Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging
Purpose Migraine with aura (MwA) in the emergency setting is common and sometimes difficult to distinguish from mimicking conditions. Susceptibility weighted imaging (SWI), a magnet resonance (MR) technique is sensitive to deoxygenated hemoglobin in cerebral veins and depicts these according to thei...
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| Veröffentlicht in: | Clinical neuroradiology (Munich) 2021-09, Vol.31 (3), p.581-588 |
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| creator | Kellner-Weldon, Frauke Jossen, Marina Breiding, Philipe S. Grunder, Lorenz Schankin, Christoph Scutelnic, Adrian Fischer, Urs Muri, Raphaela Pastore-Wapp, Manuela Wiest, Roland El-Koussy, Marwan |
| description | Purpose
Migraine with aura (MwA) in the emergency setting is common and sometimes difficult to distinguish from mimicking conditions. Susceptibility weighted imaging (SWI), a magnet resonance (MR) technique is sensitive to deoxygenated hemoglobin in cerebral veins and depicts these according to their level of oxygenation. Our study aimed at evaluating the frequency of regions of prominent focal veins (PFV) on SWI in the acute phase.
Methods
Between 2011 and 2018 we evaluated symptoms and MR imaging of adult patients with acute MwA attacks ( |
| doi_str_mv | 10.1007/s00062-020-00962-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2447841056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A718263867</galeid><sourcerecordid>A718263867</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-c788f110c7081e74028c20523bc11ba8cf9d21c5601eefc6bb19a482541449b53</originalsourceid><addsrcrecordid>eNp9kUFP3DAQhS3UChDlD3BAkbj0Ehg7TuwcV6gUJKCHFnG0HO8kGCXOYsdU_Hu8ZAGBqsoHj-zvPc3MI-SAwjEFECcBACqWA4McoE6V2CK7VFZ1TjkXX97qot4h-yHcJxwKWZel2CY7RQFAGZO7RF8MurOuy64x-vFRBxN77bMbZ8a46tcf1mULEyfMrmzntXWY_bXTXbaIXs_V7xgMribb2N5OT9kt2u5uwmW2cf5Gvra6D7i_uffIzdmPP6fn-eWvnxeni8vccM6m3AgpW0rBCJAUBQcmDYOSFY2htNHStPWSUVNWQBFbUzUNrTWXrORp3ropiz3yffZd-fEhYpjUYFNjfa8djjEoltYiOYWySujRJ_R-jN6l7hQrRZU2UxX8nep0j8q6dpy8NmtTtRBUJkZWIlHH_6DSWeJgzeiwten9g4DNAuPHEDy2auXtoP2ToqDW0ao5WpWiVS_RqrXocNNxbAZcvkleg0xAMQMhfbkO_ftI_7F9BqKhq8I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2576122634</pqid></control><display><type>article</type><title>Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kellner-Weldon, Frauke ; Jossen, Marina ; Breiding, Philipe S. ; Grunder, Lorenz ; Schankin, Christoph ; Scutelnic, Adrian ; Fischer, Urs ; Muri, Raphaela ; Pastore-Wapp, Manuela ; Wiest, Roland ; El-Koussy, Marwan</creator><creatorcontrib>Kellner-Weldon, Frauke ; Jossen, Marina ; Breiding, Philipe S. ; Grunder, Lorenz ; Schankin, Christoph ; Scutelnic, Adrian ; Fischer, Urs ; Muri, Raphaela ; Pastore-Wapp, Manuela ; Wiest, Roland ; El-Koussy, Marwan</creatorcontrib><description>Purpose
Migraine with aura (MwA) in the emergency setting is common and sometimes difficult to distinguish from mimicking conditions. Susceptibility weighted imaging (SWI), a magnet resonance (MR) technique is sensitive to deoxygenated hemoglobin in cerebral veins and depicts these according to their level of oxygenation. Our study aimed at evaluating the frequency of regions of prominent focal veins (PFV) on SWI in the acute phase.
Methods
Between 2011 and 2018 we evaluated symptoms and MR imaging of adult patients with acute MwA attacks (< 5 days after onset of symptoms). Abnormal imaging was visually scored in 12 ROIs on both hemispheres distributed on 3 slices. The score ranged from 0 to 3.
Results
In all, 638 patients (436 female) mean age 37.39 years (18–89 ± 14.13) were included. Susceptibility weighted imaging was abnormal in 18.8% of patients. The inferior and posterior medial temporal lobe and the occipital lobe were most often affected. Susceptibility weighted imaging was more likely abnormal when MR was performed within 24 hours with an average around 5 hours after symptom onset. The side of aura symptoms and hemispheric imaging alteration in patients with abnormal SWI was highly significant (
p
< 0.001).
