Calycosin may Alleviate Ang II-Induced Pro-proliferative Effects on Glomerular Mesangial Cells via Partially Inhibiting Autophagy and ERK Signaling Pathway

Over-expression of angiotensin II (Ang II) is an important reason for the development of chronic kidney disease. Calycosin is the active component of traditional Chinese medicine astragali radix. The present work aims to explore whether calycosin could affect the growth and apoptosis ability of the...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2020/12/01, Vol.43(12), pp.1893-1898
Hauptverfasser:	Ding, Xiaohuan, Lv, Jing, Luan, Jia, Zhang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Apoptosis Autophagy Bcl-2 protein calycosin Cell proliferation extracellular regulated protein kinase Extracellular signal-regulated kinase Flow cytometry glomerular mesangial cell Immunocytochemistry Inhibitor drugs Kidney diseases Mesangial cells Overexpression Phagocytosis proliferation Signal transduction Traditional Chinese medicine
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