide range of cytokines, antibodies and cells are involved. In recent years, the possibility of a new therapy with monoclonal antibodies has been considered, where isotype, specificity and concentration are critical for effective therapy. Would be better to create/generate a vaccine to induce host protection or produce passive immunization with engineering monoclonal antibodies to a defined antigen? This review provides an overview that includes the current known information on the immune response that are involved in the complex host–parasite relationship infection caused by L. mexicana.
This review describes the latest studies on the immunological knowledge of infection caused by Leishmania mexicana and, addresses the role of antibodies as a possible therapeutic strategy.</description><identifier>ISSN: 2049-632X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1093/femspd/ftaa060</identifier><identifier>PMID: 33016312</identifier><language>eng</language><publisher>OXFORD: Oxford University Press</publisher><subject>Animal diseases ; Animal models ; Antigens ; Cytokines ; Development and progression ; Drug therapy ; Host-parasite relationships ; Immune response ; Immune system ; Immunization ; Immunization (passive) ; Immunology ; Immunopathogenesis ; Infectious Diseases ; Leishmania mexicana ; Leishmaniasis ; Life Sciences & Biomedicine ; Microbiology ; Monoclonal antibodies ; Parasites ; Parasitological research ; Public health ; Science & Technology ; Vaccines</subject><ispartof>Pathogens and Disease, 2020-11, Vol.78 (8), p.1, Article 060</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of FEMS. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of FEMS.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000593394900005</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c424t-4a296e1b497376fd8b41dadd547e553d5217494b9f35dfb6dde1c3614cfb0a4e3</citedby><cites>FETCH-LOGICAL-c424t-4a296e1b497376fd8b41dadd547e553d5217494b9f35dfb6dde1c3614cfb0a4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1586,1606,27931,27932,28255</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/femspd/ftaa060$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33016312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez-Serrato, Mayra A</creatorcontrib><creatorcontrib>Salinas-Carmona, Mario C</creatorcontrib><creatorcontrib>Limón-Flores, Alberto Yairh</creatorcontrib><title>Immune response to Leishmania mexicana: the host–parasite relationship</title><title>Pathogens and Disease</title><addtitle>PATHOG DIS</addtitle><addtitle>Pathog Dis</addtitle><description>ABSTRACT
Leishmaniosis is currently considered a serious public health problem and it is listed as a neglected tropical disease by World Health Organization (WHO). Despite the efforts of the scientific community, it has not been possible to develop an effective vaccine. Current treatment consists of antimonials that is expensive and can cause adverse effects. It is essential to fully understand the immunopathogenesis of the disease to develop new strategies to prevent, treat and eradicate the disease. Studies on animal models have shown a new paradigm in the resolution or establishment of infection by Leishmania mexicana where a wide range of cytokines, antibodies and cells are involved. In recent years, the possibility of a new therapy with monoclonal antibodies has been considered, where isotype, specificity and concentration are critical for effective therapy. Would be better to create/generate a vaccine to induce host protection or produce passive immunization with engineering monoclonal antibodies to a defined antigen? This review provides an overview that includes the current known information on the immune response that are involved in the complex host–parasite relationship infection caused by L. mexicana.
This review describes the latest studies on the immunological knowledge of infection caused by Leishmania mexicana and, addresses the role of antibodies as a possible therapeutic strategy.</description><subject>Animal diseases</subject><subject>Animal models</subject><subject>Antigens</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Drug therapy</subject><subject>Host-parasite relationships</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Immunization (passive)</subject><subject>Immunology</subject><subject>Immunopathogenesis</subject><subject>Infectious Diseases</subject><subject>Leishmania mexicana</subject><subject>Leishmaniasis</subject><subject>Life Sciences & Biomedicine</subject><subject>Microbiology</subject><subject>Monoclonal antibodies</subject><subject>Parasites</subject><subject>Parasitological research</subject><subject>Public health</subject><subject>Science & Technology</subject><subject>Vaccines</subject><issn>2049-632X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkcFqFTEUhgex2NJ261IG3Chy22RyJjNxVy7VFi50o-BuyCQn3pRJMk4yVHe-Q9_QJzHXuVZxYxNIQvj-ww9fUTyn5IwSwc4Nujjqc5OkJJw8KY4qAmLFWfXp6V_vw-I0xluSV1vTtuHPikPGCOWMVkfF1bVzs8dywjgGH7FModygjVsnvZWlw69WSS_flmmL5TbE9OP7_SgnGW3ahQaZbI5t7XhSHBg5RDzd38fFx3eXH9ZXq83N--v1xWaloIK0AlkJjrQH0bCGG932QLXUuoYG65rpuqINCOiFYbU2PdcaqWKcgjI9kYDsuHi1zB2n8GXGmDpno8JhkB7DHLsKoOVQtQQy-vIf9DbMk8_tMtVQkg_gmTpbqM9ywM56E9IkVd4anVXBo7H5_4ILSglUAv4E1BRinNB042SdnL51lHQ7L93ipdt7yYEX-x5z71A_4L8tZODNAtxhH0xUFr3CByyLqwVjAsTOYZ3p9vH02qZfitZh9ilHXy_RMI__a_0TObK6QA</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Rodríguez-Serrato, Mayra