Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction

Inflammasome-promoted sterile inflammation following cardiac damage is critically implicated in heart dysfunction after myocardial infarction (MI). Glycogen synthase kinase-3 (GSK-3β) is a prominent mediator of the inflammatory response, and high GSK-3 activity is associated with various heart disea...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2020-12, Vol.149, p.82-94
Hauptverfasser:	Wang, Shuhui, Su, Xueling, Xu, Lina, Chang, Cheng, Yao, Yu, Komal, Sumra, Cha, Xuexiang, Zang, Mingxi, Ouyang, Xinshou, Zhang, Lirong, Han, Shengna
Format:	Artikel
Sprache:	eng
Schlagworte:	ASC Cardiac fibroblasts Glycogen synthase kinase 3 Myocardial infarction NLRP3 inflammasome
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