Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Amyloidosis Status
The aim of this study is to characterize the pattern and the severity of coronary artery lesions in cardiac amyloidosis. We retrospectively compared patients with heart failure who tested positive (i.e., biopsy or gene tests – HF/CA+) against those who tested negative (HF/CA−) for cardiac amyloidosi...
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| Veröffentlicht in: | Cardiovascular revascularization medicine 2021-06, Vol.27, p.31-35 |
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| creator | Beyene, Solomon S. Yacob, Omar Melaku, Gebremedhin D. Hideo-Kajita, Alexandre Kuku, Kayode O. Brathwaite, Echo Wilson, Vanessa Dan, Kazuhiro Kadakkal, Ajay Sheikh, Farooq Mohammed, Selma Garcia-Garcia, Hector M. |
| description | The aim of this study is to characterize the pattern and the severity of coronary artery lesions in cardiac amyloidosis.
We retrospectively compared patients with heart failure who tested positive (i.e., biopsy or gene tests – HF/CA+) against those who tested negative (HF/CA−) for cardiac amyloidosis. Groups were compared demographically and angiographically for qualitative and quantitative variables to determine patterns of involvement in the major epicardial coronary vessels.
The study included 110 heart failure patients, of whom 55 patients (88 lesions) were in the HF/CA+ group, and 55 patients (66 lesions) were HF/CA−. Despite the advanced age of HF/CA+ patients (74.5 ± 11.0 years vs. 54.1 ± 15.0 years; p = 0.05), no severe calcification was found in the HF/CA+ group (0.0% vs. 4.5%; p = 0.018). The HF/CA+ group also had fewer ostial lesions (3.4% vs. 15.1%; p = 0.0095) and a higher, albeit not significant, Thrombolysis in Myocardial Infarction frame count (30.4 ± 12.6 vs. 26.6 ± 11 frames; p = 0.06). In the HF/CA+ group, men had a significant number of tandem lesions compared to women (14.5% vs 0.0%, p = 0.02).
Overall, heart failure patients with cardiac amyloidosis were older but were found to have less calcified lesions, less ostial involvement, and a reduced anterograde coronary blood flow. This is the first report examining coronary lesions in heart failure patients with cardiac amyloidosis.
•Heart failure patients with cardiac amyloidosis had fewer coronary lesions than those without cardiac amyloidosis•Men with cardiac amyloidosis and heart failure had a greater number of tandem lesions on coronary angiography than women•Older African American men were the predominant demographic in heart failure with cardiac amyloidosis |
| doi_str_mv | 10.1016/j.carrev.2020.09.026 |
| format | Article |
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We retrospectively compared patients with heart failure who tested positive (i.e., biopsy or gene tests – HF/CA+) against those who tested negative (HF/CA−) for cardiac amyloidosis. Groups were compared demographically and angiographically for qualitative and quantitative variables to determine patterns of involvement in the major epicardial coronary vessels.
The study included 110 heart failure patients, of whom 55 patients (88 lesions) were in the HF/CA+ group, and 55 patients (66 lesions) were HF/CA−. Despite the advanced age of HF/CA+ patients (74.5 ± 11.0 years vs. 54.1 ± 15.0 years; p = 0.05), no severe calcification was found in the HF/CA+ group (0.0% vs. 4.5%; p = 0.018). The HF/CA+ group also had fewer ostial lesions (3.4% vs. 15.1%; p = 0.0095) and a higher, albeit not significant, Thrombolysis in Myocardial Infarction frame count (30.4 ± 12.6 vs. 26.6 ± 11 frames; p = 0.06). In the HF/CA+ group, men had a significant number of tandem lesions compared to women (14.5% vs 0.0%, p = 0.02).
Overall, heart failure patients with cardiac amyloidosis were older but were found to have less calcified lesions, less ostial involvement, and a reduced anterograde coronary blood flow. This is the first report examining coronary lesions in heart failure patients with cardiac amyloidosis.
