Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients
Introduction The objective of this study was to evaluate the impact of operative timing on outcomes of acute appendicitis. Methods This study examined adult patients who had presented to the hospital with acute appendicitis and had undergone appendectomy from December 2017 to February 2019. Time del...
Gespeichert in:
| Veröffentlicht in: | Asian journal of endoscopic surgery 2021-07, Vol.14 (3), p.361-367 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 367 |
|---|---|
| container_issue | 3 |
| container_start_page | 361 |
| container_title | Asian journal of endoscopic surgery |
| container_volume | 14 |
| creator | Jiang, Li Liu, Zhonghui Tong, Xiaojun Deng, Yang Liu, Jianwen Yang, Xuefei Chan, Fion S.Y. Fan, Joe K.M. |
| description | Introduction
The objective of this study was to evaluate the impact of operative timing on outcomes of acute appendicitis.
Methods
This study examined adult patients who had presented to the hospital with acute appendicitis and had undergone appendectomy from December 2017 to February 2019. Time delay and outcomes of perforated and non‐perforated appendicitis were compared. Patients were classified into five groups based on the period from symptom onset to operation: group 1, |
| doi_str_mv | 10.1111/ases.12870 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2447545892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2447545892</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3580-9f7e3786c5649ab980c5e9ae95fe263218d72384c142c511d6a0e86576de661d3</originalsourceid><addsrcrecordid>eNp9kc1u2zAQhIWiAeomufQJCPQSFHBCUuKPToHhuD-AgRySnAmWWtU0LFHhUgn0FH3l0nbgQw_Zy-zhm8Eupii-MHrN8txYBLxmXCv6oZgxJfRc1Ix-PO2Ufyo-I24plYpV5az4excASdoASb4D0sbQEZy6IWUNPUIiKRAc4x-IE7FtCy4d6DAmF7psDS0ZbPLQJySvPm2IdWMCYocB-sY7nzzekgUZYsAhm_0LEBc2ISaCaWymvZ8Lccq4KM5au0O4fNPz4un76nH5c76-__FruVjPXSk0ndetglJp6YSsavu71tQJqC3UogUuS850o3ipK8cq7gRjjbQUtBRKNiAla8rz4uqYmw97HgGT6Tw62O1sD2FEw6tKiUrommf063_oNoyxz9cZLirFyj2YqW9HyuVPMUJrhug7GyfDqNl3Y_bdmEM3GWZH-NXvYHqHNIuH1cPR8w-1-JJ1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2547137545</pqid></control><display><type>article</type><title>Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Jiang, Li ; Liu, Zhonghui ; Tong, Xiaojun ; Deng, Yang ; Liu, Jianwen ; Yang, Xuefei ; Chan, Fion S.Y. ; Fan, Joe K.M.</creator><creatorcontrib>Jiang, Li ; Liu, Zhonghui ; Tong, Xiaojun ; Deng, Yang ; Liu, Jianwen ; Yang, Xuefei ; Chan, Fion S.Y. ; Fan, Joe K.M.</creatorcontrib><description><![CDATA[Introduction
The objective of this study was to evaluate the impact of operative timing on outcomes of acute appendicitis.
Methods
This study examined adult patients who had presented to the hospital with acute appendicitis and had undergone appendectomy from December 2017 to February 2019. Time delay and outcomes of perforated and non‐perforated appendicitis were compared. Patients were classified into five groups based on the period from symptom onset to operation: group 1, <24 hours; group 2, ≥24 and <48 hours; group 3, ≥48 and <72 hours; group 4, ≥72 and <96 hours; and group 5, ≥96 hours. The five groups were compared, with risk of perforation assessed in particular.
Results
A total of 255 patients were included in the analysis. Symptom duration, operative time, and length of postoperative hospital stay (P < .001) were significantly longer in the perforated group (n = 49) than in the non‐perforated group (n = 206). The perforated group also had a higher conversion rate to open procedures (P = .002) and a higher rate of wound infection (P = .034). Group 1 had 53 patients, group 2 had 95 patients, group 3 had 57 patients, group 4 had 32 patients, and group 5 had 18 patients. The incidence of appendiceal perforation and median operative time progressively increased along with symptom duration in the five groups. In multivariate analyses, independent risk factors for appendiceal perforation were male gender (odds ratio = 2.33, 95% confidence interval [CI]: 1.07‐5.08) and symptom duration ≥48 hours (relative to ≥24 and <48 hours) (odds ratio = 4.64, 95%CI: 1.76‐12.27). Patients with symptom duration ≥72 hours had a significantly longer operative time than those with symptom duration ≥48 and <72 hours (β = 21.38, 95%CI: 5.66‐37.11, P = .008).
