Changes in physical activity and risk of fracture: a Korean nationwide population-based cohort study
Physical activity (PA) is one of the most important modifiable factors associated with fracture risk. However, the association between interval changes in PA and the risk of fracture remains unknown. We investigated the risk of fracture development according to interval changes in PA in middle aged...
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| Veröffentlicht in: | Scientific reports 2020-10, Vol.10 (1), p.16266-16266, Article 16266 |
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| description | Physical activity (PA) is one of the most important modifiable factors associated with fracture risk. However, the association between interval changes in PA and the risk of fracture remains unknown. We investigated the risk of fracture development according to interval changes in PA in middle aged and older individuals. In this nationwide cohort study of adults aged ≥ 40 years, more than 4.9 million individuals without fractures within the last year who underwent two consecutive national health screenings in Korea from 2009 to 2012 were identified. The risk of fracture between 2013 and 2016 according to interval changes in regular PA was prospectively analyzed. Compared to individuals with a continuous lack of PA, those with a decrease in PA (0.41/1000 person-years (PY) decrease in incidence rate (IR); adjusted hazard ratio (aHR) 0.975; 95% confidence interval (CI) 0.964–0.987), increase in PA (1.8/1000 PY decrease in IR; aHR 0.948; 95% CI 0.937–0.959), and continuous PA (3.58/1000 PY decrease in IR; aHR 0.888; 95% CI 0.875–0.901) had a significantly reduced risk of fracture. Interval changes in regular PA were associated with risk of fracture. Individuals who engaged in continuous regular PA exhibited the maximum protective benefit against fracture. |
| doi_str_mv | 10.1038/s41598-020-73495-1 |
| format | Article |
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However, the association between interval changes in PA and the risk of fracture remains unknown. We investigated the risk of fracture development according to interval changes in PA in middle aged and older individuals. In this nationwide cohort study of adults aged ≥ 40 years, more than 4.9 million individuals without fractures within the last year who underwent two consecutive national health screenings in Korea from 2009 to 2012 were identified. The risk of fracture between 2013 and 2016 according to interval changes in regular PA was prospectively analyzed. Compared to individuals with a continuous lack of PA, those with a decrease in PA (0.41/1000 person-years (PY) decrease in incidence rate (IR); adjusted hazard ratio (aHR) 0.975; 95% confidence interval (CI) 0.964–0.987), increase in PA (1.8/1000 PY decrease in IR; aHR 0.948; 95% CI 0.937–0.959), and continuous PA (3.58/1000 PY decrease in IR; aHR 0.888; 95% CI 0.875–0.901) had a significantly reduced risk of fracture. Interval changes in regular PA were associated with risk of fracture. Individuals who engaged in continuous regular PA exhibited the maximum protective benefit against fracture.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-73495-1</identifier><identifier>PMID: 33004986</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308 ; 692/499 ; 692/700 ; Adult ; Aged ; Alcohol ; Ambulatory care ; Blood pressure ; Cohort analysis ; Exercise ; Female ; Fractures ; Fractures, Bone - epidemiology ; Fractures, Bone - etiology ; Health insurance ; Hospitals ; Humanities and Social Sciences ; Humans ; Male ; Middle age ; Middle Aged ; multidisciplinary ; Multidisciplinary Sciences ; Physical activity ; Physical fitness ; Population ; Population studies ; Population-based studies ; Prospective Studies ; Questionnaires ; Republic of Korea - epidemiology ; Risk Factors ; Risk reduction ; Science ; Science & Technology ; Science & Technology - Other Topics ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.16266-16266, Article 16266</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>18</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000577143400029</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c522t-d1cca675b951cf35988edff24c3761d02612ac53ad528737fa1044fe7b0408583</citedby><cites>FETCH-LOGICAL-c522t-d1cca675b951cf35988edff24c3761d02612ac53ad528737fa1044fe7b0408583</cites><orcidid>0000-0001-6548-4921 ; 0000-0002-9709-3332</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531000/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531000/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2115,27928,27929,41124,42193,51580,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33004986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Sangsoo</creatorcontrib><creatorcontrib>Jang, Hae-Dong</creatorcontrib><creatorcontrib>Choi, Sungwoo</creatorcontrib><creatorcontrib>Kim, Gi Deok</creatorcontrib><creatorcontrib>Han, Kyungdo</creatorcontrib><creatorcontrib>Lim, Hyunwoong</creatorcontrib><creatorcontrib>Koo, Bongmo</creatorcontrib><creatorcontrib>Min, Kyung