•Heart failure patients with cardiac amyloidosis had fewer coronary lesions than those without cardiac amyloidosis•Men with cardiac amyloidosis and heart failure had a greater number of tandem lesions on coronary angiography than women•Older African American men were the predominant demographic in heart failure with cardiac amyloidosis</description><identifier>ISSN: 1553-8389</identifier><identifier>EISSN: 1878-0938</identifier><identifier>DOI: 10.1016/j.carrev.2020.09.026</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Cardiac amyloidosis ; Coronary angiography ; Heart failure</subject><ispartof>Cardiovascular revascularization medicine, 2021-06, Vol.27, p.31-35</ispartof><rights>2020 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-3d44c216e8f24d2cc9e47c532c5de2a76d9fd5e22144f050b76cc2d4c3a062253</citedby><cites>FETCH-LOGICAL-c339t-3d44c216e8f24d2cc9e47c532c5de2a76d9fd5e22144f050b76cc2d4c3a062253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1553838920305753$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Beyene, Solomon S.</creatorcontrib><creatorcontrib>Yacob, Omar</creatorcontrib><creatorcontrib>Melaku, Gebremedhin D.</creatorcontrib><creatorcontrib>Hideo-Kajita, Alexandre</creatorcontrib><creatorcontrib>Kuku, Kayode O.</creatorcontrib><creatorcontrib>Brathwaite, Echo</creatorcontrib><creatorcontrib>Wilson, Vanessa</creatorcontrib><creatorcontrib>Dan, Kazuhiro</creatorcontrib><creatorcontrib>Kadakkal, Ajay</creatorcontrib><creatorcontrib>Sheikh, Farooq</creatorcontrib><creatorcontrib>Mohammed, Selma</creatorcontrib><creatorcontrib>Garcia-Garcia, Hector M.</creatorcontrib><title>Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Amyloidosis Status</title><title>Cardiovascular revascularization medicine</title><description>The aim of this study is to characterize the pattern and the severity of coronary artery lesions in cardiac amyloidosis.
We retrospectively compared patients with heart failure who tested positive (i.e., biopsy or gene tests – HF/CA+) against those who tested negative (HF/CA−) for cardiac amyloidosis. Groups were compared demographically and angiographically for qualitative and quantitative variables to determine patterns of involvement in the major epicardial coronary vessels.
The study included 110 heart failure patients, of whom 55 patients (88 lesions) were in the HF/CA+ group, and 55 patients (66 lesions) were HF/CA−. Despite the advanced age of HF/CA+ patients (74.5 ± 11.0 years vs. 54.1 ± 15.0 years; p = 0.05), no severe calcification was found in the HF/CA+ group (0.0% vs. 4.5%; p = 0.018). The HF/CA+ group also had fewer ostial lesions (3.4% vs. 15.1%; p = 0.0095) and a higher, albeit not significant, Thrombolysis in Myocardial Infarction frame count (30.4 ± 12.6 vs. 26.6 ± 11 frames; p = 0.06). In the HF/CA+ group, men had a significant number of tandem lesions compared to women (14.5% vs 0.0%, p = 0.02).
Overall, heart failure patients with cardiac amyloidosis were older but were found to have less calcified lesions, less ostial involvement, and a reduced anterograde coronary blood flow. This is the first report examining coronary lesions in heart failure patients with cardiac amyloidosis.
•Heart failure patients with cardiac amyloidosis had fewer coronary lesions than those without cardiac amyloidosis•Men with cardiac amyloidosis and heart failure had a greater number of tandem lesions on coronary angiography than women•Older African American men were the predominant demographic in heart failure with cardiac amyloidosis</description><subject>Cardiac amyloidosis</subject><subject>Coronary angiography</subject><subject>Heart failure</subject><issn>1553-8389</issn><issn>1878-0938</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LxDAUxIsouK5-Aw85emlNk_TfRViq6woLCioeQzZ5xSxts-ZlF_rtbalnT294zAzML4puU5qkNM3v94lW3sMpYZTRhFYJZflZtEjLooxpxcvzUWcZj0teVpfRFeKeUl6wvFhEfe26g_IWXU9cQ95UCOB7nHTtvOuVH8jKj7-BPFoEhUBsP9ks9AHJlw3fZAPKB7JWtj16ILuB1MobqzRZdUPrrHFokbwHFY54HV00qkW4-bvL6HP99FFv4u3r80u92saa8yrE3AihWZpD2TBhmNYViEJnnOnMAFNFbqrGZMBYKkRDM7orcq2ZEZormjOW8WV0N_cevPs5AgbZWdTQtqoHd0TJhChFylk2WcVs1d4hemjkwdtu3C1TKie8ci9nvHLCK2klR7xj7GGOwTjjZMFL1CMTDcZ60EEaZ_8v-AW_c4Zw</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Beyene, Solomon S.</creator><creator>Yacob, Omar</creator><creator>Melaku, Gebremedhin D.</creator><creator>Hideo-Kajita, Alexandre</creator><creator>Kuku, Kayode O.