Conclusion
The risk of perforation increased significantly 48 hours after the onset of appendicitis. Symptoms duration ≥72 hours was associated with a longer operative time.]]></description><identifier>ISSN: 1758-5902</identifier><identifier>EISSN: 1758-5910</identifier><identifier>DOI: 10.1111/ases.12870</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>acute appendicitis ; Appendicitis ; Cohort analysis ; operative timing ; perforation ; Surgical outcomes</subject><ispartof>Asian journal of endoscopic surgery, 2021-07, Vol.14 (3), p.361-367</ispartof><rights>2020 Asia Endosurgery Task Force and Japan Society of Endoscopic Surgery and John Wiley & Sons Australia, Ltd</rights><rights>2021 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3580-9f7e3786c5649ab980c5e9ae95fe263218d72384c142c511d6a0e86576de661d3</citedby><cites>FETCH-LOGICAL-c3580-9f7e3786c5649ab980c5e9ae95fe263218d72384c142c511d6a0e86576de661d3</cites><orcidid>0000-0001-6604-2295 ; 0000-0002-9022-0685</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fases.12870$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fases.12870$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Jiang, Li</creatorcontrib><creatorcontrib>Liu, Zhonghui</creatorcontrib><creatorcontrib>Tong, Xiaojun</creatorcontrib><creatorcontrib>Deng, Yang</creatorcontrib><creatorcontrib>Liu, Jianwen</creatorcontrib><creatorcontrib>Yang, Xuefei</creatorcontrib><creatorcontrib>Chan, Fion S.Y.</creatorcontrib><creatorcontrib>Fan, Joe K.M.</creatorcontrib><title>Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients</title><title>Asian journal of endoscopic surgery</title><description><![CDATA[Introduction
The objective of this study was to evaluate the impact of operative timing on outcomes of acute appendicitis.
Methods
This study examined adult patients who had presented to the hospital with acute appendicitis and had undergone appendectomy from December 2017 to February 2019. Time delay and outcomes of perforated and non‐perforated appendicitis were compared. Patients were classified into five groups based on the period from symptom onset to operation: group 1, <24 hours; group 2, ≥24 and <48 hours; group 3, ≥48 and <72 hours; group 4, ≥72 and <96 hours; and group 5, ≥96 hours. The five groups were compared, with risk of perforation assessed in particular.
Results
A total of 255 patients were included in the analysis. Symptom duration, operative time, and length of postoperative hospital stay (P < .001) were significantly longer in the perforated group (n = 49) than in the non‐perforated group (n = 206). The perforated group also had a higher conversion rate to open procedures (P = .002) and a higher rate of wound infection (P = .034). Group 1 had 53 patients, group 2 had 95 patients, group 3 had 57 patients, group 4 had 32 patients, and group 5 had 18 patients. The incidence of appendiceal perforation and median operative time progressively increased along with symptom duration in the five groups. In multivariate analyses, independent risk factors for appendiceal perforation were male gender (odds ratio = 2.33, 95% confidence interval [CI]: 1.07‐5.08) and symptom duration ≥48 hours (relative to ≥24 and <48 hours) (odds ratio = 4.64, 95%CI: 1.76‐12.27). Patients with symptom duration ≥72 hours had a significantly longer operative time than those with symptom duration ≥48 and <72 hours (β = 21.38, 95%CI: 5.66‐37.11, P = .008).
Conclusion
The risk of perforation increased significantly 48 hours after the onset of appendicitis. Symptoms duration ≥72 hours was associated with a longer operative time.]]></description><subject>acute appendicitis</subject><subject>Appendicitis</subject><subject>Cohort analysis</subject><subject>operative timing</subject><subject>perforation</subject><subject>Surgical outcomes</subject><issn>1758-5902</issn><issn>1758-5910</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u2zAQhIWiAeomufQJCPQSFHBCUuKPToHhuD-AgRySnAmWWtU0LFHhUgn0FH3l0nbgQw_Zy-zhm8Eupii-MHrN8txYBLxmXCv6oZgxJfRc1Ix-PO2Ufyo-I24plYpV5az4excASdoASb4D0sbQEZy6IWUNPUIiKRAc4x-IE7FtCy4d6DAmF7psDS0ZbPLQJySvPm2IdWMCYocB-sY7nzzekgUZYsAhm_0LEBc2ISaCaWymvZ8Lccq4KM5au0O4fNPz4un76nH5c76-__FruVjPXSk0ndetglJp6YSsavu71tQJqC3UogUuS850o3ipK8cq7gRjjbQUtBRKNiAla8rz4uqYmw97HgGT6Tw62O1sD2FEw6tKiUrommf063_oNoyxz9cZLirFyj2YqW9HyuVPMUJrhug7GyfDqNl3Y_bdmEM3GWZH-NXvYHqHNIuH1cPR8w-1-JJ1</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Jiang, Li</creator><creator>Liu, Zhonghui</creator><creator>Tong, Xiaojun</creator><creator>Deng, Yang</creator><creator>Liu, Jianwen</creator><creator>Yang, Xuefei</creator><creator>Chan, Fion S.Y.</creator><creator>Fan, Joe K.M.