A</creator><creator>Salinas-Carmona, Mario C</creator><creator>Limón-Flores, Alberto Yairh</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7T7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>Immune response to Leishmania mexicana: the host–parasite relationship</title><author>Rodríguez-Serrato, Mayra A ; Salinas-Carmona, Mario C ; Limón-Flores, Alberto Yairh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-4a296e1b497376fd8b41dadd547e553d5217494b9f35dfb6dde1c3614cfb0a4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal diseases</topic><topic>Animal models</topic><topic>Antigens</topic><topic>Cytokines</topic><topic>Development and progression</topic><topic>Drug therapy</topic><topic>Host-parasite relationships</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Immunization (passive)</topic><topic>Immunology</topic><topic>Immunopathogenesis</topic><topic>Infectious Diseases</topic><topic>Leishmania mexicana</topic><topic>Leishmaniasis</topic><topic>Life Sciences & Biomedicine</topic><topic>Microbiology</topic><topic>Monoclonal antibodies</topic><topic>Parasites</topic><topic>Parasitological research</topic><topic>Public health</topic><topic>Science & Technology</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Serrato, Mayra A</creatorcontrib><creatorcontrib>Salinas-Carmona, Mario C</creatorcontrib><creatorcontrib>Limón-Flores, Alberto Yairh</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pathogens and Disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Rodríguez-Serrato, Mayra A</au><au>Salinas-Carmona, Mario C</au><au>Limón-Flores, Alberto Yairh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune response to Leishmania mexicana: the host–parasite relationship</atitle><jtitle>Pathogens and Disease</jtitle><stitle>PATHOG DIS</stitle><addtitle>Pathog Dis</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>78</volume><issue>8</issue><spage>1</spage><pages>1-</pages><artnum>060</artnum><issn>2049-632X</issn><eissn>2049-632X</eissn><abstract>ABSTRACT
Leishmaniosis is currently considered a serious public health problem and it is listed as a neglected tropical disease by World Health Organization (WHO). Despite the efforts of the scientific community, it has not been possible to develop an effective vaccine. Current treatment consists of antimonials that is expensive and can cause adverse effects. It is essential to fully understand the immunopathogenesis of the disease to develop new strategies to prevent, treat and eradicate the disease. Studies on animal models have shown a new paradigm in the resolution or establishment of infection by Leishmania mexicana where a wide range of cytokines, antibodies and cells are involved. In recent years, the possibility of a new therapy with monoclonal antibodies has been considered, where isotype, specificity and concentration are critical for effective therapy. Would be better to create/generate a vaccine to induce host protection or produce passive immunization with engineering monoclonal antibodies to a defined antigen? This review provides an overview that includes the current known information on the immune response that are involved in the complex host–parasite relationship infection caused by L. mexicana.
This review describes the latest studies on the immunological knowledge of infection caused by Leishmania mexicana and, addresses the role of antibodies as a possible therapeutic strategy.</abstract><cop>OXFORD</cop><pub>Oxford University Press</pub><pmid>33016312</pmid><doi>10.1093/femspd/ftaa060</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 2049-632X |
| ispartof | Pathogens and Disease, 2020-11, Vol.78 (8), p.1, Article 060 |
| issn | 2049-632X 2049-632X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2448642804 |
| source | Access via Oxford University Press (Open Access Collection) |
| subjects | Animal diseases Animal models Antigens Cytokines Development and progression Drug therapy Host-parasite relationships Immune response Immune system Immunization Immunization (passive) Immunology Immunopathogenesis Infectious Diseases Leishmania mexicana Leishmaniasis Life Sciences & Biomedicine Microbiology Monoclonal antibodies Parasites Parasitological research Public health Science & Technology Vaccines |
| title | Immune response to Leishmania mexicana: the host–parasite relationship |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T07%3A21%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_TOX&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immune%20response%20to%20Leishmania%20mexicana:%20the%20host%E2%80%93parasite%20relationship&rft.jtitle=Pathogens%20and%20Disease&rft.au=Rodr%C3%ADguez-Serrato,%20Mayra%20A&rft.date=2020-11-01&rft.volume=78&rft.issue=8&rft.spage=1&rft.pages=1-&rft.artnum=060&rft.issn=2049-632X&rft.eissn=2049-632X&rft_id=info:doi/10.1093/femspd/ftaa060&rft_dat=%3Cgale_TOX%3EA691104294%3C/gale_TOX%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471024746&rft_id=info:pmid/33016312&rft_galeid=A691104294&rft_oup_id=10.1093/femspd/ftaa060&rfr_iscdi=true |