</creator><creator>Brathwaite, Echo</creator><creator>Wilson, Vanessa</creator><creator>Dan, Kazuhiro</creator><creator>Kadakkal, Ajay</creator><creator>Sheikh, Farooq</creator><creator>Mohammed, Selma</creator><creator>Garcia-Garcia, Hector M.</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Amyloidosis Status</title><author>Beyene, Solomon S. ; Yacob, Omar ; Melaku, Gebremedhin D. ; Hideo-Kajita, Alexandre ; Kuku, Kayode O. ; Brathwaite, Echo ; Wilson, Vanessa ; Dan, Kazuhiro ; Kadakkal, Ajay ; Sheikh, Farooq ; Mohammed, Selma ; Garcia-Garcia, Hector M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-3d44c216e8f24d2cc9e47c532c5de2a76d9fd5e22144f050b76cc2d4c3a062253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiac amyloidosis</topic><topic>Coronary angiography</topic><topic>Heart failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beyene, Solomon S.</creatorcontrib><creatorcontrib>Yacob, Omar</creatorcontrib><creatorcontrib>Melaku, Gebremedhin D.</creatorcontrib><creatorcontrib>Hideo-Kajita, Alexandre</creatorcontrib><creatorcontrib>Kuku, Kayode O.</creatorcontrib><creatorcontrib>Brathwaite, Echo</creatorcontrib><creatorcontrib>Wilson, Vanessa</creatorcontrib><creatorcontrib>Dan, Kazuhiro</creatorcontrib><creatorcontrib>Kadakkal, Ajay</creatorcontrib><creatorcontrib>Sheikh, Farooq</creatorcontrib><creatorcontrib>Mohammed, Selma</creatorcontrib><creatorcontrib>Garcia-Garcia, Hector M.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular revascularization medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beyene, Solomon S.</au><au>Yacob, Omar</au><au>Melaku, Gebremedhin D.</au><au>Hideo-Kajita, Alexandre</au><au>Kuku, Kayode O.</au><au>Brathwaite, Echo</au><au>Wilson, Vanessa</au><au>Dan, Kazuhiro</au><au>Kadakkal, Ajay</au><au>Sheikh, Farooq</au><au>Mohammed, Selma</au><au>Garcia-Garcia, Hector M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Amyloidosis Status</atitle><jtitle>Cardiovascular revascularization medicine</jtitle><date>2021-06</date><risdate>2021</risdate><volume>27</volume><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>1553-8389</issn><eissn>1878-0938</eissn><abstract>The aim of this study is to characterize the pattern and the severity of coronary artery lesions in cardiac amyloidosis.
We retrospectively compared patients with heart failure who tested positive (i.e., biopsy or gene tests – HF/CA+) against those who tested negative (HF/CA−) for cardiac amyloidosis. Groups were compared demographically and angiographically for qualitative and quantitative variables to determine patterns of involvement in the major epicardial coronary vessels.
The study included 110 heart failure patients, of whom 55 patients (88 lesions) were in the HF/CA+ group, and 55 patients (66 lesions) were HF/CA−. Despite the advanced age of HF/CA+ patients (74.5 ± 11.0 years vs. 54.1 ± 15.0 years; p = 0.05), no severe calcification was found in the HF/CA+ group (0.0% vs. 4.5%; p = 0.018). The HF/CA+ group also had fewer ostial lesions (3.4% vs. 15.1%; p = 0.0095) and a higher, albeit not significant, Thrombolysis in Myocardial Infarction frame count (30.4 ± 12.6 vs. 26.6 ± 11 frames; p = 0.06). In the HF/CA+ group, men had a significant number of tandem lesions compared to women (14.5% vs 0.0%, p = 0.02).
Overall, heart failure patients with cardiac amyloidosis were older but were found to have less calcified lesions, less ostial involvement, and a reduced anterograde coronary blood flow. This is the first report examining coronary lesions in heart failure patients with cardiac amyloidosis.
•Heart failure patients with cardiac amyloidosis had fewer coronary lesions than those without cardiac amyloidosis•Men with cardiac amyloidosis and heart failure had a greater number of tandem lesions on coronary angiography than women•Older African American men were the predominant demographic in heart failure with cardiac amyloidosis</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.carrev.2020.09.026</doi><tpages>5</tpages></addata></record> |
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| subjects | Cardiac amyloidosis Coronary angiography Heart failure |
| title | Comparison of Patterns of Coronary Artery Disease in Patients With Heart Failure by Cardiac Amyloidosis Status |
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