Chronic sigma-1 receptor activation ameliorates ventricular remodeling and decreases susceptibility to ventricular arrhythmias after myocardial infarction in rats

The present study aimed to assess the effect of sigma-1 receptor (S1R) stimulation on ventricular remodeling and susceptibility to ventricular arrhythmias (VAs) after myocardial infarction (MI) in rats. Wild-type male rats were placed into one of the following four treatment groups. For four weeks,...

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Veröffentlicht in:	European journal of pharmacology 2020-12, Vol.889, p.173614-173614, Article 173614
Hauptverfasser:	Fo, Yuhong, Zhang, Cui, Chen, Xiuhuan, Liu, Xin, Ye, Tianxin, Guo, Yan, Qu, Chuan, Shi, Shaobo, Yang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Administration Schedule Fluvoxamine Fluvoxamine - administration & dosage Male Myocardial infarction Myocardial Infarction - complications Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Rats Rats, Sprague-Dawley Receptors, sigma - agonists Receptors, sigma - metabolism Sigma-1 Receptor Ventricular arrhythmia Ventricular Fibrillation - etiology Ventricular Fibrillation - metabolism Ventricular Fibrillation - prevention & control Ventricular remodeling Ventricular Remodeling - drug effects Ventricular Remodeling - physiology
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