Dae</creatorcontrib><creatorcontrib>Hong, Jae-Young</creatorcontrib><title>Changes in physical activity and risk of fracture: a Korean nationwide population-based cohort study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>SCI REP-UK</addtitle><addtitle>Sci Rep</addtitle><description>Physical activity (PA) is one of the most important modifiable factors associated with fracture risk. However, the association between interval changes in PA and the risk of fracture remains unknown. We investigated the risk of fracture development according to interval changes in PA in middle aged and older individuals. In this nationwide cohort study of adults aged ≥ 40 years, more than 4.9 million individuals without fractures within the last year who underwent two consecutive national health screenings in Korea from 2009 to 2012 were identified. The risk of fracture between 2013 and 2016 according to interval changes in regular PA was prospectively analyzed. Compared to individuals with a continuous lack of PA, those with a decrease in PA (0.41/1000 person-years (PY) decrease in incidence rate (IR); adjusted hazard ratio (aHR) 0.975; 95% confidence interval (CI) 0.964–0.987), increase in PA (1.8/1000 PY decrease in IR; aHR 0.948; 95% CI 0.937–0.959), and continuous PA (3.58/1000 PY decrease in IR; aHR 0.888; 95% CI 0.875–0.901) had a significantly reduced risk of fracture. Interval changes in regular PA were associated with risk of fracture. Individuals who engaged in continuous regular PA exhibited the maximum protective benefit against fracture.</description><subject>692/308</subject><subject>692/499</subject><subject>692/700</subject><subject>Adult</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Ambulatory care</subject><subject>Blood pressure</subject><subject>Cohort analysis</subject><subject>Exercise</subject><subject>Female</subject><subject>Fractures</subject><subject>Fractures, Bone - epidemiology</subject><subject>Fractures, Bone - etiology</subject><subject>Health insurance</subject><subject>Hospitals</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multidisciplinary Sciences</subject><subject>Physical activity</subject><subject>Physical fitness</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><subject>Republic of Korea - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Sangsoo</au><au>Jang, Hae-Dong</au><au>Choi, Sungwoo</au><au>Kim, Gi Deok</au><au>Han, Kyungdo</au><au>Lim, Hyunwoong</au><au>Koo, Bongmo</au><au>Min, Kyung Dae</au><au>Hong, Jae-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in physical activity and risk of fracture: a Korean nationwide population-based cohort study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>16266</spage><epage>16266</epage><pages>16266-16266</pages><artnum>16266</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Physical activity (PA) is one of the most important modifiable factors associated with fracture risk. However, the association between interval changes in PA and the risk of fracture remains unknown. We investigated the risk of fracture development according to interval changes in PA in middle aged and older individuals. In this nationwide cohort study of adults aged ≥ 40 years, more than 4.9 million individuals without fractures within the last year who underwent two consecutive national health screenings in Korea from 2009 to 2012 were identified. The risk of fracture between 2013 and 2016 according to interval changes in regular PA was prospectively analyzed. Compared to individuals with a continuous lack of PA, those with a decrease in PA (0.41/1000 person-years (PY) decrease in incidence rate (IR); adjusted hazard ratio (aHR) 0.975; 95% confidence interval (CI) 0.964–0.987), increase in PA (1.8/1000 PY decrease in IR; aHR 0.948; 95% CI 0.937–0.959), and continuous PA (3.58/1000 PY decrease in IR; aHR 0.888; 95% CI 0.875–0.901) had a significantly reduced risk of fracture. Interval changes in regular PA were associated with risk of fracture. Individuals who engaged in continuous regular PA exhibited the maximum protective benefit against fracture.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33004986</pmid><doi>10.1038/s41598-020-73495-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6548-4921</orcidid><orcidid>https://orcid.org/0000-0002-9709-3332</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308 692/499 692/700 Adult Aged Alcohol Ambulatory care Blood pressure Cohort analysis Exercise Female Fractures Fractures, Bone - epidemiology Fractures, Bone - etiology Health insurance Hospitals Humanities and Social Sciences Humans Male Middle age Middle Aged multidisciplinary Multidisciplinary Sciences Physical activity Physical fitness Population Population studies Population-based studies Prospective Studies Questionnaires Republic of Korea - epidemiology Risk Factors Risk reduction Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) |
| title | Changes in physical activity and risk of fracture: a Korean nationwide population-based cohort study |
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