Methylglyoxal-Mediated Dopamine Depletion, Working Memory Deficit, and Depression-Like Behavior Are Prevented by a Dopamine/Noradrenaline Reuptake Inhibitor

Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis that has been associated to aging, Alzheimer’s disease, and inflammation. Cell culture studies reported that MGO could impair the glyoxalase, thioredoxin, and glutathione systems. Thus, we investigated the effe...

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Veröffentlicht in:	Molecular neurobiology 2021-02, Vol.58 (2), p.735-749
Hauptverfasser:	de Almeida, Gudrian Ricardo Lopes, Szczepanik, Jozimar Carlos, Selhorst, Ingrid, Schmitz, Ariana Ern, dos Santos, Bárbara, Cunha, Maurício Peña, Heinrich, Isabella Aparecida, de Paula, Gabriela Cristina, De Bem, Andreza Fabro, Leal, Rodrigo Bainy, Dafre, Alcir Luiz
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer's disease Animals Antidepressants Biomedical and Life Sciences Biomedicine Bupropion Bupropion - pharmacology Cell Biology Cell culture Cerebral cortex Depression - physiopathology Dopamine Dopamine - deficiency Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Female Glutathione Glutathione - metabolism Glycolysis Immobilization Inflammation Memory, Short-Term - drug effects Mental depression Mice Mice, Inbred BALB C Mice, Inbred C57BL Motor Activity - drug effects Neurobiology Neurodegenerative diseases Neurology Neurosciences Norepinephrine Norepinephrine - metabolism Phosphorylation Phosphorylation - drug effects Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Pyruvaldehyde Pyruvaldehyde - administration & dosage Pyruvaldehyde - adverse effects Serotonin Serotonin - metabolism Short term memory Spontaneous alternation Thioredoxin Toxicity Tyrosine 3-Monooxygenase - metabolism
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