Head and neck cancer patient-derived xenograft models – A systematic review
[Display omitted] •This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the procedures used.•PDX recapitulates the histology and molecular aspects of the original HNC tumor.•PDX represents a valuable method in translational...
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| Veröffentlicht in: | Critical reviews in oncology/hematology 2020-11, Vol.155, p.103087-103087, Article 103087 |
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| container_title | Critical reviews in oncology/hematology |
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| creator | Schuch, Lauren F. Silveira, Felipe M. Wagner, Vivian P. Borgato, Gabriell B. Rocha, Guilherme Z. Castilho, Rogerio M. Vargas, Pablo A. Martins, Manoela D. |
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•This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the procedures used.•PDX recapitulates the histology and molecular aspects of the original HNC tumor.•PDX represents a valuable method in translational research for the HNC.
Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes.
An electronic search was undertaken in four databases, including publications having used HNC-PDX. Data were analyzed descriptively.
63 articles were yielded. The nude mouse was one most commonly animal model used (38.8 %), and squamous cell carcinoma accounted for the majority of HNC-PDX (80.6 %). Tumors were mostly implanted in the flank (86.3 %), and the latency period ranged from 30 to 401 days. The successful rate ranged from 17 % to 100 %. Different drugs and pathways were identified.
HNC-PDX appears to significantly recapitulate the morphology of the original HNC and represents a valuable method in translational research for the assessment of the in vivo effect of novel therapies for HNC. |
| doi_str_mv | 10.1016/j.critrevonc.2020.103087 |
| format | Article |
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•This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the procedures used.•PDX recapitulates the histology and molecular aspects of the original HNC tumor.•PDX represents a valuable method in translational research for the HNC.
Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes.
An electronic search was undertaken in four databases, including publications having used HNC-PDX. Data were analyzed descriptively.
63 articles were yielded. The nude mouse was one most commonly animal model used (38.8 %), and squamous cell carcinoma accounted for the majority of HNC-PDX (80.6 %). Tumors were mostly implanted in the flank (86.3 %), and the latency period ranged from 30 to 401 days. The successful rate ranged from 17 % to 100 %. Different drugs and pathways were identified.
HNC-PDX appears to significantly recapitulate the morphology of the original HNC and represents a valuable method in translational research for the assessment of the in vivo effect of novel therapies for HNC.</description><identifier>ISSN: 1040-8428</identifier><identifier>EISSN: 1879-0461</identifier><identifier>DOI: 10.1016/j.critrevonc.2020.103087</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Animal models ; Head and neck neoplasms ; Preclinical drug evaluation ; Translational medical research ; Xenograft model antitumor assays</subject><ispartof>Critical reviews in oncology/hematology, 2020-11, Vol.155, p.103087-103087, Article 103087</ispartof><rights>2020 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-d69b3d491c549da0bfed09e13771f55cd9a7eb1739aad448e0aa5db06327e6103</citedby><cites>FETCH-LOGICAL-c351t-d69b3d491c549da0bfed09e13771f55cd9a7eb1739aad448e0aa5db06327e6103</cites><orcidid>0000-0002-1447-2135</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.critrevonc.2020.103087$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Schuch, Lauren F.</creatorcontrib><creatorcontrib>Silveira, Felipe M.</creatorcontrib><creatorcontrib>Wagner, Vivian P.</creatorcontrib><creatorcontrib>Borgato, Gabriell B.</creatorcontrib><creatorcontrib>Rocha, Guilherme Z.</creatorcontrib><creatorcontrib>Castilho, Rogerio M.</creatorcontrib><creatorcontrib>Vargas, Pablo A.</creatorcontrib><creatorcontrib>Martins, Manoela D.</creatorcontrib><title>Head and neck cancer patient-derived xenograft models – A systematic review</title><title>Critical reviews in oncology/hematology</title><description>[Display omitted]
•This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the procedures used.•PDX recapitulates the histology and molecular aspects of the original HNC tumor.•PDX represents a valuable method in translational research for the HNC.
Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes.
An electronic search was undertaken in four databases, including publications having used HNC-PDX. Data were analyzed descriptively.
63 articles were yielded. The nude mouse was one most commonly animal model used (38.8 %), and squamous cell carcinoma accounted for the majority of HNC-PDX (80.6 %). Tumors were mostly implanted in the flank (86.3 %), and the latency period ranged from 30 to 401 days. The successful rate ranged from 17 % to 100 %. Different drugs and pathways were identified.
