Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study
Background/Objectives Chronic kidney disease (CKD) is a global public health problem, including in China. The aim of this study was to identify the risk factors for the development and progression of subclinical renal disease (SRD) in a Chinese population. We also examined whether the impact of the...
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Veröffentlicht in: | European journal of clinical nutrition 2021-03, Vol.75 (3), p.531-538 |
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creator | Wang, Yang Du, Ming-Fei Gao, Wei-Hua Fu, Bo-Wen Ma, Qiong Yan, Yu Yuan, Yue Chu, Chao Chen, Chen Liao, Yue-Yuan Gao, Ke Wang, Ke-Ke Li, Min Sun, Yue Hu, Jia-Wen Chen, Xin Ma, Qiong Wang, Dan Zhang, Xiao-Yu Li, Chun-Hua Zhou, Hao-Wei Lu, Wan-Hong Yuan, Zu-Yi Chang, John Mu, Jian-Jun |
description | Background/Objectives
Chronic kidney disease (CKD) is a global public health problem, including in China. The aim of this study was to identify the risk factors for the development and progression of subclinical renal disease (SRD) in a Chinese population. We also examined whether the impact of the risk factors on SRD changed over time.
Subjects/Methods
To identify the predictors of SRD, we performed a cross-sectional study of the 2432 subjects in our Hanzhong Adolescent Hypertension Cohort. A subgroup of 202 subjects was further analyzed over a 12-year period from 2005 to 2017 to determine the risk factors for the development and progression of SRD.
Results
In cross-sectional analysis, elevated blood pressure, male gender, diabetes, body mass index, and triglyceride were independently associated with a higher risk of SRD. In longitudinal analysis, an increase in total cholesterol over a 4-year period and an increase in serum triglyceride over a 12-year period were independently associated with progression of albuminuria. Finally, increases in both total cholesterol and serum uric acid over a 4-year follow-up showed an independent association with a modest reduction in estimated glomerular filtration rate (eGFR).
Conclusions
In this study of a Chinese cohort, we show several metabolic abnormalities as independent risk factors for subclinical renal disease in a Chinese cohort. In addition, we demonstrate that the effects of total cholesterol, triglycerides and uric acid on the development and progression of albuminuria or the decline in eGFR vary at different points of follow-up. These findings highlight the importance of early detection of metabolic abnormalities to prevent SRD. |
doi_str_mv | 10.1038/s41430-020-00752-x |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2447547169</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A655716582</galeid><sourcerecordid>A655716582</sourcerecordid><originalsourceid>FETCH-LOGICAL-c511t-8a3a2f97229d93c051c39d2ec4f5ff1a1d10dcb842d00103ea1642157c7d2083</originalsourceid><addsrcrecordid>eNp9kl9rFDEUxYModq1-AR8kIBRfpubvzMS3pbSuUBC07yGb3JlNnUnWZAa6fnqzbrVWFglJIPd3DjeXg9BrSs4p4e37LKjgpCKsbNJIVt09QQsqmrqStSBP0YIoKSpeaifoRc63hJRiw56jE86UElKKBYIvPn_DnbFTTBl3MeE8r-3gg7dmwAlCOZ0ZTQ_YBIf9lPE2xT5Bzj6GD3hlwo9NDD1eujhAthAmvNptIU0Q9gT-Os1u9xI968yQ4dX9fYpuri5vLlbV9eePny6W15WVlE5Va7hhnWoYU05xSyS1XDkGVnSy66ihjhJn161grvyFcDC0FozKxjaOkZafoncH29Li9xnypEdfWhoGEyDOWTMhGikaWquCvv0HvY1zKr_dU0oxxuq2faB6M4D2oYtTMnZvqpe1lMVJtqxQ1RGqhwDJDDFA58vzI_78CF-Wg9Hbo4KzvwQbMMO0yXGYpzLg_BhkB9CmmHOCTm-TH03aaUr0PjP6kBldMqN_ZUbfFdGb-1HM6xHcH8nvkBSAH4BcSqGH9DCr_9j-BMYFyig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2499222688</pqid></control><display><type>article</type><title>Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Wang, Yang ; Du, Ming-Fei ; Gao, Wei-Hua ; Fu, Bo-Wen ; Ma, Qiong ; Yan, Yu ; Yuan, Yue ; Chu, Chao ; Chen, Chen ; Liao, Yue-Yuan ; Gao, Ke ; Wang, Ke-Ke ; Li, Min ; Sun, Yue ; Hu, Jia-Wen ; Chen, Xin ; Ma, Qiong ; Wang, Dan ; Zhang, Xiao-Yu ; Li, Chun-Hua ; Zhou, Hao-Wei ; Lu, Wan-Hong ; Yuan, Zu-Yi ; Chang, John ; Mu, Jian-Jun</creator><creatorcontrib>Wang, Yang ; Du, Ming-Fei ; Gao, Wei-Hua ; Fu, Bo-Wen ; Ma, Qiong ; Yan, Yu ; Yuan, Yue ; Chu, Chao ; Chen, Chen ; Liao, Yue-Yuan ; Gao, Ke ; Wang, Ke-Ke ; Li, Min ; Sun, Yue ; Hu, Jia-Wen ; Chen, Xin ; Ma, Qiong ; Wang, Dan ; Zhang, Xiao-Yu ; Li, Chun-Hua ; Zhou, Hao-Wei ; Lu, Wan-Hong ; Yuan, Zu-Yi ; Chang, John ; Mu, Jian-Jun</creatorcontrib><description>Background/Objectives
Chronic kidney disease (CKD) is a global public health problem, including in China. The aim of this study was to identify the risk factors for the development and progression of subclinical renal disease (SRD) in a Chinese population. We also examined whether the impact of the risk factors on SRD changed over time.