Conclusion
In the acute episode of MwA, SWI imaging can show a combination of increased deoxygenation. The results may indicate linking PFV to MwA.</description><identifier>ISSN: 1869-1439</identifier><identifier>EISSN: 1869-1447</identifier><identifier>DOI: 10.1007/s00062-020-00962-7</identifier><identifier>PMID: 33001228</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asymmetry ; Cerebral Veins ; Epilepsy ; Female ; Hemoglobin ; Humans ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Migraine ; Migraine with Aura - diagnostic imaging ; Neurology ; Neuroradiology ; Neurosurgery ; Original Article ; Patients ; Pediatrics ; Stroke ; Symmetry ; Veins & arteries ; Young Adult</subject><ispartof>Clinical neuroradiology (Munich), 2021-09, Vol.31 (3), p.581-588</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>2020. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-c788f110c7081e74028c20523bc11ba8cf9d21c5601eefc6bb19a482541449b53</citedby><cites>FETCH-LOGICAL-c442t-c788f110c7081e74028c20523bc11ba8cf9d21c5601eefc6bb19a482541449b53</cites><orcidid>0000-0002-6019-0147</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00062-020-00962-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00062-020-00962-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33001228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kellner-Weldon, Frauke</creatorcontrib><creatorcontrib>Jossen, Marina</creatorcontrib><creatorcontrib>Breiding, Philipe S.</creatorcontrib><creatorcontrib>Grunder, Lorenz</creatorcontrib><creatorcontrib>Schankin, Christoph</creatorcontrib><creatorcontrib>Scutelnic, Adrian</creatorcontrib><creatorcontrib>Fischer, Urs</creatorcontrib><creatorcontrib>Muri, Raphaela</creatorcontrib><creatorcontrib>Pastore-Wapp, Manuela</creatorcontrib><creatorcontrib>Wiest, Roland</creatorcontrib><creatorcontrib>El-Koussy, Marwan</creatorcontrib><title>Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging</title><title>Clinical neuroradiology (Munich)</title><addtitle>Clin Neuroradiol</addtitle><addtitle>Clin Neuroradiol</addtitle><description>Purpose
Migraine with aura (MwA) in the emergency setting is common and sometimes difficult to distinguish from mimicking conditions. Susceptibility weighted imaging (SWI), a magnet resonance (MR) technique is sensitive to deoxygenated hemoglobin in cerebral veins and depicts these according to their level of oxygenation. Our study aimed at evaluating the frequency of regions of prominent focal veins (PFV) on SWI in the acute phase.
Methods
Between 2011 and 2018 we evaluated symptoms and MR imaging of adult patients with acute MwA attacks (< 5 days after onset of symptoms). Abnormal imaging was visually scored in 12 ROIs on both hemispheres distributed on 3 slices. The score ranged from 0 to 3.
Results
In all, 638 patients (436 female) mean age 37.39 years (18–89 ± 14.13) were included. Susceptibility weighted imaging was abnormal in 18.8% of patients. The inferior and posterior medial temporal lobe and the occipital lobe were most often affected. Susceptibility weighted imaging was more likely abnormal when MR was performed within 24 hours with an average around 5 hours after symptom onset. The side of aura symptoms and hemispheric imaging alteration in patients with abnormal SWI was highly significant (
p
< 0.001).
