Transcription factor Ets-2 regulates the expression of key lymphotropic factors

Transcription factor Ets-2 downregulates the expression of cytokine genes and HIV-1 in resting T-cells. Herein, we studied whether Ets-2 regulates the expression of lymphotropic factors (LFs) NFAT2, NF-κΒ/p65, c-Jun, c-Fos, which regulate the activation/differentiation of T-cells, and kinase CDK10,...

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Veröffentlicht in:	Molecular biology reports 2020-10, Vol.47 (10), p.7871-7881
Hauptverfasser:	Davoulou, Panagiota, Aggeletopoulou, Ioanna, Panagoulias, Ioannis, Georgakopoulos, Tassos, Mouzaki, Athanasia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Apoptosis Binding sites Biomedical and Life Sciences c-Fos protein c-Jun protein Cell activation Cell culture Cell Differentiation Cell lines Cell signaling Cytokines ETS protein Fos protein Gene Expression Regulation Histology HIV Human immunodeficiency virus Humans Immunoblotting Jurkat Cells Kinases Latency Life Sciences Lymphocyte Activation Lymphocytes T Mitogens Morphology NF-AT protein Original Article Promoters Proteins Proto-Oncogene Protein c-ets-2 - genetics Proto-Oncogene Protein c-ets-2 - metabolism Synaptotagmin T-Lymphocytes - metabolism Transcription activation Transcription factors
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