Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that causes debilitating musculoskeletal disease. CHIKV displays broad cell, tissue, and species tropism, which may correlate with the attachment factors and entry receptors used by the virus. Cell surface glycosaminoglycans (GAGs) have been i...

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Veröffentlicht in:	Journal of virology 2020-11, Vol.94 (24), Article 01500
Hauptverfasser:	McAllister, Nicole, Liu, Yan, Silva, Lisete M., Lentscher, Anthony J., Chai, Wengang, Wu, Nian, Griswold, Kira A., Raghunathan, Krishnan, Vang, Lo, Alexander, Jeff, Warfield, Kelly L., Diamond, Michael S., Feizi, Ten, Silva, Laurie A., Dermody, Terence S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Cell Line Chikungunya Fever - virology Chikungunya virus - physiology Glucuronosyltransferase - genetics Glycosaminoglycans - metabolism Heparin - metabolism Heparitin Sulfate - metabolism Humans Life Sciences & Biomedicine Polysaccharides - metabolism Science & Technology Spotlight Viral Tropism Virology Virus Attachment Virus-Cell Interactions
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