Conclusion
In the acute episode of MwA, SWI imaging can show a combination of increased deoxygenation. The results may indicate linking PFV to MwA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asymmetry</subject><subject>Cerebral Veins</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Migraine</subject><subject>Migraine with Aura - diagnostic imaging</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Stroke</subject><subject>Symmetry</subject><subject>Veins & arteries</subject><subject>Young Adult</subject><issn>1869-1439</issn><issn>1869-1447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUFP3DAQhS3UChDlD3BAkbj0Ehg7TuwcV6gUJKCHFnG0HO8kGCXOYsdU_Hu8ZAGBqsoHj-zvPc3MI-SAwjEFECcBACqWA4McoE6V2CK7VFZ1TjkXX97qot4h-yHcJxwKWZel2CY7RQFAGZO7RF8MurOuy64x-vFRBxN77bMbZ8a46tcf1mULEyfMrmzntXWY_bXTXbaIXs_V7xgMribb2N5OT9kt2u5uwmW2cf5Gvra6D7i_uffIzdmPP6fn-eWvnxeni8vccM6m3AgpW0rBCJAUBQcmDYOSFY2htNHStPWSUVNWQBFbUzUNrTWXrORp3ropiz3yffZd-fEhYpjUYFNjfa8djjEoltYiOYWySujRJ_R-jN6l7hQrRZU2UxX8nep0j8q6dpy8NmtTtRBUJkZWIlHH_6DSWeJgzeiwten9g4DNAuPHEDy2auXtoP2ToqDW0ao5WpWiVS_RqrXocNNxbAZcvkleg0xAMQMhfbkO_ftI_7F9BqKhq8I</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Kellner-Weldon, Frauke</creator><creator>Jossen, Marina</creator><creator>Breiding, Philipe S.</creator><creator>Grunder, Lorenz</creator><creator>Schankin, Christoph</creator><creator>Scutelnic, Adrian</creator><creator>Fischer, Urs</creator><creator>Muri, Raphaela</creator><creator>Pastore-Wapp, Manuela</creator><creator>Wiest, Roland</creator><creator>El-Koussy, Marwan</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6019-0147</orcidid></search><sort><creationdate>20210901</creationdate><title>Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging</title><author>Kellner-Weldon, Frauke ; Jossen, Marina ; Breiding, Philipe S. ; Grunder, Lorenz ; Schankin, Christoph ; Scutelnic, Adrian ; Fischer, Urs ; Muri, Raphaela ; Pastore-Wapp, Manuela ; Wiest, Roland ; El-Koussy, Marwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-c788f110c7081e74028c20523bc11ba8cf9d21c5601eefc6bb19a482541449b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asymmetry</topic><topic>Cerebral Veins</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Migraine</topic><topic>Migraine with Aura - diagnostic imaging</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Stroke</topic><topic>Symmetry</topic><topic>Veins & arteries</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kellner-Weldon, Frauke</creatorcontrib><creatorcontrib>Jossen, Marina</creatorcontrib><creatorcontrib>Breiding, Philipe S.</creatorcontrib><creatorcontrib>Grunder, Lorenz</creatorcontrib><creatorcontrib>Schankin, Christoph</creatorcontrib><creatorcontrib>Scutelnic, Adrian</creatorcontrib><creatorcontrib>Fischer, Urs</creatorcontrib><creatorcontrib>Muri, Raphaela</creatorcontrib><creatorcontrib>Pastore-Wapp, Manuela</creatorcontrib><creatorcontrib>Wiest, Roland</creatorcontrib><creatorcontrib>El-Koussy, Marwan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neuroradiology (Munich)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kellner-Weldon, Frauke</au><au>Jossen, Marina</au><au>Breiding, Philipe S.</au><au>Grunder, Lorenz</au><au>Schankin, Christoph</au><au>Scutelnic, Adrian</au><au>Fischer, Urs</au><au>Muri, Raphaela</au><au>Pastore-Wapp, Manuela</au><au>Wiest, Roland</au><au>El-Koussy, Marwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging</atitle><jtitle>Clinical neuroradiology (Munich)</jtitle><stitle>Clin Neuroradiol</stitle><addtitle>Clin Neuroradiol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>31</volume><issue>3</issue><spage>581</spage><epage>588</epage><pages>581-588</pages><issn>1869-1439</issn><eissn>1869-1447</eissn><abstract>Purpose
Migraine with aura (MwA) in the emergency setting is common and sometimes difficult to distinguish from mimicking conditions. Susceptibility weighted imaging (SWI), a magnet resonance (MR) technique is sensitive to deoxygenated hemoglobin in cerebral veins and depicts these according to their level of oxygenation. Our study aimed at evaluating the frequency of regions of prominent focal veins (PFV) on SWI in the acute phase.
Methods
Between 2011 and 2018 we evaluated symptoms and MR imaging of adult patients with acute MwA attacks (< 5 days after onset of symptoms). Abnormal imaging was visually scored in 12 ROIs on both hemispheres distributed on 3 slices. The score ranged from 0 to 3.
Results
In all, 638 patients (436 female) mean age 37.39 years (18–89 ± 14.13) were included. Susceptibility weighted imaging was abnormal in 18.8% of patients. The inferior and posterior medial temporal lobe and the occipital lobe were most often affected. Susceptibility weighted imaging was more likely abnormal when MR was performed within 24 hours with an average around 5 hours after symptom onset. The side of aura symptoms and hemispheric imaging alteration in patients with abnormal SWI was highly significant (
p
< 0.001).
Conclusion
In the acute episode of MwA, SWI imaging can show a combination of increased deoxygenation. The results may indicate linking PFV to MwA.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33001228</pmid><doi>10.1007/s00062-020-00962-7</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6019-0147</orcidid></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Aged Aged, 80 and over Asymmetry Cerebral Veins Epilepsy Female Hemoglobin Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Middle Aged Migraine Migraine with Aura - diagnostic imaging Neurology Neuroradiology Neurosurgery Original Article Patients Pediatrics Stroke Symmetry Veins & arteries Young Adult |
| title | Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging |
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