The neuroprotective effect of osthole against chronic sleep deprivation (CSD)-induced memory impairment in rats

Sleep deprivation (SD) is a frequent health problem in modern society. Osthole (Ost), a natural coumarin, has antioxidant and neuroprotective properties. This study examined the functions of Ost in chronic sleep deprivation (CSD)-induced memory deficits in rats. The CSD rat model was constructed by...

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Veröffentlicht in:	Life sciences (1973) 2020-12, Vol.263, p.118524-118524, Article 118524
Hauptverfasser:	Tang, Hanqing, Li, Keming, Dou, Xibin, Zhao, Yufeng, Huang, Chunchuan, Shu, Fangyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Behavior, Animal - drug effects Behavioral tests Calcium Channel Blockers - pharmacology Chronic sleep deprivation Cognitive ability Coumarin Coumarins - pharmacology Disease Models, Animal Field tests Hippocampal plasticity Hippocampus In vivo methods and tests Male Memory Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - metabolism Memory Disorders - pathology Modafinil Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroplasticity Neuroprotection Neuroprotective Agents - pharmacology Object recognition Open-field behavior Osthole Oxidative Stress Pattern recognition Pyramidal cells Rats Rats, Wistar Sleep deprivation Sleep Deprivation - complications
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