Subjects/Methods
To identify the predictors of SRD, we performed a cross-sectional study of the 2432 subjects in our Hanzhong Adolescent Hypertension Cohort. A subgroup of 202 subjects was further analyzed over a 12-year period from 2005 to 2017 to determine the risk factors for the development and progression of SRD.
Results
In cross-sectional analysis, elevated blood pressure, male gender, diabetes, body mass index, and triglyceride were independently associated with a higher risk of SRD. In longitudinal analysis, an increase in total cholesterol over a 4-year period and an increase in serum triglyceride over a 12-year period were independently associated with progression of albuminuria. Finally, increases in both total cholesterol and serum uric acid over a 4-year follow-up showed an independent association with a modest reduction in estimated glomerular filtration rate (eGFR).
Conclusions
In this study of a Chinese cohort, we show several metabolic abnormalities as independent risk factors for subclinical renal disease in a Chinese cohort. In addition, we demonstrate that the effects of total cholesterol, triglycerides and uric acid on the development and progression of albuminuria or the decline in eGFR vary at different points of follow-up. These findings highlight the importance of early detection of metabolic abnormalities to prevent SRD.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-020-00752-x</identifier><identifier>PMID: 32994554</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/1585 ; Abnormalities ; Adolescent ; Adolescents ; Blood pressure ; Body mass index ; Body size ; China - epidemiology ; Cholesterol ; Chronic kidney failure ; Clinical Nutrition ; Complications and side effects ; Cross-Sectional Studies ; Development and progression ; Diabetes mellitus ; Disease Progression ; Epidemiology ; Epidermal growth factor receptors ; Glomerular Filtration Rate ; Humans ; Hypertension ; Hypertension - epidemiology ; Hypertension - etiology ; Identification methods ; Internal Medicine ; Kidney diseases ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Public Health ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - etiology ; Risk analysis ; Risk Factors ; Subgroups ; Teenagers ; Triglycerides ; Uric Acid</subject><ispartof>European journal of clinical nutrition, 2021-03, Vol.75 (3), p.531-538</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-8a3a2f97229d93c051c39d2ec4f5ff1a1d10dcb842d00103ea1642157c7d2083</citedby><cites>FETCH-LOGICAL-c511t-8a3a2f97229d93c051c39d2ec4f5ff1a1d10dcb842d00103ea1642157c7d2083</cites><orcidid>0000-0002-7717-5031 ; 0000-0002-0335-3528 ; 0000-0002-9362-6680</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32994554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Du, Ming-Fei</creatorcontrib><creatorcontrib>Gao, Wei-Hua</creatorcontrib><creatorcontrib>Fu, Bo-Wen</creatorcontrib><creatorcontrib>Ma, Qiong</creatorcontrib><creatorcontrib>Yan, Yu</creatorcontrib><creatorcontrib>Yuan, Yue</creatorcontrib><creatorcontrib>Chu, Chao</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Liao, Yue-Yuan</creatorcontrib><creatorcontrib>Gao, Ke</creatorcontrib><creatorcontrib>Wang, Ke-Ke</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Sun, Yue</creatorcontrib><creatorcontrib>Hu, Jia-Wen</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Ma, Qiong</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Zhang, Xiao-Yu</creatorcontrib><creatorcontrib>Li, Chun-Hua</creatorcontrib><creatorcontrib>Zhou, Hao-Wei</creatorcontrib><creatorcontrib>Lu, Wan-Hong</creatorcontrib><creatorcontrib>Yuan, Zu-Yi</creatorcontrib><creatorcontrib>Chang, John</creatorcontrib><creatorcontrib>Mu, Jian-Jun</creatorcontrib><title>Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives
Chronic kidney disease (CKD) is a global public health problem, including in China. The aim of this study was to identify the risk factors for the development and progression of subclinical renal disease (SRD) in a Chinese population. We also examined whether the impact of the risk factors on SRD changed over time.