HNC-PDX appears to significantly recapitulate the morphology of the original HNC and represents a valuable method in translational research for the assessment of the in vivo effect of novel therapies for HNC.</description><subject>Animal models</subject><subject>Head and neck neoplasms</subject><subject>Preclinical drug evaluation</subject><subject>Translational medical research</subject><subject>Xenograft model antitumor assays</subject><issn>1040-8428</issn><issn>1879-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkE1OwzAQhS0EEqVwBy_ZpIwTJ3aWpQKKVMQG1pZjT5BLfoqdFrrjDtyQk-AqSCxZzWj03tO8jxDKYMaAFVfrmfFu8LjrOzNLIT2cM5DiiEyYFGUCvGDHcQcOieSpPCVnIawBgPNCTMjDErWlurO0Q_NKje4MerrRg8NuSCx6t0NLP7DrX7yuB9r2FptAvz-_6JyGfRiwjVpD4wMO38_JSa2bgBe_c0qeb2-eFstk9Xh3v5ivEpPlLMYWZZVZXjKT89JqqGq0UCLLhGB1nhtbaoEVE1mpteVcImid2wqKLBVYxH5Tcjnmbnz_tsUwqNYFg02jO-y3QaWci5xLmadRKkep8X0IHmu18a7Vfq8YqANBtVZ_BNWBoBoJRuv1aI2ND_W8CiZiMWidRzMo27v_Q34AzXGAYg</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Schuch, Lauren F.</creator><creator>Silveira, Felipe M.</creator><creator>Wagner, Vivian P.</creator><creator>Borgato, Gabriell B.</creator><creator>Rocha, Guilherme Z.</creator><creator>Castilho, Rogerio M.</creator><creator>Vargas, Pablo A.</creator><creator>Martins, Manoela D.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1447-2135</orcidid></search><sort><creationdate>202011</creationdate><title>Head and neck cancer patient-derived xenograft models – A systematic review</title><author>Schuch, Lauren F. ; Silveira, Felipe M. ; Wagner, Vivian P. ; Borgato, Gabriell B. ; Rocha, Guilherme Z. ; Castilho, Rogerio M. ; Vargas, Pablo A. ; Martins, Manoela D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-d69b3d491c549da0bfed09e13771f55cd9a7eb1739aad448e0aa5db06327e6103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal models</topic><topic>Head and neck neoplasms</topic><topic>Preclinical drug evaluation</topic><topic>Translational medical research</topic><topic>Xenograft model antitumor assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schuch, Lauren F.</creatorcontrib><creatorcontrib>Silveira, Felipe M.</creatorcontrib><creatorcontrib>Wagner, Vivian P.</creatorcontrib><creatorcontrib>Borgato, Gabriell B.</creatorcontrib><creatorcontrib>Rocha, Guilherme Z.</creatorcontrib><creatorcontrib>Castilho, Rogerio M.</creatorcontrib><creatorcontrib>Vargas, Pablo A.</creatorcontrib><creatorcontrib>Martins, Manoela D.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in oncology/hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schuch, Lauren F.</au><au>Silveira, Felipe M.</au><au>Wagner, Vivian P.</au><au>Borgato, Gabriell B.</au><au>Rocha, Guilherme Z.</au><au>Castilho, Rogerio M.</au><au>Vargas, Pablo A.</au><au>Martins, Manoela D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Head and neck cancer patient-derived xenograft models – A systematic review</atitle><jtitle>Critical reviews in oncology/hematology</jtitle><date>2020-11</date><risdate>2020</risdate><volume>155</volume><spage>103087</spage><epage>103087</epage><pages>103087-103087</pages><artnum>103087</artnum><issn>1040-8428</issn><eissn>1879-0461</eissn><abstract>[Display omitted]
•This is the first systematic review that summarizes the use of HNC-PDX.•In general, the studies were flawed in terms of detailing the procedures used.•PDX recapitulates the histology and molecular aspects of the original HNC tumor.•PDX represents a valuable method in translational research for the HNC.
Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes.
An electronic search was undertaken in four databases, including publications having used HNC-PDX. Data were analyzed descriptively.
63 articles were yielded. The nude mouse was one most commonly animal model used (38.8 %), and squamous cell carcinoma accounted for the majority of HNC-PDX (80.6 %). Tumors were mostly implanted in the flank (86.3 %), and the latency period ranged from 30 to 401 days. The successful rate ranged from 17 % to 100 %. Different drugs and pathways were identified.
HNC-PDX appears to significantly recapitulate the morphology of the original HNC and represents a valuable method in translational research for the assessment of the in vivo effect of novel therapies for HNC.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.critrevonc.2020.103087</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1447-2135</orcidid></addata></record> |
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| ispartof | Critical reviews in oncology/hematology, 2020-11, Vol.155, p.103087-103087, Article 103087 |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Animal models Head and neck neoplasms Preclinical drug evaluation Translational medical research Xenograft model antitumor assays |
| title | Head and neck cancer patient-derived xenograft models – A systematic review |
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