Effects of serial cervical or tail blood sampling on toxicity and toxicokinetic evaluation in rats

To assess the influences of blood sampling volumes or sites on toxicological and toxicokinetic (TK) evaluations, 4-week duration animal studies and a single-dose TK study of imipramine were conducted. In the toxicological evaluation, six-week-old Sprague-Dawley rats were divided into no blood and bl...

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Veröffentlicht in:	Journal of toxicological sciences 2020, Vol.45(10), pp.599-609
Hauptverfasser:	Hattori, Norimichi, Takumi, Asuka, Saito, Kosuke, Saito, Yoshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Blood levels Erythrocytes Evaluation Hemorrhage Imipramine Jugular vein Microsampling Oral administration Parameters Rats Rodents Sampling Sampling site Toxicity Toxicokinetic influence Toxicological influence Veins Veins & arteries
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