Subjects/Methods
To identify the predictors of SRD, we performed a cross-sectional study of the 2432 subjects in our Hanzhong Adolescent Hypertension Cohort. A subgroup of 202 subjects was further analyzed over a 12-year period from 2005 to 2017 to determine the risk factors for the development and progression of SRD.
Results
In cross-sectional analysis, elevated blood pressure, male gender, diabetes, body mass index, and triglyceride were independently associated with a higher risk of SRD. In longitudinal analysis, an increase in total cholesterol over a 4-year period and an increase in serum triglyceride over a 12-year period were independently associated with progression of albuminuria. Finally, increases in both total cholesterol and serum uric acid over a 4-year follow-up showed an independent association with a modest reduction in estimated glomerular filtration rate (eGFR).
Conclusions
In this study of a Chinese cohort, we show several metabolic abnormalities as independent risk factors for subclinical renal disease in a Chinese cohort. In addition, we demonstrate that the effects of total cholesterol, triglycerides and uric acid on the development and progression of albuminuria or the decline in eGFR vary at different points of follow-up. These findings highlight the importance of early detection of metabolic abnormalities to prevent SRD.</description><subject>692/499</subject><subject>692/699/1585</subject><subject>Abnormalities</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Body size</subject><subject>China - epidemiology</subject><subject>Cholesterol</subject><subject>Chronic kidney failure</subject><subject>Clinical Nutrition</subject><subject>Complications and side effects</subject><subject>Cross-Sectional Studies</subject><subject>Development and progression</subject><subject>Diabetes mellitus</subject><subject>Disease Progression</subject><subject>Epidemiology</subject><subject>Epidermal growth factor receptors</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - etiology</subject><subject>Identification methods</subject><subject>Internal Medicine</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Public Health</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - etiology</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Subgroups</subject><subject>Teenagers</subject><subject>Triglycerides</subject><subject>Uric Acid</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kl9rFDEUxYModq1-AR8kIBRfpubvzMS3pbSuUBC07yGb3JlNnUnWZAa6fnqzbrVWFglJIPd3DjeXg9BrSs4p4e37LKjgpCKsbNJIVt09QQsqmrqStSBP0YIoKSpeaifoRc63hJRiw56jE86UElKKBYIvPn_DnbFTTBl3MeE8r-3gg7dmwAlCOZ0ZTQ_YBIf9lPE2xT5Bzj6GD3hlwo9NDD1eujhAthAmvNptIU0Q9gT-Os1u9xI968yQ4dX9fYpuri5vLlbV9eePny6W15WVlE5Va7hhnWoYU05xSyS1XDkGVnSy66ihjhJn161grvyFcDC0FozKxjaOkZafoncH29Li9xnypEdfWhoGEyDOWTMhGikaWquCvv0HvY1zKr_dU0oxxuq2faB6M4D2oYtTMnZvqpe1lMVJtqxQ1RGqhwDJDDFA58vzI_78CF-Wg9Hbo4KzvwQbMMO0yXGYpzLg_BhkB9CmmHOCTm-TH03aaUr0PjP6kBldMqN_ZUbfFdGb-1HM6xHcH8nvkBSAH4BcSqGH9DCr_9j-BMYFyig</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Wang, 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factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study</title><author>Wang, Yang ; Du, Ming-Fei ; Gao, Wei-Hua ; Fu, Bo-Wen ; Ma, Qiong ; Yan, Yu ; Yuan, Yue ; Chu, Chao ; Chen, Chen ; Liao, Yue-Yuan ; Gao, Ke ; Wang, Ke-Ke ; Li, Min ; Sun, Yue ; Hu, Jia-Wen ; Chen, Xin ; Ma, Qiong ; Wang, Dan ; Zhang, Xiao-Yu ; Li, Chun-Hua ; Zhou, Hao-Wei ; Lu, Wan-Hong ; Yuan, Zu-Yi ; Chang, John ; Mu, Jian-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-8a3a2f97229d93c051c39d2ec4f5ff1a1d10dcb842d00103ea1642157c7d2083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/499</topic><topic>692/699/1585</topic><topic>Abnormalities</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Body size</topic><topic>China - epidemiology</topic><topic>Cholesterol</topic><topic>Chronic kidney failure</topic><topic>Clinical Nutrition</topic><topic>Complications and side effects</topic><topic>Cross-Sectional Studies</topic><topic>Development and progression</topic><topic>Diabetes mellitus</topic><topic>Disease Progression</topic><topic>Epidemiology</topic><topic>Epidermal growth factor receptors</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - etiology</topic><topic>Identification methods</topic><topic>Internal Medicine</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Public