</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6604-2295</orcidid><orcidid>https://orcid.org/0000-0002-9022-0685</orcidid></search><sort><creationdate>202107</creationdate><title>Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients</title><author>Jiang, Li ; Liu, Zhonghui ; Tong, Xiaojun ; Deng, Yang ; Liu, Jianwen ; Yang, Xuefei ; Chan, Fion S.Y. ; Fan, Joe K.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3580-9f7e3786c5649ab980c5e9ae95fe263218d72384c142c511d6a0e86576de661d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>acute appendicitis</topic><topic>Appendicitis</topic><topic>Cohort analysis</topic><topic>operative timing</topic><topic>perforation</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Li</creatorcontrib><creatorcontrib>Liu, Zhonghui</creatorcontrib><creatorcontrib>Tong, Xiaojun</creatorcontrib><creatorcontrib>Deng, Yang</creatorcontrib><creatorcontrib>Liu, Jianwen</creatorcontrib><creatorcontrib>Yang, Xuefei</creatorcontrib><creatorcontrib>Chan, Fion S.Y.</creatorcontrib><creatorcontrib>Fan, Joe K.M.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Asian journal of endoscopic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Li</au><au>Liu, Zhonghui</au><au>Tong, Xiaojun</au><au>Deng, Yang</au><au>Liu, Jianwen</au><au>Yang, Xuefei</au><au>Chan, Fion S.Y.</au><au>Fan, Joe K.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients</atitle><jtitle>Asian journal of endoscopic surgery</jtitle><date>2021-07</date><risdate>2021</risdate><volume>14</volume><issue>3</issue><spage>361</spage><epage>367</epage><pages>361-367</pages><issn>1758-5902</issn><eissn>1758-5910</eissn><abstract><![CDATA[Introduction
The objective of this study was to evaluate the impact of operative timing on outcomes of acute appendicitis.
Methods
This study examined adult patients who had presented to the hospital with acute appendicitis and had undergone appendectomy from December 2017 to February 2019. Time delay and outcomes of perforated and non‐perforated appendicitis were compared. Patients were classified into five groups based on the period from symptom onset to operation: group 1, <24 hours; group 2, ≥24 and <48 hours; group 3, ≥48 and <72 hours; group 4, ≥72 and <96 hours; and group 5, ≥96 hours. The five groups were compared, with risk of perforation assessed in particular.
Results
A total of 255 patients were included in the analysis. Symptom duration, operative time, and length of postoperative hospital stay (P < .001) were significantly longer in the perforated group (n = 49) than in the non‐perforated group (n = 206). The perforated group also had a higher conversion rate to open procedures (P = .002) and a higher rate of wound infection (P = .034). Group 1 had 53 patients, group 2 had 95 patients, group 3 had 57 patients, group 4 had 32 patients, and group 5 had 18 patients. The incidence of appendiceal perforation and median operative time progressively increased along with symptom duration in the five groups. In multivariate analyses, independent risk factors for appendiceal perforation were male gender (odds ratio = 2.33, 95% confidence interval [CI]: 1.07‐5.08) and symptom duration ≥48 hours (relative to ≥24 and <48 hours) (odds ratio = 4.64, 95%CI: 1.76‐12.27). Patients with symptom duration ≥72 hours had a significantly longer operative time than those with symptom duration ≥48 and <72 hours (β = 21.38, 95%CI: 5.66‐37.11, P = .008).
Conclusion
The risk of perforation increased significantly 48 hours after the onset of appendicitis. Symptoms duration ≥72 hours was associated with a longer operative time.]]></abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><doi>10.1111/ases.12870</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6604-2295</orcidid><orcidid>https://orcid.org/0000-0002-9022-0685</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1758-5902 |
| ispartof | Asian journal of endoscopic surgery, 2021-07, Vol.14 (3), p.361-367 |
| issn | 1758-5902 1758-5910 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2447545892 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | acute appendicitis Appendicitis Cohort analysis operative timing perforation Surgical outcomes |
| title | Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T12%3A51%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20the%20time%20from%20symptom%20onset%20to%20surgery%20affect%20the%20outcomes%20of%20patients%20with%20acute%20appendicitis?%20A%20prospective%20cohort%20study%20of%20255%20patients&rft.jtitle=Asian%20journal%20of%20endoscopic%20surgery&rft.au=Jiang,%20Li&rft.date=2021-07&rft.volume=14&rft.issue=3&rft.spage=361&rft.epage=367&rft.pages=361-367&rft.issn=1758-5902&rft.eissn=1758-5910&rft_id=info:doi/10.1111/ases.12870&rft_dat=%3Cproquest_cross%3E2447545892%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2547137545&rft_id=info:pmid/&rfr_iscdi=true |