Preparation of T‑2 toxin‑containing pH‑sensitive liposome and its antitumor activity

T‑2 toxin is a type A trichothecene mycotoxin. In order to reduce the side effects of T‑2 toxin and increase the tumor targeting ability, a pH‑sensitive liposome of T‑2 toxin (LP‑pHS‑T2) was prepared and characterized in the present study. The cytotoxicity of LP‑pHS‑T2 on A549, Hep‑G2, MKN‑45, K562...

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Veröffentlicht in:	Molecular medicine reports 2020-11, Vol.22 (5), p.4423-4431
Hauptverfasser:	Dong, Yuan, Meng, Guixian, Guo, Jian, Yin, Moli, Xu, Huijing, Li, Yujie, Zhu, Jie, Zhu, Wenhe, Li, Mingguang, Li, Yan, Wang, Huiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Bromine compounds Cancer therapies Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cholesterol Chromatography Controlled release Cytotoxicity Drug development Drug Stability Hemodialysis Hep G2 Cells Humans Hydrogen-Ion Concentration K562 Cells Lecithin Liposomes Mice Molecular weight Morphology Particle Size pH effects Phosphates Phosphatidylcholine Phospholipids Scientific equipment industry Sodium phosphate T-2 Toxin - chemistry T-2 Toxin - pharmacology Transmission electron microscopy Ultrasound
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