Health</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - etiology</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Subgroups</topic><topic>Teenagers</topic><topic>Triglycerides</topic><topic>Uric Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yang</creatorcontrib><creatorcontrib>Du, Ming-Fei</creatorcontrib><creatorcontrib>Gao, Wei-Hua</creatorcontrib><creatorcontrib>Fu, Bo-Wen</creatorcontrib><creatorcontrib>Ma, Qiong</creatorcontrib><creatorcontrib>Yan, Yu</creatorcontrib><creatorcontrib>Yuan, Yue</creatorcontrib><creatorcontrib>Chu, Chao</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Liao, Yue-Yuan</creatorcontrib><creatorcontrib>Gao, Ke</creatorcontrib><creatorcontrib>Wang, Ke-Ke</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Sun, Yue</creatorcontrib><creatorcontrib>Hu, Jia-Wen</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Ma, Qiong</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Zhang, 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Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yang</au><au>Du, Ming-Fei</au><au>Gao, Wei-Hua</au><au>Fu, Bo-Wen</au><au>Ma, Qiong</au><au>Yan, Yu</au><au>Yuan, Yue</au><au>Chu, Chao</au><au>Chen, Chen</au><au>Liao, Yue-Yuan</au><au>Gao, Ke</au><au>Wang, Ke-Ke</au><au>Li, Min</au><au>Sun, Yue</au><au>Hu, Jia-Wen</au><au>Chen, Xin</au><au>Ma, Qiong</au><au>Wang, Dan</au><au>Zhang, Xiao-Yu</au><au>Li, Chun-Hua</au><au>Zhou, Hao-Wei</au><au>Lu, Wan-Hong</au><au>Yuan, Zu-Yi</au><au>Chang, John</au><au>Mu, Jian-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>75</volume><issue>3</issue><spage>531</spage><epage>538</epage><pages>531-538</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives
Chronic kidney disease (CKD) is a global public health problem, including in China. The aim of this study was to identify the risk factors for the development and progression of subclinical renal disease (SRD) in a Chinese population. We also examined whether the impact of the risk factors on SRD changed over time.
Subjects/Methods
To identify the predictors of SRD, we performed a cross-sectional study of the 2432 subjects in our Hanzhong Adolescent Hypertension Cohort. A subgroup of 202 subjects was further analyzed over a 12-year period from 2005 to 2017 to determine the risk factors for the development and progression of SRD.
Results
In cross-sectional analysis, elevated blood pressure, male gender, diabetes, body mass index, and triglyceride were independently associated with a higher risk of SRD. In longitudinal analysis, an increase in total cholesterol over a 4-year period and an increase in serum triglyceride over a 12-year period were independently associated with progression of albuminuria. Finally, increases in both total cholesterol and serum uric acid over a 4-year follow-up showed an independent association with a modest reduction in estimated glomerular filtration rate (eGFR).
Conclusions
In this study of a Chinese cohort, we show several metabolic abnormalities as independent risk factors for subclinical renal disease in a Chinese cohort. In addition, we demonstrate that the effects of total cholesterol, triglycerides and uric acid on the development and progression of albuminuria or the decline in eGFR vary at different points of follow-up. These findings highlight the importance of early detection of metabolic abnormalities to prevent SRD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32994554</pmid><doi>10.1038/s41430-020-00752-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7717-5031</orcidid><orcidid>https://orcid.org/0000-0002-0335-3528</orcidid><orcidid>https://orcid.org/0000-0002-9362-6680</orcidid></addata></record> |
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ispartof | European journal of clinical nutrition, 2021-03, Vol.75 (3), p.531-538 |
issn | 0954-3007 1476-5640 |
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source | MEDLINE; Alma/SFX Local Collection |
subjects | 692/499 692/699/1585 Abnormalities Adolescent Adolescents Blood pressure Body mass index Body size China - epidemiology Cholesterol Chronic kidney failure Clinical Nutrition Complications and side effects Cross-Sectional Studies Development and progression Diabetes mellitus Disease Progression Epidemiology Epidermal growth factor receptors Glomerular Filtration Rate Humans Hypertension Hypertension - epidemiology Hypertension - etiology Identification methods Internal Medicine Kidney diseases Male Medicine Medicine & Public Health Metabolic Diseases Metabolism Public Health Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - etiology Risk analysis Risk Factors Subgroups Teenagers Triglycerides Uric Acid |
title | Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A37%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20factors%20for%20subclinical%20renal%20damage%20and%20its%20progression:%20Hanzhong%20Adolescent%20Hypertension%20Study&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Wang,%20Yang&rft.date=2021-03-01&rft.volume=75&rft.issue=3&rft.spage=531&rft.epage=538&rft.pages=531-538&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/s41430-020-00752-x&rft_dat=%3Cgale_proqu%3EA655716582%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2499222688&rft_id=info:pmid/32994554&rft_galeid=A655716582&rfr_iscdi=true |