L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5-and Adjacent L4-Dorsal Root Ganglion Neurons in Rats In Vivo

Peripheral neuropathic pain (PNP) is a major health problem for which effective drug treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical studies using animal models of PNP including the L5-spinal nerve axotomy (L5-SNA) model, suggest that it is partly caused...

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Veröffentlicht in:	Journal of neurotrauma 2021-02, Vol.38 (3), p.330-341
Hauptverfasser:	Djouhri, Laiche, Zeidan, Asad, Alzoghaibi, Mohammad, Al Otaibi, Mohammad F., Abd El-Aleem, Seham A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Axotomy Behavior Blood pressure Central nervous system Clinical Neurology Critical Care Medicine Dorsal root ganglia Excitability Experiments Fibers General & Internal Medicine Hyperpolarization Hypersensitivity Inflammation Life Sciences & Biomedicine Neurodegeneration Neurons Neurosciences Neurosciences & Neurology Neurotransmitter release Nociceptors Pain Pain perception Peripheral neuropathy Science & Technology Sensory neurons Spinal nerves Surgery Trophic factors
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